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238 articles for “Clinical Safety”
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article
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Reward-Aligned Reinforcement Learning from Human Feedback for Emotion-Sensitive Large Language Model Therapists: Balancing Empathetic Engagement, Boundary Safety, and Clinical Accountability
Abstract: The deployment of large language models (LLMs) in mental health therapy contexts introduces a critical alignment challenge: these systems must simultaneously cultivate genuine empathic rapport, observe clinically grounded safety boundaries, and remain auditable under institutional accountability frameworks. Existing reinforcement learning from human feedback (RLHF) pipelines optimize for a scalar reward signal that is demonstrably insufficient for the multi-objective, temporally extended nature of therapeutic conversation. This paper presents RA-RLHF-T (Reward-Aligned RLHF …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 2, 2026 Read article
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Effectiveness of Evidence-Based Pediatric Nursing Practices on Clinical and Developmental Outcomes in Children: A Comprehensive Systematic Review
Abstract: Evidence-based pediatric nursing practices are essential for improving health outcomes among children by integrating clinical expertise with the best available research evidence and patient-centered care approaches. This systematic review examines the effectiveness of evidence-based pediatric nursing interventions on clinical and developmental outcomes in children across various healthcare settings. A comprehensive search of databases including PubMed, CINAHL, Scopus, and the Cochrane Library was conducted for studies published between 2016 and 2026. …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 4, Issue 1, 2026 Read article
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Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile
Abstract: Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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Uttarabasti in Female Infertility: A Retrospective Analysis of Clinical Outcomes and Safety Profile
Abstract: Background: Uttarabasti (UB) is a specialized Panchakarma procedure involving intrauterine instillation of medicated Sneha, classically indicated in Yonivyapad and Vandhyatwa. It facilitates targeted local drug delivery, bypassing gastrointestinal metabolism and enabling direct therapeutic action at the uterine level. In Ayurvedic understanding, UB achieves Garbhashaya Shuddhi and Apana Vata Anulomana — the two primary pathological corrections considered essential in Vandhyatwa. Infertility affects an estimated 10–15% of couples globally, with a substantial …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 · pp. 1–14 Read article
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Therapeutic Evidence, Hazards and Patient Safety Precautions in Clinical Application of Electro-physical Agents
Abstract: The clinical utility of various electro-physical agents in physical therapy treatment care is known to offer placebo effects for patients for whom the physical agents have been found and suitable for therapeutic application. However, there are a few grey areas that need to be addressed in order to maximize the benefits derived from the use of these modalities. Though these electro-physical agents have direct benefits for the patients, the physiotherapist, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 1, 2018 · pp. 39–41 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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A Research Study and Report on Impact of Clinical Pharmacy on Vaccine Safety, Vaccine Vigilance, ADR Assesment and Reporting Among Pediatrics During Active Immunization Schedules at ESI Hospital
Abstract: Vaccine is a biological preparation that improves immunity to a given vaccine-preventable disease (VPD). A vaccine typically contains a disease-causing microorganism, or portion of it, and is often made from either live-attenuated or inactivated (killed) forms of the microbe, its toxin or one of its surface proteins. Vaccines may be monovalent or polyvalent (multivalent).. The main Aim of the study is to explore the knowledge, attitudes and concerns with respect …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 35–45 Read article
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A PROSPECTIVE STUDY ON HEMOVIGILANCE AND BLOOD TRANSFUSION SAFETY PRACTICES – IMPACT OF CLINICAL PHARMACIST.
Abstract: AIM & BACKGROUND:Blood Transfusions are lifesaving intervention but are associated withpotential to cause adverse events. The present study is conducted to track ATR’s patterns associated withblood and blood products and generate evidence-based recommendations and to promote optimal bloodusage.METHODS & MATERIALS: The present study is a prospective, observational and interventional studyconducted over a period of 10 months at ESI hospital, Indiranagar. About 90 patients undergoingtransfusions were selected for the study. Forms, …
Published in Trends in Drug Delivery · Vol. 9, Issue 3, 2022 · pp. 19–29 Read article
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RoseRAG-Based Clinical Decision Support System for Precision Medication Safety
Abstract: Medication-related errors remain a major challenge in healthcare, contributing to adverse drug events, increased hospitalization rates, and substantial healthcare costs. Conventional Clinical Decision Support Systems (CDSS) primarily rely on rule-based mechanisms for identifying drug-related problems (DRPs), including drug–drug interactions, contraindications, dosing errors, therapeutic duplication, and medication omissions. Although effective in structured environments, these systems frequently generate excessive context-insensitive alerts, leading to alert fatigue and reduced clinical acceptance. Recent developments in …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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A Practical Approach to Clinical Trials: Concepts and Methodologies
Abstract: AbstractClinical trial is a research study that is conducted on human volunteers to collect safety and efficacy data for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). Clinical trial is intended to produce knowledge valuable for understanding human disease, preventing and treating illness and promoting health. Clinical trials can only be conducted after gathering satisfactory information on the quality and non-clinical safety of the product, and after taking Ethics Committee …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 1, 2014 · pp. 35–40 Read article
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Role of Clinical Pharmacists During Cardiopulmonary Resuscitation in Intensive Care Units and Emergency Departments: A Narrative Review
Abstract: Cardiopulmonary resuscitation (CPR) represents an essential emergency procedure designed to reestablish spontaneous circulation and enhance survival rates among individuals suffering cardiac arrest. Successful resuscitation necessitates prompt clinical judgment, expeditious pharmaceutical interventions, compliance with advanced cardiovascular life support (ACLS) guidelines, and synchronized interprofessional collaboration. During recent decades, clinical pharmacists have gained greater incorporation within emergency response and resuscitation units owing to their specialized knowledge in medication oversight, pharmacotherapeutic enhancement, and patient …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 4, Issue 1, 2026 · pp. 12–25 Read article
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Safety of Ayurvedic Metal Origin Bhasma (Dhatu varga) through Acute Toxicity Studies: A Review
Abstract: Bhasma possess broad-spectrum therapeutic utility but are blamed due to frequently raising toxicity concerns. Although their safety has been evident with practice since ancient times, scientifically proven through toxicity studies, clinical safety, still comprehensive conclusive documentation is needed. Online published research articles on in vivo, oral single dose, acute toxicity studies on Bhasma of Dhatu Varga were searched through search engines and observations on behavioural, ponderal, autopsy, maximum tolerated dose …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 3, 2019 · pp. 43–50 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Formulating Pure Natural Polyherbal Hair Dye Preparation for Improved Coloring and Superior Protection Attributes as Compared to Marketed Products
Abstract: AbstractThe commercial synthetic hair dyes include permanent coloring agents like amino compounds (meta-aminophenol, 4-amino-2-hydroxytoluene, etc.), aromatic diamine, polycompounds (para-phenylenediamine), hydric phenols, etc. that precipitates several adverse effects like erythema, skin irritation, skin cancer, loss or damage of hair, etc. In the traditional systems of medicines like Unani, Ayurveda, Homeopathy, and Siddha, the recommended hair dyes are wholly based on plant materials (extracts) and metal oxides (iron oxide, titanium dioxide, etc.). …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 7, Issue 1, 2020 Read article
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Review article on Quality Control in Clinical Trials
Abstract: Quality control (QC) is a critical component in the conduct of clinical trials, ensuring the accuracy, reliability, and credibility of data collected throughout the study. It encompasses a systematic set of procedures designed to monitor trial conduct and data integrity, thus safeguarding the rights, safety, and well-being of participants. This review explores the principles, implementation, and evolving practices of quality control in clinical trials, highlighting its importance across all phases …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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A Comprehensive review on phytomedicinal activity of chirchita (Achyranthes aspera): an Indian Rural Medicinal Plant
Abstract: Because it is used to treat many types of diseases. Native to India, Achyranthes aspera (Chirchita) has been used in rural medicine for generations.This review explores the phytomedicinal significance of Achyranthes aspera, focusing on its bioactive compounds and the pharmacological activities that support its use in treating various ailments. This plant is a useful tool in traditional and alternative medicine. Because it has anti-inflammatory properties Antioxidants Antibacterial, anticancer and liver …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 74–85 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Path Lab-AI: An Autonomous Framework for Error-Free Histopathology Slide Interpretation
Abstract: Path Lab-AI represents a fully autonomous platform for the analysis of histopathology slides with circumscribed structures, designed to obtain highly accurate results using diagnostic methods and avoiding the usual limitations of standard microscopy-based pathology. Leveraging recent deep learning and whole slide image (WSI) analysis innovations, our system takes advantage of automated WSI ingestion along with pre-processing steps to account for staining variability, remove artifacts, and localize tissue from background. Such …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 19–30 Read article
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Simulation-Based Training in Nursing Education: An Academic Perspective
Abstract: Simulation-based education has become an important component of contemporary nursing education, providing students with opportunities to develop clinical competence, critical thinking, decision-making, and patient safety skills in a controlled learning environment. By recreating realistic clinical situations, simulation allows nursing students to apply theoretical knowledge, practice clinical procedures, and respond to patient care challenges without exposing actual patients to unnecessary risks. Different simulation approaches, including high- and low-fidelity manikins, standardized patients, …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 2, 2026 · pp. 42–47 Read article