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19 articles for “Antipsychotic drug.”
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Knowledge on Atypical Antipsychotic Drugs among Caregivers of Mentally Ill Patients
Abstract: Antipsychotic drugs have high rate of nonadherence due to unpleasant side effects. This study aimed to assess the caregivers’ knowledge on atypical antipsychotic drugs. A descriptive survey approach was used. The study was conducted among 100 caregivers of mentally ill patients receiving atypical antipsychotic drugs. The data were collected through a self-administered knowledge questionnaire on atypical antipsychotic drugs. The data were analyzed by using descriptive and inferential statistics. Results showed …
Published in Journal of Nursing Science & Practice · Vol. 5, Issue 3, 2015 · pp. 36–40 Read article
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Efficacy of Kalyanaka Ghritam and Sarpagandhadi yoga in Management of Scizophrenia.
Abstract: Clinical trials have shown that antipsychotic drugs alone have limited longterm efficacy. Moreover, they often have adverse side effects including dependency, drowsiness, impaired cognition and memory and sexual dysfunction. The present study was aimed at setting up a standard profile of Kalyanaka Ghrita and Sarpagandhadi yoga which was prepared using pharmacognostically authenticated raw drugs followed by subjecting it to detailed pharmacognostical analysis as per standard protocol.
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 1, 2022 · pp. 16–26 Read article
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Risperidone: A Silver Lining In Mental Disorders
Abstract: Risperidone (RYKINDO®) is second generation benzisothiazole which elevates linkage to serotonin type 2 (5HT2A) and dopamine type 2(D2) receptor developed by Luye Pharma Group used in short term palliative treatment of aggression or psychopathic disorders. Both 5HT2 antagonism with D2 receptor, it selectively bind to 5HT2A antagonist and shows neuroleptic effect by Risperidone. It is also available in the form of oral solution and disintegrating tablet etc. It is long …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 3, 2023 · pp. 11–21 Read article
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Analysis of Anti-psychotic Drug Penfluridol in Human Plasma by HPLC and MS/MS
Abstract: Penfluridol is a new long-acting neuroleptic drug known to be used widely for treating psychotic conditions. An internal standard was employed, which was penfluridol D7 (IS). The analyte and the IS were separated on a Phenomenex Kinetex C18, 5µm 100A, 100*4.6mm column using acetonitrile (40:60, v/v) as the mobile phase and 5 mM ammonium formate as the stationary phase. The retention time of Penfluridol and Penfluridol d7 was set at …
Published in Trends in Drug Delivery · Vol. 9, Issue 2, 2022 · pp. 36–45 Read article
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HPLC and Tandem MS Device for the Recognition of Emtricitabine and Tenofovir Alafenamide in K2EDTA Human Plasma Utilizing Emtricitabine 15ND2 Tenofovir D5 as an IS
Abstract: Developed very impressionable, discriminating, and exact extreme-efficiency liquid chromatographytandem bulk spectrometry form for measurement of Emtricitabine and Tenofovir Alafenamide in human plasma. Emtricitabine15ND2 Tenofovir D5 was used as a within the standard (IS). The samples were divided on Phenomenex Kinetex C18 5 μm 100A, 100*4.6 mm procession utilizing Acetonitrile: 0.2% formic acid, 60:40 V/V as movable state, the retention period of Emtricitabine: 1.36 minutes (±0.5 minutes), Emtricitabine 15ND2: 1.36 minutes …
Published in Research and Reviews: A Journal of Toxicology Read article
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In- silico Design of Novel Inhibitors for 5-HT2A Receptor to Recuperate Schizophrenia
Abstract: Schizophrenia is a mental disorder characterized by positive symptoms such as disorganized speech, delusions and hallucinations and negative symptoms such as deficits of attention, affective flattening and social withdrawal in nature. There are several receptor involve in schizophrenia, one of these 5-HT2A receptor i.e. serotonin receptor. The serotonin receptor 5-HT2A has been involved in several neurological conditions and potent 5-HT2A inhibitors have therapeutic effects that use for the treatment of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 11–17 Read article
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Assessment of “Patient’s Attitude†towards the Use of Antipsychotic Medications among Schizophrenia and BPAD Patients: Impact of Patient Counselling in Improving Their Attitude
Abstract: Aim of this paper is to assess the “patient’s attitude” towards the use of antipsychotic drugs among schizophrenia and BPAD patients and evaluate the effect of patient counseling in improving their attitude. The study was conducted in Psychiatric inpatient and outpatient department units of Rajiv Gandhi Institute of Medical Sciences (RIMS) of Kadapa in Andhra Pradesh in South India from December 2013 to May 2014. Patients diagnosed with schizophrenia or …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 2, 2015 · pp. 1–8 Read article
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Psychiatry During Pregnancy
Abstract: Psychiatric during pregnancy is increasingly recognized that many women with psychotic disorders have children and that pregnancies of these women are high-risk. Psychotic disorders increase the risk of stillbirth and infant mortality and can affect a woman’s ability to care for herself and her infant. Although women with psychoses are less fertile than the general population, partly as a result of hyperprolactinaemia secondary to antipsychotic drugs, the increasing use of …
Published in Journal of Nursing Science & Practice · Vol. 5, Issue 1, 2015 · pp. 53–57 Read article
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Herbal Medicine in Unani Tradition: Managing Depression from A Holistic Perspective
Abstract: Depression is a prevalent mental health condition marked by persistent sadness and a loss of interest in once- enjoyed activities, often accompanied by an inability to carry out daily tasks, lasting for at least two weeks. In the field of Unani medicine, this disorder falls under the category of "Nafsiyati awamil," with its classical description referred to as "Malenkholiya" or melancholia. According to the World Health Organization (WHO), depression ranks …
Published in Research & Reviews : Journal of Herbal Science · Vol. 12, Issue 3, 2023 · pp. 1–6 Read article
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Role of Neuropeptides in the Treatment of Major Depression Disorder: The Recent Updates
Abstract: Revelation of the part of neuropeptides as signaling atoms within the nervous system raised trust within the pharmaceutical field approximately 25. long time back Many neuropeptides, especially CRH, AVP, and substance P . whose receptors are presently focused on by little atoms to diminish side effects of discouragement and uneasiness, shows up to be related to the improvement and movement of temperament disarranges trouble. Neurotrophins, not exactly neuropeptides, may also …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 1–12 Read article
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Sexual Dysfunction Among Male Schizophrenics: A Comparison Between Psychotropic Medicines Treated and Treatment Naïve Patients
Abstract: Introduction: The prevalence of sexual dysfunction (SD) is higher in persons with mental disorders, particularly those treated with psychotropic medication. There are very few studies, especially in the Indian population, addressing the frequency of SD due to psychotropic medications. SD in schizophrenia may be a consequence of many factors; the condition itself, its socioeconomic impact and its treatment. Method: This cross-sectional study was conducted in the psychiatric unit of a …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 24–30 Read article
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Electroconvulsive Therapy in the Management of Schizophrenia: A Systematic Review in Emergency Nursing Practice
Abstract: Electroconvulsive therapy (ECT) is a well-established treatment for various psychiatric disorders, including schizophrenia, particularly in cases where patients are resistant to conventional treatments. Schizophrenia, a chronic and severe psychiatric disorder, often presents with a combination of positive symptoms (such as hallucinations and delusions), negative symptoms (such as social withdrawal and emotional blunting), and cognitive impairments. While antipsychotic medications are the primary treatment, approximately 20–30% of individuals with schizophrenia do not …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 43–48 Read article
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CBD: Wonder Drug of the Future
Abstract: The traditional “wonder drug” in pharmacology is aspirin, well known for its properties of pain control, lowering elevated body temperature, fighting inflammation, and decreasing blood coagulation. Aspirin, as a non-steroidal anti-inflammatory drug (NSAID) is a preventative drug as well as a therapeutic one. The Framingham heart study has concluded that a low dose aspirin regimen (81 mg/day) will help prevent cardiovascular disease and stroke. On the other hand, CBD (cannabidiol) …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 1, 2017 · pp. 1–5 Read article
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Application of Drug Delivery using Nano- technology to Cure Mental Disorders (Schizophrenia)
Abstract: Nanotechnology involves the manipulation of the count at an atomic scale to create novel systems, materials, and devices. This groundbreaking era holds substantial potential for scientific development across various domain names, which includes manufacturing, patron items, electricity, substances, and remedies. In current times, the sphere of prescribed drugs has witnessed a brilliant surge in the usage of nanotechnology for the improvement of revolutionary medications. Schizophrenia, a neuropsychiatric disorder affecting the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 51–65 Read article
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A Review on: Cotard’s Syndrome
Abstract: Cotard’s Syndrome is a rare and severe mental health condition characterized by nihilistic delusions, in which individuals firmly believe that they are dead, no longer exist, or that parts of their body are decaying or missing. These beliefs are not symbolic or metaphorical but are experienced as absolute truths, making the disorder particularly distressing and difficult to manage. The syndrome is most commonly observed in association with major depressive disorder, …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 5–9 Read article
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Application of Medicinal Plants to Cure Mental Disorders
Abstract: Mental fitness is a state of well-being in which individuals apprehend their talents, manage existing pressures, remain efficient, and contribute to their groups. Mental contamination regularly used interchangeably with intellectual illness, is vital to apprehending and addressing man or woman desires and challenges. Schizophrenia, a psychological disorder characterized by hallucinations and delusions, is a complex situation with two important classes: bad symptoms (withdrawal from social interactions, loss of force, and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 69–78 Read article
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Exploring Psychotropic Trends of Medication Use in Psychiatric Outpatients: An Observational Study at a Tertiary Care Hospital
Abstract: Background: Psychotropic medications are essential in managing a wide range of psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. Prescribing habits in outpatient clinics can differ a lot depending on things like the patient’s age, background, and medical conditions. Aim: This study aims to explore the trends in psychotropic medication use among psychiatric outpatients at a tertiary care hospital, with a focus on understanding prescribing patterns, demographic factors, and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 15–23 Read article
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Assessment of Psychomotor Performance of Under-therapy Patients Suffering from Schizophrenia with Healthy Volunteers
Abstract: Patients suffering from psychiatric disorders like schizophrenia and depression usually exhibit impaired psychomotor performance. Drug therapy can also affect their psychomotor performance. Therefore, present study was conducted to assess the psychomotor performance of such cases so that if there is any impairment, it can be detected, using battery of psychometric tests. In the present study, 20 schizophrenia patients taking drug therapy for not less than six months were compared with …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 1, 2013 · pp. 8–11 Read article