solvent evaporation technique

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• Published Subscription 29 Aug 2022

  Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design

  By Sake Vaishnavi S., Rajendra Surawase, Narote sudam R, Shruti Raundal, Borse Sudarshan, Mayur Sonawane

  Abstract: This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The …

  Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 25–31 Read article →