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21 articles for “solvent evaporation technique”
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Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design
Abstract: This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 25–31 Read article
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Formulation and Evaluation of Microballoons of Ramipril
Abstract: The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 13–30 Read article
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Fabrication and Assessment of Gallic Acid as Novel Drug Carrier
Abstract: Objective: The purpose of the current investigation is to develop and evaluate the polymer-based microspheres to overcome the issues of frequent dosing and high first pass metabolism. Materials and Methods: Gallic acid loaded microsphere were prepared by solvent evaporation technique and the microspheres were evaluated for drug entrapment efficiency, drug loading efficacy, particle size, In-vitro drug release, surface morphology and FTIR spectroscopy studies. Results: The percentage yield, drug entrapment and …
Published in Trends in Drug Delivery · Vol. 6, Issue 2, 2019 · pp. 5–10 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Formulation and Evaluation of Microencapsulated Levofloxacin Gel
Abstract: To treat various buccal infectious diseases, a sustained release microencapsulated levofloxacin gel was formulated. Levofloxacin microspheres were being prepared following o/w emulsion solvent evaporation technique by varying concentrations of ethyl acetate, ethyl cellulose and tween 80. Depending on their flow properties almost all the microspheres were found to be excellent. The drug-excipient compatibility study carried out using Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) resulted that the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 39–47 Read article
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Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement
Abstract: This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 39–48 Read article
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Microsphere: A Novel Drug Delivery System Approach
Abstract: Microspheres are the multiarticulate novel drug delivery dosage form, it contains the particle size range from 1 to 50 µ and characteristically spherical in shape with free flow property. It is widely known as “Microparticles”. Microspheres are prepared by covering the drug particles with polymeric solution (obtained in natural, semisynthetic or synthetic form) to achieve controlled release of drug, which produces prolonged action with reduced toxicity at the specified site …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 24–30 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Solubility Enhancement Technique for Verapamil by Solid Dispersion Method
Abstract: By creating a solid dispersion, this study aimed to address the limitations of the traditional solid dosage form of verapamil, including its low bioavailability and restricted clinical efficacy. In order to alter the drug's release and improve its solubility, verapamil solid dispersion was created using the Solvent Evaporation Method and Fusion Method. The physical state of the solid dispersed verapamil was determined using saturation solubility testing and dissolution studies. Verapamil …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 94–99 Read article
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Manganese Mercury Thiocyanate Doped Zirconium Silicate Crystal Structure for Photo-Electronic, Electro-Optic and Sensor Applications
Abstract: Manganese mercury thiocyanate is a well-known organometallic crystal prized for its nonlinear optical properties. The high second harmonic efficiency of nearly 18 times that of urea and the wide optical transmittance window (373–2250 nm) of MMTC indicate that this material is an excellent candidate for photonics device fabrication. The metal thiocyanates and their Lewis-base adducts are one of the interesting themes of structural chemistry. For MMTC is a very flexible …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 2, 2026 Read article
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Microencapsulation Technology and It’s Application in Dairy Industry: A Review
Abstract: Microencapsulation of bioactive compound or nutrient is one of the important applications in dairy and food industry. Microencapsulation is an attractive technique to enhance the stability of bioactive compounds with controlled release. This article provides an overview of various encapsulation techniques such as spray drying, fluidized-bed drying, solvent evaporation, coacervation and extrusion method, and different encapsulated bioactive compounds or nutrient which have been used for the fortification of dairy products …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 10, Issue 3, 2021 · pp. 1–7 Read article
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The Effect of L-Valine on the Growth and Characterization of Lithium Sulphate Monohydrate Single Crystals
Abstract: Pure and amino acid doped good quality single crystals of Lithium Sulphate Monohydrate (LSM) were grown by slow evaporation solution growth technique at room temperature using water as solvent. The effect of amino acid (L-valine) dopant on the growth and characterization of LSM single crystal was investigated. Single-crystal X-ray diffractometer was utilized to find the unit cell parameters for pure and L-valine doped LSM crystals. The powder X-ray diffraction pattern …
Published in Research & Reviews : Journal of Physics · Vol. 8, Issue 1, 2019 · pp. 92–103 Read article
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Inorganic Substances are Studied Using the Chromatographic Technique
Abstract: Inorganic analysis's use of separations is described, and the benefits of various chromatographic procedures are emphasized. Ion-exchange chromatography, solvent evaporation, columns extraction chromatography, gas chromatography of volatile metal chelates, column chromatography using chelating resins, and column chromatography using non-ionic sportive resins are some common separation techniques. Specific examples are shown to demonstrate how each of these techniques is used in analysis. A comparison of the state-ofthe-art in organic and inorganic …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 13, Issue 2, 2022 · pp. 29–33 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents
Abstract: The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 406–419 Read article
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Innovative Approaches in Excipient Co-Processing: A Comprehensive Review
Abstract: Co-processing of existing excipients is an innovative strategy in pharmaceutical formulation that offers a cost-effective, efficient alternative to the development of entirely new excipients. This process involves combining two or more well-established excipients to create new material with enhanced properties, thereby improving the functionality, performance, and manufacturability of pharmaceutical products. By leveraging the unique characteristics of each excipient, co-processing can significantly enhance attributes, such as flowability, compressibility, solubility, stability, and …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 34–51 Read article
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A Review on Novel Emulsification Technique: A Nanoemulsion
Abstract: Kinetically stable and isotropic system of submicron size range is the nanoemulsion. In this system two immiscible liquids are mixed together to form a single-phase system with the identical concentration and ratio of surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20- 200 nm. Some literature suggest this range below 100 nm with shows narrow size distribution. In this review, major focus is given on the …
Published in Trends in Drug Delivery · Vol. 3, Issue 2, 2016 · pp. 25–34 Read article
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Structure and Crystal Growth of Urea Doped P- Block Element
Abstract: Nonlinear optical (NLO) materials exhibiting second harmonic generation have attracted considerable attention over the past few decades because of their technological significance in areas such as optical communication, signal processing, and instrumentation. Urea, being an important NLO material, presents challenges in crystal growth and handling due to its highly hygroscopic nature. Various derivatives of urea have been investigated for NLO applications, and some have shown promising potential in this field. …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 2, 2026 · pp. 08–13 Read article
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Long Acting Depot Formulation: History, Mechanism, its Manufacturing and Market Review
Abstract: Patient compliance is a very important factor in the treatment of any disease. Specially intreatment of chronic diseases such as cancer, arthritis, psychosis patient need to take medicinefor longer time. In such cases long-acting depot injection became excellent option for treatment.This drug delivery involves drug release over a period of several weeks and months. These depotformulations can be prepared by using biodegradable polymer Poly (lactide-co-glycolide)PLGA. Various methods are widely used …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 36–46 Read article
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Techniques for Characterization of Anticancer Drug Loaded Polymeric Nanoparticles: A Review
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Polymeric nanoparticles have been used for targeted drug delivery against different diseases during last decades. Particularly in cancer, targeted polymeric nanoparticles can be used to deliver anticancer drugs to cancer cells with reduced cytotoxicity and greater efficacy. Various natural polymers like chitosan, albumin, gelatin and synthetic such as Polylactides (PLA), Poly (Lactide co-Glycolides) (PLGA) have been researched as carrier of anticancer drugs. …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 5, Issue 2, 2015 · pp. 32–43 Read article