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264 articles for “clinical applications”
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A Study of Optical Sensor in Clinical applications
Abstract: The escalating demand for precise, real-time, and minimally invasive diagnostic and monitoring tools in clinical practice has propelled the development of sophisticated sensor technologies. Among these, optical sensors have emerged as a cornerstone, leveraging the interaction of light with biological matter to translate molecular or cellular events into quantifiable signals. Their inherent advantages – including high sensitivity, specificity, rapid response times, non-ionizing nature, and potential for miniaturization – make them …
Published in International Journal of Optical Innovations & Research · Vol. 3, Issue 2, 2025 · pp. 1–7 Read article
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Cosmetic Topical Formulations: Design Strategies, Skin Interaction Mechanisms, Clinical–Cosmetic Applications, and Emerging Trends
Abstract: Cosmetic topical products are central to modern skin care, as they deliver active ingredients directly to the skin surface and upper layers to improve appearance, texture, and function. By acting locally on the epidermis and adnexal structures, these preparations help manage dryness, photoaging, pigmentation, acne, and sensitive-skin conditions while minimizing systemic exposure. A wide range of dosage forms—creams, lotions, gels, ointments, serums, sprays, and transdermal-inspired cosmetic patches—are engineered to modulate …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 39–47 Read article
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Refining Retinal Layer Segmentation in OCT Imaging with Advanced Techniques and Clinical Applications
Abstract: Segmenting retinal layers from Optical Coherence Tomography (OCT) pictures entails locating and separating different retinal layers to offer comprehensive anatomical and pathological information. Age-related macular degeneration, diabetic retinopathy, and glaucoma are among the retinal illnesses for which this procedure is crucial for diagnosis and follow-up. By utilizing preprocessing techniques to improve image quality and applying advanced algorithms—such as intensity-based, gradient-based, and texture-based methods—alongside deep learning approaches, clinicians can accurately measure …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 2, 2024 · pp. 01–06 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Polymer Based Optoelectronics in Clinical Application Treated with Sodium Fluoride and Aqueous Dimethyl Sulfoxide Solutions
Abstract: In polymer science, dimethyl sulfoxide (DMSO) and sodium fluoride (NaF) are frequently combined to dissolve, modify, or treat particular polymers, most notably in the processing of cellulose and the creation of polyvinylidene fluoride (PVDF) membranes. The viscosities, ultrasonic velocities, and sodium fluoride densities of aqueous solutions of dimethyl sulfoxide (DMSO) have been measured at T=303.15, 308.15, 313.15, and 318.15 K. Fluorides (such as NaF or TBAF) help break inter-chain hydrogen …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 20–29 Read article
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Pharmacogenomics and Precision Medicine: An Evolving Analytical Clinical Tools for Future Medicine – A Narrative Review
Abstract: The term Pharmacogenomics is coined as an emerging field that exactly examines how the genetic variations influence the individual responses towards medications. This discipline in turn integrates the pharmacology as well as genomics to facilitate the personalized medicine, encouraging the healthcare providers to tailor their drug therapies based on individual patient’s genetic profile. Key applications include optimizing drug efficacy, minimizing adverse effects, and enhancing treatment outcomes across various medical fields, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 44–52 Read article
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Gene Therapy 2.0: Harnessing Cutting-Edge Technologies for Precision Medicine
Abstract: Somatic gene therapy has become the standard form of gene therapy; this creates the Gene Therapy 2.0 era. This new and distinct time consists in the new-generation genome-editing tools and markers, more efficient systems for gene delivery, and personalized medicine approaches that raise the efficacy and safety of the treatment. Base and prime editing are two types of CRISPR-based gene editing tools have provided high precision and reduced off-target effects …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Clinical study on application of hemorrhoidectomy by anal canal dilatation for Grade III or IV internal hemorrhoid accompanied anal fissure
Abstract: Purpose: We established new surgical approach (Hemorrhoidectomy by anal canal dilatation) for Grade III or IV internal hemorrhoid accompanied anal fissure. Methods: We analyze the clinical result of this operation method. Results: The average recovery rate with the technique used in the study was 95.8% compared with the Milligan-Morgan technique of 86.8%, and the postoperative analgesic use rate and duration of difficulty in defecation were also less. Conclusion: These results …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 54–60 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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AI Approaches in Gait and Posture Analysis: A Review
Abstract: This review synthesizes current research on the application of artificial intelligence (AI) in gait and posture analysis, focusing on methodologies, algorithms, and clinical applications. It examines the use of machine learning (ML) and deep learning (DL) techniques to extract relevant features from sensorderived data, offering objective, and automated assessments that surpass traditional methods. A systematic literature review was conducted, analyzing studies that utilized AI for gait and posture analysis with …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 1–3 Read article
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Engineered Polymer Composites for Non-Surgical Lip Posture Correction in Facial Paralysis
Abstract: Facial paralysis presents significant functional and aesthetic challenges, particularly through lip posture deficits such as drooping and drooling, often inadequately addressed by traditional surgical or drug-based interventions, especially in debilitated patients. This study explores the application of engineered polymer composites in a novel, non-surgical lip posture corrector designed to statically suspend and correct lip position without requiring surgical or dental support. The device utilizes a precisely formulated blend of polymethylmethacrylate …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
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Effect of Snehpana (Lipid Based Drug Delivery System) with Shatpala Ghrit in Non-Alcholic Fatty Liver Diseases
Abstract: Among all the Drug Delivery Systems, Snehpana (~Lipid Based Drug Delivery System) is being widely used because this facilitates uniform distribution and absorption of fat and water-soluble chemical constituents. Due to their effective size-dependent properties and challenges related to the solubility and bioavailability of water-soluble drugs, this system holds a significant advantage. Numerous studies have highlighted the potential of lipid-based formulations in managing chronic and life-threatening diseases. Shatpala ghrit (SG) …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 1–11 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Comparative Analysis and Future Research Directions in AI in Healthcare: Medical Imaging and Diagnostics
Abstract: Artificial intelligence (AI) is reshaping healthcare, particularly in the areas of medical imaging and diagnostic practice. By using advanced techniques like machine learning and deep learning, AI systems help improve the accuracy, speed, and effectiveness of identifying diseases and analyzing medical images. This paper provides a comprehensive overview of the application of artificial intelligence in medical imaging and highlights its growing importance in clinical diagnostics. It discusses how AI-based systems …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 8–13 Read article
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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A Dual-Model Deep Learning Framework for Early Alzheimer’s Detection Using Clinical Data and Neuroimaging with Architectural Performance Analysis
Abstract: Alzheimer’s disease (AD) poses a significant global health challenge due to its increasing prevalence and the absence of definitive cures. Early diagnosis is crucial for effective intervention and management. This study presents a dual-model deep learning framework for the early detection and classification of AD using both structured clinical data and neuroimaging datasets. Model 1 utilizes a greedy layer-wise autoencoder approach applied to structured data, achieving optimal binary classification accuracy …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 1–12 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article