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773 articles for “MMP-9”
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In-Silico Docking of Rubia cordifolia Phytocompounds as Potential MMP-2 Inhibitors for Varicose Vein Management
Abstract: Varicose veins are one of the most common disorders, affecting the vein structure and function of lower limbs, yet there has been no absolute cure found yet. One of the underlying causes for worsening of the condition is the proteolytic activity of MMPs which are a group of enzymes that affect the extracellular matrix (ECM) surrounding the affected veins. Phytocompounds of Rubia cordifolia (Manjishta) were docked against the MMP-2 protein …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 31–42 Read article
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Rheumatoid Arthritis and Stem Cell Therapies Perspectives for It
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation, primarily affecting synovial joints, leading to joint destruction and systemic complications. The pathogenesis involves immune system dysregulation, autoantibody production, and enzymatic imbalances. Enzymes, including matrix metalloproteinases (MMPs), serine proteases, and kinases, play crucial roles in these processes. Their dysregulation contributes significantly to disease progression through the imbalance of pro-inflammatory cytokines, oxidative stress, and extracellular matrix (ECM) degradation. MMPs, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 Read article
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Effect of 940-nm Low-Level Laser Therapy on Tooth Movement Rate during Orthodontic Treatment: A Split-Mouth Double-Blind Randomized-Controlled Trial
Abstract: This study aimed to evaluate the effect of low-level laser with wavelength of 940 nm on acceleration of orthodontic tooth movement. Materials and Methods: This study was a double-blind randomized-controlled trial with split-mouth design. Fifty-five patients whose four first premolars were extracted for orthodontic treatment were randomly allocated to group A (n = 27) and group B (n = 28). Canine retraction was performed using the force of 150 g …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 3, 2024 · pp. 14–20 Read article
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A 9-level type as multi-based invertor of the transformer and types of topolgy with analysis & comparision.
Abstract: In this paper presents information about the transformer as a multi-based investor. We are using the proposel of the 9-level invertor. In this inverter we are used the various type of switches. Such operation will be used of this transformer, we give input of one dc voltage source to output is the good quality of power. For the 9-level invertor one input as dc source will give the 9 level …
Published in Journal of Power Electronics and Power Systems · Vol. 15, Issue 1, 2025 · pp. 37–43 Read article
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High Frequency Design Approach and Feasibility Study of HBT Based W-band (90.0 GHz-100.0 GHz) Amplifier using 130 nm SiGe Based BiCMOS Technology
Abstract: This paper present high frequency design approach and feasibility study of HBT (Hetero Junction Bipolar Transistor) based two-stage cascode amplifiers at W-band (90.0 GHz-100.0 GHz). The proposed amplifier has design using 130 nm SiGe based BiCMOS technology. This paper used low cost technology for designing of w-band amplifier and this is novelty of this paper. The schematic design and feasibility study has been carried out using Cadence software. The selection …
Published in International Journal of Digital Communication and Analog Signals Read article
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Design and Simulation of LNA in 90 nm CMOS Technology for Radio Receiver using the Cadence Simulation Tool
Abstract: Due to its successful operation in the 2.4 GHz frequency region, often known as the ISM (Industrial, Scientific, and Medical) band, RFICs play a vital role in communication systems. The major parts being used transceivers for frequency translation and amplification are LNA and Mixers. Different types of mixers and LNAs are employed, and different strategies are used to optimize them. In this paper an approach for design and simulation of …
Published in International Journal of Digital Communication and Analog Signals Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Gradient Boosted Regression Tree Approach to Predicting Toxic Interactions on X and YouTube
Abstract: In the digital age, social media platforms play a vital role in facilitating user engagement, encompassing both positive interactions and avenues for negative, often harmful behaviors. Recognizing and addressing toxic exchanges is paramount to nurturing healthy online communities and preserving users’ well-being. This study introduces a novel method for identifying toxic interactions by utilizing Gradient Boosting Regression Trees (GBRT) algorithm, a machine learning approach renowned for its exceptional accuracy and …
Published in Trends in Opto-electro & Optical Communication · Vol. 15, Issue 3, 2025 · pp. 7–14 Read article
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Assessing the Effectiveness of New Fungicides Against Potato Late Blight Disease (Phytophthora Infestans)
Abstract: An experiment was conducted in the field of the Plant Pathology Division, Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), Jamalpur, Bangladesh during the rabi season of 2024–2025 to determine the appropriate chemical fungicide for controlling late blight disease of potato. The evaluation included twenty-five new fungicides approved by the Pesticide Technical Advisory Committee (PTAC), Bangladesh, along with a standard control (Ridomil Gold MZ 68 WG) and an …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 15, Issue 1, 2026 · pp. 28–38 Read article
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Evaluation of Mucoadhesive Polymers for Nasal Delivery of Herbal Bioactives
Abstract: A study assessed mucoadhesive polymers for intranasal herbal bioactive administration with higher residence time and mucosal permeability. Chitosan, Carbopol® 934P, and HPMC K15M were utilized to manufacture mucoadhesive nasal gels with standardized herbal bioactive fractions. Formulations were examined for pH, viscosity, spreadability, drug content, mucoadhesive strength, in-vitro release, ex-vivo penetration, and short-term stability. All formulations demonstrated a suitable pH for nasal usage and uniform drug content (97.48 ± 1.12% to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1680–1689 Read article
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Navigating Risk-Based Approaches in Quality Assurance: Strategies, Implementation, and Impact
Abstract: This review investigates the implementation of a risk-based approach within Quality Management Systems (QMS) as stipulated by ISO 9001:2015 regulations. It scrutinizes the challenges organizations encounter when transitioning to ISO 9001-2015 requirements, particularly focusing on the alignment of conceptual frameworks and processes among stakeholders. A key objective of this review is to propose a refined definition of "quality risk" and "risk-based thinking in QMS" to address the idiosyncratic characteristics of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 Read article
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Optimizing Sentiment Analysis with Naïve Bayes and Random Forest Techniques: A Result-based Approach
Abstract: In the increased digitalization, the sentiment analysis and classification have evolved as an eminent area to determine the polarity of positive, negative, and neutral reviews of the customers and users on products. It is an integral application field that employs supervised learning, Machine Learning, and Natural Language Processing concepts. The proposed Semantic Analysis and Classification using Naive Bayes and Random Forest system accomplishes the sentiment polarity by classifying the user …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 2, 2025 · pp. 46–57 Read article
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A summary continuation analysis evaluating the prevalence and predictors of diabetic retinopathy in newly diagnosed type 2 diabetic patients.
Abstract: Context: Diabetic retinopathy (DR), the leading cause of acquired blindness in adults, affects approximately 93 million people globally. It is a serious complication of type 2 diabetes, resulting from prolonged damage to the blood vessels in the retina. Although largely preventable and treatable, DR continues to be the main cause of vision loss among working-age adults and significantly impacts quality of life. While most studies on DR in Nepal have …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 21–30 Read article
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Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel
Abstract: This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
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Academic Performance and Its Associated Factors Among Pawe Health Science College Students in Benishangul-Gumuz Regional State, North-West Ethiopia
Abstract: Background: Academic performance can be defined as the degree to which a teacher, an institution, or a student meets short-term or long-term learning objectives. Continuous assessments and the student’s overall cumulative grade point average (CGPA) are typically used to measure academic achievement. Objectives: To assess academic performance and its associated factors among students, in the case of Pawi Health Science College, Benishangul-Gumuz Regional State, North-West Ethiopia, 2025. Methods: An institution-based …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 · pp. 24–35 Read article
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Effect of Particle Size Mix Ratio of Clay and Agro-Based Material for AGO and PMS Treatment on Microbial Growth
Abstract: The characteristics of possible microbes isolated and identified on adsorption process involving AGO and PMS as contaminants in fresh water medium was monitored using agro – based materials. The formulated adsorbent is made of clay with ago-based materials of Banana Ogoni Red (BOR) Banana Native (BN), Plantain Agbagba 1 (PA1), and Plantain Ogoni Red (POR). The particle size mixed ratio of clay to the various agro-based materials were 150𝜇𝑚 R5:5, …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 2, 2024 · pp. 05–14 Read article
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Synthesis of Activated Carbon from Corn Cob and Factors Affecting its Adsorption and Desorption Efficiency of Cationic Brilliant Green Dye
Abstract: Extreme dye pollutants released from textile, leather, and pulp industries are becoming a major concern to the water. These pollutants are highly toxic to living things. The major objective of this study was to prepare low-cost and efficient activated carbon from corncob (CCAC) adsorbent through the H2SO4 activation method and characterize its suitability for removing brilliant green dye (BGD) from aqueous solution. The adsorption and desorption efficiency of the prepared …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 27–44 Read article
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Enhanced Mechanical and Tribological Performance of Magnesium–Boron Carbide Composites Fabricated via Stir Casting for Lightweight Structural Applications
Abstract: This study investigates the fabrication and evaluation of properties of magnesium (Mg) matrix composites reinforced with boron carbide (B₄C) for lightweight structural applications. Stir casting was employed to incorporate B₄C particles at varying weight fractions (0%, 3%, 6%, and 9%) into the magnesium matrix. The influence of B₄C on density, porosity, hardness, tensile strength, and wear resistance was systematically examined. Theoretical density increased from 1.74 g/cm³ (pure Mg) to 1.88 …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 29–39 Read article
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Efficacy of New Fungicides in Controlling Powdery Mildew of Sweet Gourd
Abstract: This experiment was conducted at the Plant Pathology Division, Regional Agricultural Research Station (RARS), Jamalpur, Bangladesh during 2025 of Rabi & Kharif-1 seasons to find out the effectiveness of new fungicides against Powdery mildew disease of sweet gourd. Twenty (20) new fungicides viz. Acrozet 50 WP, Qingdao GBW, Hea 10 FC, Top star 32.5 SC, Nila 80 WP, Soazeb 72 WP, Safezeb 80 WP, Canvas 32.5 SC, Pyzim 50 WP, …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 134–142 Read article
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Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article