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Research & Reviews: A Journal of Drug Formulation, Development and Production

Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design

  1. Sake Vaishnavi S.
  2. Rajendra Surawase
  3. Narote sudam R
  4. Shruti Raundal
  5. Borse Sudarshan
  6. Mayur Sonawane

Abstract

This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The Box-Behnken design was applied to develop the ibuprofen tablet formulation, taking into account poloxamer 407, SSG, and MMC as independent factors, and drug release and compression index as dependent variables.

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