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Research & Reviews: A Journal of Drug Formulation, Development and Production Review Article

Pharmaceutical Syrup Formulation Enhancing Bioavaibility and Patient Compliance

  1. Mohd. Wasiullah Dept. of Pharmacy, Prasad Institute Technology, Jaunpur
  2. Piyush Yadav Dept. of Pharmaceutical Chemistry, Prasad Institute of Technology, Jaunpur
  3. Akash Yadav Dept. of Pharmacy, Prasad Polytechnic, Jaunpur

Abstract

Pharmaceutical syrup formulations are crucial for drug delivery, especially in pediatric and geriatric populations. However, challenges, such as bioavailability, stability, and patient compliance due to factors, like taste and viscosity, must be addressed. Strategies to enhance bioavailability include solubility enhancers, nanoparticle systems, and advanced techniques like solid dispersions and emulsions. Palatability plays a critical role in patient compliance, with flavoring agents, sweeteners, and texture modifications improving acceptability. Innovations, like controlled-release formulations and the use of nanotechnology, are advancing syrup efficacy. Regulatory aspects and case studies provide insights into successful formulations, while emerging research explores personalized medicine applications in syrup delivery systems.

Keywords

References (19)

  1. Golhen K, Buettcher M, Kost J, Huwyler J, Pfister M. Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics. 2023;15(4):1033. doi:10.3390/pharmaceutics15041033
  2. Spadoni C. Pediatric Drug Development: Challenges and Opportunities. Current Therapeutic Research. 2019;90:119-122. doi:10.1016/j.curtheres.2018.12.001
  3. Lou J, Duan H, Qin Q, Teng Z, Gan F, Zhou X, et al. Advances in Oral Drug Delivery Systems: Challenges and Opportunities. Pharmaceutics. 2023;15(2):484. doi:10.3390/pharmaceutics15020484
  4. Allen LV. Dosage form design and development. Clinical Therapeutics. 2008;30(11):2102-2111. doi:10.1016/j.clinthera.2008.11.015
  5. Yamashita F, Hashida M. In Silico Approaches for Predicting ADME Properties of Drugs. Drug Metabolism and Pharmacokinetics. 2004;19(5):327-338. doi:10.2133/dmpk.19.327
  6. Carstensen JT. Drug stability: principles and practices. Drugs Pharm Sci. 1990;43:X-520.
  7. Fahelelbom KM, El-Shabrawy Y. Analysis of preservatives in pharmaceutical products. Pharm Rev. 2007;5:1–55.
  8. VandenBerg CJ, Adams A, Bockrath R, Kim S, Rodriguez G, Fawcett A, et al. Hard to swallow: a review of interventions to improve swallowing solid medication. Hosp Pediatr. 2023;13(5):e123–132.
  9. Engel J, Heckler CE. Sensory and patient-centered formulation development. Adv Drug Deliv Rev. 2018;136:1–17.
  10. Shahiwala A. Formulation approaches in enhancement of patient compliance to oral drug therapy. Expert Opin Drug Deliv. 2011;8(11):1521–1519.
  11. Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. 2022;10(9):2055. doi:10.3390/biomedicines10092055
  12. Aqil F, Munagala R, Jeyabalan J, Vadhanam MV. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Letters. 2013;334(1):133-141. doi:10.1016/j.canlet.2013.02.032
  13. Douroumis D. Practical approaches of taste masking technologies in oral solid forms. Expert Opin Drug Deliv. 2007;4(4):417–426.
  14. Chauhan R. Taste masking: a unique approach for bitter drugs. J Stem Cell Biol Transplant. 2017;1(2):12–20.
  15. Mu Y, Zhao L, Shen L. Medication adherence and pharmaceutical design strategies for pediatric patients: an overview. Drug Discov Today. 2023:103766.
  16. CM J, Jîtcă G, Ősz BE, Pușcaș A, Imre S. Stability of oral liquid dosage forms in pediatric cardiology: a prerequisite for patient’s safety—A narrative review. Pharmaceutics. 2023;15(4):1306–1315.
  17. Binson G, Beuzit K, Migeot V, Marco L, Troussier B, Venisse N, et al. Preparation and Physicochemical Stability of Liquid Oral Dosage Forms Free of Potentially Harmful Excipient Designed for Pediatric Patients. Pharmaceutics. 2019;11(4):190. doi:10.3390/pharmaceutics11040190
  18. Marques L, Costa B, Pereira M, Silva A, Santos J, Saldanha L, et al. Advancing precision medicine: a review of innovative in silico approaches for drug development, clinical pharmacology, and personalized healthcare. Pharmaceutics. 2024;16(3):332.
  19. Serrano DR, Luciano FC, Anaya BJ, Ongoren B, Kara A, Molina G, et al. Artificial intelligence (AI) applications in drug discovery and drug delivery: revolutionizing personalized medicine. Pharmaceutics. 2024;16(10):1328.
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