Search
89 articles for “in-vitro release study”
-
Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–14 Read article
-
The Effect of Shear Bond Strengths and the Mode of Bond Failure in Metal and Ceramic Brackets Bonded with Fluoride Releasing Composites: An in vitro Comparative Study
Abstract: One of the standard measures in the prevention of enamel demineralization is the use of Fluoride. Fixed orthodontic attachments act as a retentive area for plaque accumulation that leads to development of white spot lesions (WSLs). Incorporation of fluoride into adhesives for bracket bonding inhibitsdemineralization during fixed orthodontic treatment. However, the addition of fluoride into orthodontic adhesives may affect the mechanical properties such asshear bond strength (SBS). The present study …
Published in Research and Reviews: A Journal of Dentistry · Vol. 11, Issue 1, 2020 · pp. 1–7 Read article
-
Formulation and Evaluation of Microballoons of Ramipril
Abstract: The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 13–30 Read article
-
Once a Day Pellets of Theophylline by Extrusion Spheronization Technique Using Gelucire® Matrix
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Theophylline, a xanthine bronchodilator has narrow therapeutic index (5 – 15 µg/mL). The aim of the present work was to prepare once a day pellets of theophylline …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 Read article
-
Formulation and Evaluation of Buccal Mucoadhesive Bilayered Tablets of Enalapril Maleate
Abstract: The buccal mucoadhesive bilayered tablets of Enalapril Maleate were fabricated with objective of avoiding first pass metabolism and prolonging the duration of action. The tablets were prepared by wet granulation wherein, one layer comprised of drug and bio adhesive polymer, whereas second layer consisted of drug free backing layer of ethyl cellulose. Bioadhesive polymers like Carbopol 934P and one either of three HPMC K4M/ HPMC K15M/ HPMC K100M were employed …
Published in Trends in Drug Delivery · Vol. 1, Issue 1, 2014 · pp. 1–15 Read article
-
Formulation and Evaluation of Microencapsulated Levofloxacin Gel
Abstract: To treat various buccal infectious diseases, a sustained release microencapsulated levofloxacin gel was formulated. Levofloxacin microspheres were being prepared following o/w emulsion solvent evaporation technique by varying concentrations of ethyl acetate, ethyl cellulose and tween 80. Depending on their flow properties almost all the microspheres were found to be excellent. The drug-excipient compatibility study carried out using Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) resulted that the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 39–47 Read article
-
Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation
Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 1–20 Read article
-
Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil Smita D Patel*, M R Patel, K R Patel
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–15 Read article
-
Self-Nanoemulsifying Drug Delivery System for Atorvastatin Calcium: Design, Optimization and Evaluation
Abstract: Atorvastatin calcium (ATC) is the choice of drug in the treatment of moderate to severe hypercholesterolemia. In the current study, ATC self-nanoemulsifying drug delivery systems (SNEDDS) were prepared in an attempt to improve the bioavailability by enhancing its solubility. The solubility of ATC in various oils, surfactants, and co-surfactants were determined. Based on their solubility, Capmul MCM (oil), Tween 20 (surfactant), propylene glycol (Co-surfactant) was selected for preparation of SNEDDS. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 27–36 Read article
-
Design and Evaluation of Itraconazole Niosomes
Abstract: The present study was undertaken with an aim to fabricate and characterize and evaluate niosomes of Itraconazole, where the drug is released in a sustained manner for a period of 12 hours. Itraconazole is Class-2 drug having low solubility and have short half-life between 3–4 hours. Due to high first pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained release delivery. To overcome these …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 62–68 Read article
-
Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
-
Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
-
Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article
-
Formulation Development of Meloxicam Loaded Transdermal Patches and Their Evaluation
Abstract: The current studies aim the Formulation and development of transdermal patches of Meloxicam. Meloxicam is a Non- Steroidal Anti-inflammatory Drug. Transdermal patches show better patient compliance over conventional dosage forms because of their longer time of operation resulting in a reduction in less frequent dosing. Six batches of transdermal patches were prepared using different concentrations of hydroxyl propyl methyl cellulose, ethyl cellulose, and polyvinyl pyrrolidone to increase the physical properties …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 12–22 Read article
-
Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
-
Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
-
Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
-
Enhancement of Bioavailability of Clopidogrel Using Different Solubility Enhancement Techniques
Abstract: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Clopidogrel is a BCS class II drug. Drugs of this category have low solubility and high permeability, so their bioavailability is less. This can be overcome by doing pharmaceutic modifications on it. In the present study, three different modifications, namely, complexation, solvent deposition and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 25–39 Read article
-
Drug Delivery Systems and Innovations
Abstract: The aim of this study was to develop a controlled release system targeting antibiotic distribution to the stomach. The hydrogels were synthesized by utilizing chitosan, poly(acrylic acid) and poly(vinyl pyrrolidone) polymers cross linked with glutaraldehyde and N,N′-methylene bisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were compare by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly(acrylic acid), poly(vinyl pyrrolidone) and N, N’-methylenebisacrylamide were kept constant in all formulations. …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 10–20 Read article
-
Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article