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146 articles for “Drug utilization studies”
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Drug Utilization Study of Anti Rheumatoid Drugs in Patients with Rheumatoid Arthritis at a Tertiary Care Hospital
Abstract: Background: Rheumatoid arthritis (RA) is a chronic disease that is classified as an autoimmune illness. It is characterized by joint inflammation, which can subsequently cause joint destruction. This leads to disability and a decline in quality of life. An analysis of drug usage is an important way of assessing prescribing habits and evaluating the rationality of drug use in an effort to achieve optimal therapeutic results among RA patients. Objectives: …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 4, Issue 1, 2026 · pp. 14–20 Read article
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A Study and Report on Due (Drug Utilization Evaluation) of Cardiovascular and Endocrine Disorders/Diseases in Inpatient Units of Hospitals
Abstract: In recent years drug utilization studies have become a potential tool to be used in the evaluation of health systems. On the process of drug utilization studies focus on factors related to prescribing, dispensing, administering, and taking of medication, and its associated events. Drug utilization data are available from databases- computerized or otherwise. From these databases different types of information, qualitative or quantitative or referring to a particular population are …
Published in Trends in Drug Delivery · Vol. 8, Issue 3, 2023 · pp. 11–32 Read article
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Prescribing Patterns of Analgesics in Surgical Departments in a Tertiary Care Hospital
Abstract: Analgesics are routinely employed in the management of pain in surgical departments. Drug utilization studies evaluate the present trends of drug usage, drug expenditures, appropriateness of prescriptions and adherence to evidence-based recommendations. The Objectives were to study the prescribing pattern, approval status, inclusion in World Health Organization (WHO) essential medicines list/National List of Essential Medicines (NLEM), cost and rationality of analgesics prescribed in surgical departments. Data were collected from records …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 9–16 Read article
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To Study The Drug Utilization Pattern of Drugs Used in Treatment of Thyroid Patients in Tertiary Care Hospital, Bathinda
Abstract: Aim: This study aimed to assess the drug prescription trends for thyroid disorders in a tertiary care setting, with a focus on medication choice, dosage patterns, and patient self-medication behaviour. Methods: A prospective observational study was conducted on 84 patients diagnosed with thyroid disorders. Data were collected regarding the type of disorder, prescribed drugs (dose and frequency), comorbidities, and self-medication practices. Descriptive statistics were applied to identify prescription trends. Results: …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 59–66 Read article
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A Review on Impact of DUE (Drug Utilization Evaluation) in Promotion of Rational Drug Prescribing in India
Abstract: In recent years drug utilization studies have become a potential tool to be used in the evaluation of health systems. On the process of drug utilization studies focus on factors related to prescribing, dispensing, administering and taking of medication, and its associated events. Drug utilization data are available from databases- computerized or otherwise. From these databases different types of information, qualitative or quantitative or referring to a particular population are …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 2, 2023 · pp. 1–12 Read article
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Drug Utilisation and Cost Analysis in End-Stage Renal Disease Patients: A Prospective Observational Study
Abstract: Chronic Kidney Disease (CKD) is a condition in which the kidneys are damaged and unable to efficiently remove waste and excess fluid from the blood. Dialysis serves as a treatment for CKD by artificially carrying out the kidney’s filtering functions. This prospective observational cross-sectional study was conducted to evaluate drug utilization patterns, economic burden, and health-related quality of life (HRQoL) among patients with end-stage renal disease (ESRD) undergoing dialysis. Over …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 · pp. 1–12 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Patterns of Antihypertensive Drug Utilization in a West Indies University Teaching Hospital
Abstract: Objective of this study was to determine the prescribing patterns of antihypertensive medications in specialty outpatient clinics in a tertiary care hospital of a Caribbean developing country. A retrospective prescription-based survey was conducted in the renal and cardiac outpatient clinics during the period September to December 2006. Data recorded included demographic data, antihypertensive and other drugs prescribed, duration of prescription, adverse drug reactions and side effects. A total of 285 …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 5, Issue 1, 2014 · pp. 26–34 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Emerging Therapeutic Discovery Against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of Some Metabolites as Inhibitors of Fatty Acid Metabolism Protein
Abstract: For the discovery of effective agent for overcoming resistance against Escherichia coli (E. coli) bacteria by modulating Fatty Acid Metabolism Protein (FadR)—a Fatty Acid Responsive Transcription Factor. The present study involved discovery of some metabolites of furan, furan-2-yl, macrolactin, and chromene scaffold via in silico structure-based drug design (SBDD) technique by utilizing the Maestro 9.1 software. The study will provide clues, motivate, and throw light on imperative aspects for the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 1–7 Read article
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Network Pharmacological Studies in Biological Interactions of Thymoquinone
Abstract: Thymoquinone, a bioactive phytochemical compound belonging to the class of benzoquinones, is prominently present in the plant Nigella sativa. Despite its widespread use, the precise molecular mechanisms underlying its beneficial effects remain elusive. To address this gap, we employed network pharmacology to investigate the actions of Thymoquinone (TQ). Our methodology encompassed the utilization of diverse bioinformatic tools to scrutinize this molecule of interest comprehensively. Initially, we retrieved the chemical structure, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 18–25 Read article
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Drug Delivery Systems and Innovations
Abstract: The aim of this study was to develop a controlled release system targeting antibiotic distribution to the stomach. The hydrogels were synthesized by utilizing chitosan, poly(acrylic acid) and poly(vinyl pyrrolidone) polymers cross linked with glutaraldehyde and N,N′-methylene bisacrylamide. Interpenetrating polymeric network (IPN) hydrogels were compare by varying the concentration of crosslinking agent (glutaraldehyde). The amount of chitosan, poly(acrylic acid), poly(vinyl pyrrolidone) and N, N’-methylenebisacrylamide were kept constant in all formulations. …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 10–20 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Antibiotics Utilization Pattern in Pediatric Ward of Ghimbi Adventist Hospital, Ghimbi Town, Oromia Region, West Ethiopia
Abstract: Drug use evaluation is ongoing systematic process designed to maintain the appropriate and effective use of drugs. It is used to ensure that drugs are used appropriately, safely and effectively to improve patients’ health status. The general objective of the study was to assess antibiotics utilization patterns in pediatric ward of Ghimbi Adventist Hospital (GAH), Ghimbi town, Oromia region, West Ethiopia.A hospital-based retrospective cross-sectional study was conducted to assess the …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 19–30 Read article
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article
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Access to Health and Support Systems: Role of NGOs in Facilitation Process among Injecting Drug Users (IDUs) in Bilaspur
Abstract: In Chhattisgarh, Bilaspur has a high prevalence of Injecting Drug Use and it is associated with HIV/AIDS infection, which is fast increasing. There is an urgent need to understand the treatment seeking behaviour of IDUs. Various services and treatment options are in place for IDUs in Bilaspur. Both Government and NGOs are active in spreading awareness and providing necessary support to the drug users. But formulating policies and setting-up establishments …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 1–6 Read article
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Formulation and Development of Ibuprofen Floating Tablet
Abstract: The investigation focused on optimizing a gastric floating drug delivery system (GFDDS) for Ibuprofen tablets. It employed polymers like HPMC K4M and Carbopol 940 to improve Ibuprofen's bioavailability and therapeutic effectiveness. GFDDS, with lower bulk density than gastric fluids, remains buoyant in the stomach, extending gastric residence time. Compatibility assessments, via DSC analysis, indicated harmony between the polymers used, with no observed interaction between the polymer and the drug. The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 24–29 Read article
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Study on Vitamin D Deficiency and Hypocalcemia in Chronic Kidney Disease Patients in a Tertiary Care Hospital: A Single-Centered Study
Abstract: Background: Patients with chronic kidney disease (CKD) suffers from multiple comorbidities such as hypertension, diabetes mellitus, coronary artery disease and pyelonephritis. The most commonly accompanied complications are Vitamin D deficiency (VDD) and hypocalcemia that require multiple medications. This study evaluated the number of patients suffering from VDD and hypocalcemia and also analysed the utilization pattern of Calcium and Vitamin D supplements in CKD patients. Objectives: To evaluate the number of …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 3, 2019 · pp. 20–24 Read article
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A Combined Molecular Docking Analysis of The Phytochemicals of Ginkgo biloba against The Parkin Protein Target (Autoinhibited Parkin Catalytic Domain)
Abstract: This study's goal is to evaluate the specific therapeutic targets for Parkinson's disease (PDB ID: 4BM9) using molecular docking simulation and ADME analysis against bilobalide, quercetin, ginkgolide B, and protocatechuic acid (3,4-Dihydroxybenzoic acid). The Protein Data Base was used to extract theprotein's three-dimensional structure, and the PubChem database was used to retrieve the ligands. Using Auto-Dock Tools-1.5.7, a molecular docking simulation of the compounds was carried out. Since none of …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 1–9 Read article