Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation

Tushar Dilip Sonawane; S.P. Pawar

Abstract

The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical evaluation of compressed tablet was performed and found satisfactory. The optimized formulation F8 containing HPMC (Metolose SR 90SH-15000) and xanthan gum (1:2) and in vitro drug release study showed sustained drug released for 9 Hours. Optimization study was performed by using design of experiment (DoE). In vitro drug release study data revealed that combination of Metolose SR 90SH-15000 (30 mg) and Xanthan Gum (60 mg) along with diluent dibasic calcium phosphate (41 mg) shown desired drug release profile with sustained manner. The approach describes the efficiency of bioadhesive polymer to adhere the mucous lining and prolong the drug release. Backing layer of ethyl cellulose (EC) was used to provide unidirectional drug release. The in vitro release kinetics reveals that formulation follows Korsmeyer–Peppas model. Optimized formulation was stable for1 month accelerated stability condition at 40°C and 75% RH.

Abstract

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