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42 articles for “lung’s cells”
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Study of Anti-Cancer Activity of Leaves Extract of Murraya Koenigii in Human Lung’s Cells
Abstract: The extract of Murraya Koenigii commonly known as curry leaves in India was carried out to investigate the anti-cancer activity on human lung’s cells. The result shows positive indication of extract against lungs cancer cells efficiently with GI 50 value >80. The human lung’s cells were fixed in situ by the gentle addition of 50 μl of cold 30 % (w/v) TCA (final concentration, 10 % TCA) and incubated for …
Published in Research & Reviews : Journal of Herbal Science · Vol. 9, Issue 1, 2020 · pp. 24–28 Read article
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Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 07–22 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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Biological Property of Lung Clone Cell Strain “Pyong-09-2”
Abstract: We cultivated lung clone cell strain, “Pyong-09-2” whose genetic characters are proper from fetal lung tissue-originated lung cell strain and found out their biological property. Lung clone cell strain, “Pyong-09-2” formed monolayer in which polygonic epithelioid cells are arranged uniformly, like original cell strain “Pyong-09-2” and their growth rate and activity are highest in medium containing 1% serum in 24～84 h of culture. Their viral infectious titer, plaque forming ability, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 8, Issue 3, 2021 · pp. 29–34 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Utilizing circulation-derived cancer cells to evaluate patients with surgically treated stages I–IIIA NSCLC throughout the preoperative phase
Abstract: Context: When a tumor is considered resectable, surgery is viewed as the primary treatment approach for both early-stage and locally advanced non-small cell lung cancer (NSCLC). One of the most exciting areas of cancer research in the past ten years is liquid biopsy, which offers a practical non-invasive method for cancer detection and tracking. Circulating tumor cells (CTCs) have been linked to a worse prognosis and increased chance of relapse …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 17–28 Read article
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Clinical Significance of Immune Cells and T-cell Subsets in Lung Cancer
Abstract: Objectives: The aim of the study was to determine the clinical usefulness of pretreatment hematological parameters including neutrophils, lymphocytes, monocytes and immune T-cell subsets as well as calculated coefficients such as neutrophils-to-lymphocytes ratio(NLR),monocytes-to-lymphocytes ratio(MLR) and platelets-to-lymphocyte ratio(PLR)in patients with lung cancer. Materials and Methods: A total of 102 patients with lung cancer were prospectively analyzed. T-cell subsets were assessed by flow cytometry method. Peripheral blood was collected from 25 healthy …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 14–29 Read article
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Immunology and Immunotherapy of Pulmonary adenocarcinoma: A Systematic Review
Abstract: Lung cancer is the world's second leading cause of death, with an estimated 9.6 million deaths in 2018. Approximately 80% of all lung cancer is caused by non-small cell lung cancer (NSCLC). Due to lack of early detection and treatment, the incidence rate of lung cancer prognosis remains low. CD4+T-lymphocytes, macrophages, dendritic cells, and natural killer cells are among the immune cells involved in the pathogenesis of lung cancer. The …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 15–25 Read article
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Harnessing the Bioactive Potential of Calotropis gigantea and Calotropis procera
Abstract: The medicinal plants of the Apocynaceae family Calotropis gigantea and Calotropis procera have gained more and more interest as source of bioactive molecules for biomedical applications like cancer therapy. They have various pharmacological activities, which are believed to be linked to various phytochemical constituents such as cardenolides, cardiac glycosides, flavonoids, triterpenoids, steroids, phenolic compounds, alkaloids, and proteins in their latex. The recent molecular and cellular studies show that extracts and …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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In vitro Evaluation of Kigelia pinnata Leaves for Its Antioxidative and Anticancer Activity
Abstract: Previous studies suggest that the Kigelia pinnata leaves have useful effects against diseases mediated through oxidative stress and cancers. In this study, leaves of Kigelia pinnata were studied for presence of different phytochemical constituents, anti-oxidant and anti-cancer activities.Crude methane extracts of Kigelia pinnata leaves showed cytotoxic activity in vitro against non-small cell lung cancinoma (A-549) cells using the MTT assay. Phytochemical evaluation showed the existence of alkaloids, terpenoids, flavonoids, tannins …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 1, 2019 · pp. 26–30 Read article
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Development and Evaluation of Cost Effective Formula of Nintedanib Esylate Soft Gelatin Capsule and Compare with Prepared Product Similar to Innovator
Abstract: Nintedanib esylate was invented by Boehringer Ingelheim Pharmaceuticals. Nintedanib esylate is an organosulfonate salt obtained by combination of Nintedanib with ethane sulfonic acid. It’s a kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer. Bioavailability and water solubility of Nintedanib esylate is very low and BCS class is not mentioned in the literature. Due to poor solubility of Nintedanib esylate at neutral conditions, the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 3, 2018 · pp. 1–8 Read article
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Epitopes of Enzymes Involved in Sialylation with Special Reference to Lung Cancer
Abstract: Environmental pollutants, poor air quality, urban growth, deforestation, burning of fuel and indoor air pollution lead to different respiratory diseases including lung cancer with fatal consequences. Almost 2 million people die every year due to harmful effects of indoor air pollutants. Especially an enormous number of children are being affected. Environment pollution is not only reported to affect the lungs but also damage the stem cells and their niche thus …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 2, 2018 · pp. 11–19 Read article
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DETECTION OF LUNG CANCER USING SOFT COMPUTING TECHNIQUES
Abstract: Cancer is a generic term that can affect any part of the body. Most cancers, 90%-95%, are because by environmental and lifestyle variables which cause genetic mutations. Inherited genetics account for 5% to 10% of the total. Early identification of lung cancer has improved patient survival and has been a vital study topic. It starts within the cells covering the bronchi and lung parts like bronchioles or alveoli. Due to …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 1–12 Read article
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Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
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Analysis & Detection Kidney Stone Images using Fuzzy Techniques
Abstract: Kidney Stone is the most debilitating sort in one of the deadliest malignancies type of tumor. Over the a few years the occasion of dangerous tumor has consistently reached out, considering the way that the fix of the disease depends upon its fundamental judgment. Two noteworthy sorts of lung tumor, Small cell & Non-small cell Kidney Stone. The lungs are normally sweeping in measure along these lines tumors can create …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 8, Issue 2, 2021 Read article
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Hemoglobin is the Breath of Life within Our Cells: An Update
Abstract: Hemoglobin is a fascinating protein found in human red blood cells. This specialist protein carries oxygen from your lungs to every cell in your body, functioning as a little delivery system. While hemoglobin’s stronghold on oxygen is necessary, releasing it at the right time is a delicate challenge. This adaptable protein masterfully balances holding on to its oxygen cargo or releasing it swiftly. This article explores how hemoglobin achieves this …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 25–31 Read article
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The effective therapeutic strategies to fight against COVID-19 in India
Abstract: In December 2019, the global pandemic coronavirus infection (COVID-19) was first detected in Wuhan, Hubei Province, Central China. It is caused by coronavirus-2, which causes severe acute respiratory syndrome (SARS-CoV-2). This was declared by World Health Organization on 11th March 2020. In India, the first case of COVID-19 infection was reported in Kerala on January 27,2020 of a 20 yr old female presented to an Emergency Department in General Hospital, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 12, Issue 1, 2022 · pp. 43–49 Read article
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QSAR Studies of 3-(4-(3-(Substitutedphenyl) Acryloyl) Phenyl)-2-Substituted phenyl/Phenylthiazolidin-4-ones for Anticancer Activity
Abstract: Both, Chalcone and 4-thiazolidinone, are therapeutically significant organic moieties with anticancer activities. QSAR (Quantitative structure–activity relationship) studies of ten synthesized chalcone-thiazolidinone hybrids have been described for anticancer activity against three cancer cell lines: A-549 (Human lung adenocarcinoma), U-87 MG (Human glioblastoma cancer cells) and COLO-205 (Human colon cancer cells). The developed linear QSAR models have significant statistical quality showing good fitting ability and robustness. The Q2 and R2 values of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 3, 2016 · pp. 16–22 Read article
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A Comprehensive Review of Ethnobotanical Studies on Traditional Indian Herbal Plants for Lung Cancer Management
Abstract: Lung cancer is a leading cause of cancer-related deaths in the world. Current therapies for lung cancer are often limited by many side effects. This review compiles and evaluates ethnobotanical evidence and modern scientific findings of Indian herbal plants traditionally used for respiratory and tumor-related disorders, with a focus on their relevance to lung cancer management. Herbal phytochemicals and how they show their potent activities were also listed in this …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 1–7 Read article
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Advances in Lung Cancer Detection and Diagnosis: An Integrative Approach Using Computational Chemistry, Statistics, Bioinformatics, Artificial Intelligence, and Machine Learning
Abstract: Lung cancer is still one of the most common and lethal cancers globally, accounting for more than a million deaths each year. Prompt detection is important, and imaging techniques like chest X-rays, MRIs, PETs, CTs, and molecular imaging have become important tools. But still, even though all these techniques do not provide an accurate classification of the lesion, they have led to the development of computer-based high-resolution image analysis. Computer …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article