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59 articles for “solid dispersions”
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Enhancement of Aqueous Solubility of Etoposide Using Solid Dispersion Technique
Abstract: Objective: The objective of present research work was to enhance the aqueous solubility of Etoposide using solid dispersion technique. Methods: Formulation of solid dispersion by using different polymers and their different ratio with the used of solid dispersion technique. Solid dispersion formulation F-1 to F-9 were prepared by using different type and different concentration of polymers like PEG-6000, PEG-4000 poloxomer 407 and ethanol respectively. Results: The solid dispersion formulation were …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 1, 2019 · pp. 29–37 Read article
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Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility Enhancement
Abstract: This study was mainly designed to solve the drawbacks of conventional verapamil solid dosage form, low bioavailability and limited clinical efficacy, by preparing solid dispersion. Verapamil solid dispersion was developed by kneading method, melt solvent method and co-precipitation method to modify the release and enhance solubility of the drug. The physical state of the dispersed verapamil in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 39–54 Read article
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Solubility Enhancement Technique for Verapamil by Solid Dispersion Method
Abstract: By creating a solid dispersion, this study aimed to address the limitations of the traditional solid dosage form of verapamil, including its low bioavailability and restricted clinical efficacy. In order to alter the drug's release and improve its solubility, verapamil solid dispersion was created using the Solvent Evaporation Method and Fusion Method. The physical state of the solid dispersed verapamil was determined using saturation solubility testing and dissolution studies. Verapamil …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 94–99 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 01–12 Read article
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Preparation and Characterization of Solid Dispersion of Tenoxicam
Abstract: The aim of the present study was to prepare solid dispersions of a poorly water-soluble drug Tenoxicam in Polyvinylpyrrolidone (PVP), prepared by spray-drying techniques. The physicochemical properties of the solid dispersion and drug-polymer interactions were characterized by DSC, FT-IR, XRD and SEM. Tenoxicam was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:3. Dissolution profile of the prepared solid dispersion was compared with …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 23–29 Read article
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Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate
Abstract: In present study an attempt was made to enhance the solubility of beclomethasone dipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasone dipropionate to improve the patient compliance. Beclomethasone dipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasone dipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 30–41 Read article
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Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design
Abstract: This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 25–31 Read article
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Preparation and Characterization of Microwave-assisted Candesartan Cilexetil Solid Dispersions
Abstract: The aim of the present study was to enhance the solubility & dissolution rate of a poorly soluble, BCS class II drug candesartan cilexetil (CC), using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000 & hydroxypropyl methylcellulose (HPMC) E5. Solid dispersions were prepared by melting, solvent evaporation & microwave method. The dispersions were evaluated for various in vitro parameters such as solubility study, dissolution study, fourier transform infrared spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 3, 2013 · pp. 9–19 Read article
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A Factorial Study on the Evaluation of the Effects of Starch, PVP and PEG 6000 on the Dissolution Rate of Pioglitazone Solid Dispersions
Abstract: Pioglitazone, a relatively new oral anti-diabetic drug belongs to BCS class II with low solubility and high permeability, and as such exhibits low and variable oral bioavailability. It needs enhancement in solubility and dissolution rate for improving its oral bioavailability and consequent reduction in dose. The specific objectives of the study are 1. To evaluate starch as a carrier for enhancing the dissolution rate of pioglitazone, a BCS class II …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 1, 2019 · pp. 18–24 Read article
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Dissolution Enhancement in Nano/Micro-Sized Dispersions of Piroxicam with the Novel Polymer Soluplus® and Polyvinyl Pyrrolidone
Abstract: Piroxicam, a Non-Steroidal Anti-Inflammatory Drug (NSAID), belongs to the class II of the biopharmaceutical classification system (BCS) and thus exhibits poor bioavailability. In an effort to tackle this issue, we report here the comparative properties of the solid dispersions of piroxicam made from a novel graft copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) and the linear polymer polyvinyl pyrrolidone (K 25), both the dispersions synthesized identically using solvent evaporation method. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 1, 2012 · pp. 10–19 Read article
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Enhancement of Bioavailability of Clopidogrel Using Different Solubility Enhancement Techniques
Abstract: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Clopidogrel is a BCS class II drug. Drugs of this category have low solubility and high permeability, so their bioavailability is less. This can be overcome by doing pharmaceutic modifications on it. In the present study, three different modifications, namely, complexation, solvent deposition and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 25–39 Read article
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Dispersed Air Flotation for the Removal of Solids from Water
Abstract: The quest for clean drinking water is fundamental to our existence as without it, there is no life. This research exploits the feasibility of using principles of the state-of-the-art flotation technique for solid-liquid water clarification. Dispersed air flotation [DAF] as a separation technique, involves dispersing (scattering) compressed air at high pressure into water. A fluidic oscillator is employed to generate minute micro-bubbles from a 20 microns pore sized ceramic diffusers …
Published in Journal of Water Pollution & Purification Research · Vol. 6, Issue 2, 2019 · pp. 1–11 Read article
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Polymer Composite-Assisted Crystal Engineering for Drug Synthesis and Property Control through Solid Solutions and Co-Crystals
Abstract: The long-standing problem of low aqueous solubility, which affects about 90% of all new drug molecules under development, requires an immediate need for alternative approaches apart from the usual practice of crystallization. Polymer-composite-assisted crystal engineering is a novel technique for overcoming the aforementioned problem. This involves the addition of accepted pharmaceutical polymers, such as HPMC, PVP, PEG, and Eudragit copolymers in a single process, which can promote nucleation, stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 172–189 Read article
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Recent Advances in Delivering Strategies of Domperidone Challenges and Opportunities
Abstract: Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and limited oral bioavailability. Therefore, to develop oral preparations with optimized oral bioavailability, the pharmacokinetic parameters of DMP need to be controlled. The present review aimed to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, to explore the viable oral formulation approaches, and to propose some recent formulation approaches that can mitigate the above mentioned …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 13–24 Read article
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
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Pharmaceutical Syrup Formulation Enhancing Bioavaibility and Patient Compliance
Abstract: Pharmaceutical syrup formulations are crucial for drug delivery, especially in pediatric and geriatric populations. However, challenges, such as bioavailability, stability, and patient compliance due to factors, like taste and viscosity, must be addressed. Strategies to enhance bioavailability include solubility enhancers, nanoparticle systems, and advanced techniques like solid dispersions and emulsions. Palatability plays a critical role in patient compliance, with flavoring agents, sweeteners, and texture modifications improving acceptability. Innovations, like controlled-release …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 1–6 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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A smart fluids; Magneto rheological, ferrofluid, and nanofluids; a prospect for Medical and Technological application
Abstract: The physiochemical and biomedical applications of smart fluids, typically ferrofluid, magnetorheologicalfluids, and nanofluids are studied. It is predicted that these fluids are impacted by the three most important rheology parameters, namely strain, magnetic field, and temperature. The magnetoresistive contribution is treated in terms of drug force in order to determine thecoefficient of viscosity. The research presents that the viscosity of studied fluids will increase in proportion to applied magnetic field. …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 25, Issue 2, 2023 · pp. 47–57 Read article
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Nanostructured Lipid Carriers as a Potential Topical Drug Delivery Approach
Abstract: Topical drug delivery is a remarkable approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic in nature. For topical application of drugs generally application on skin is one of method of administration. But problem observed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 40–49 Read article