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Research and Reviews : Journal of Computational Biology

Emerging Therapeutic Discovery Against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of Some Metabolites as Inhibitors of Fatty Acid Metabolism Protein

  1. Tomy Muringayil Joseph
  2. Debarshi Kar Mahapatra

Abstract

For the discovery of effective agent for overcoming resistance against Escherichia coli (E. coli) bacteria by modulating Fatty Acid Metabolism Protein (FadR)—a Fatty Acid Responsive Transcription Factor. The present study involved discovery of some metabolites of furan, furan-2-yl, macrolactin, and chromene scaffold via in silico structure-based drug design (SBDD) technique by utilizing the Maestro 9.1 software. The study will provide clues, motivate, and throw light on imperative aspects for the globally working medicinal chemists in the rational designing of anti-infective drugs in the near future. Keywords: Chromene, FadR, furan, furan-2-yl, macrolactinCite this ArticleJoseph TM, Mahapatra DK. Emerging Therapeutic Discovery against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of some Metabolites as Inhibitors of Fatty Acid Metabolism Protein. Research & Reviews: Journal of Computational Biology. 2018; 7(3): 1–7p

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