Research and Reviews : A Journal of Biotechnology Review Article
Application of Medicinal Plants to Cure Mental Disorders
Abstract
Mental fitness is a state of well-being in which individuals apprehend their talents, manage existing pressures, remain efficient, and contribute to their groups. Mental contamination regularly used interchangeably with intellectual illness, is vital to apprehending and addressing man or woman desires and challenges. Schizophrenia, a psychological disorder characterized by hallucinations and delusions, is a complex situation with two important classes: bad symptoms (withdrawal from social interactions, loss of force, and unresponsive emotional country) and high-quality signs and symptoms (hallucinations, delusions, and disordered thoughts). India has a large and diversified population, which contributes to a significant mental health burden that needs immediate treatment. Mental health illnesses affect people from all walks of life and transcend age, financial status, and geographic location. These disorders have a wide range of consequences, including increased society expenses, diminished everyday functioning, and personal misery. The increasing public health concern is a result of the steady growth in the prevalence of mental health diseases in India in recent years. It is estimated that around 15% of Indians suffer from mental health problems. Numerous conditions are included in this figure, such as substance use disorders, anxiety disorders, depression, bipolar disorder, schizophrenia, and neurodevelopmental disorders. Medicinal plants have vast potential in healthcare worldwide, mainly in growing international locations where 70-80% of people depend on traditional medication for primary healthcare wishes. These flowers of er a desire for novel remedies for drug-resistant diseases and ailments left unaddressed by mainstream prescription medications. Traditional healers have used several plant lives with validated healing blessings, consisting of natural remedies incorporated into psychiatry for intellectual ailments like schizophrenia. Phytochemicals determined in vegetation can enhance the features of diverse human organs, preventing many diseases. Many traditional medicinal herbs and their components have healing properties and may be used to save you, deal with, or cure diverse human sicknesses.
Keywords
References (54)
- Aljunaidy MM, Adi MN. Architecture and Mental Disorders: A Systematic Study of Peer-Reviewed Literature. HERD: Health Environments Research & Design Journal. 2020;14(3):320-330. doi:10.1177/1937586720973767
- Hernández-Torrano D, Ibrayeva L, Sparks J, Lim N, Clementi A, Almukhambetova A, et al. Mental Health and Well-Being of University Students: A Bibliometric Mapping of the Literature. Frontiers in Psychology. 2020;11. doi:10.3389/fpsyg.2020.01226
- World Health Organization (WHO). Depression and other common mental disorders: Global health estimates. 2022.
- Allen NB. Book Review: Cognitive Therapy of Depression. Australian & New Zealand Journal of Psychiatry. 2002;36(2):275-278. doi:10.1046/j.1440-1614.2002.t01-5-01015.x
- Ellsworth PD. Diagnostic and statistical manual of mental disorder. Am J Occup Ther. 1980;34(12):819. doi:10.5014/ajot.34.12.819a.
- Belmaker RH, Agam G. Major Depressive Disorder. New England Journal of Medicine. 2008;358(1):55-68. doi:10.1056/nejmra073096
- Eylem O, de Wit L, van Straten A, Steubl L, Melissourgaki Z, Danışman GT, et al. Stigma for common mental disorders in racial minorities and majorities a systematic review and meta-analysis. BMC Public Health. 2020;20(1). doi:10.1186/s12889-020-08964-3
- Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomedicine. 2006;13(9-10):607-611. doi:10.1016/j.phymed.2006.08.006
- Akhondzadeh S, Tahmacebi‐Pour N, Noorbala AA, Amini H, Fallah‐Pour H, Jamshidi AH, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double‐blind, randomized and placebo‐controlled trial. Phytotherapy Research. 2005;19(2):148-151. doi:10.1002/ptr.1647
- Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007;31(2):439-442. doi:10.1016/j.pnpbp.2006.11.010
- Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]. BMC Complementary and Alternative Medicine. 2004;4(1). doi:10.1186/1472-6882-4-12
- Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. Journal of Ethnopharmacology. 2005;97(2):281-284. doi:10.1016/j.jep.2004.11.004
- Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Journal of Integrative Medicine. 2013;11(6):377-383. doi:10.3736/jintegrmed2013056
- Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Human Psychopharmacology: Clinical and Experimental. 2014;29(6):517-527. doi:10.1002/hup.2434
- Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, et al. A double-blind, randomized and placebo-controlled trial of Saffron ( Crocus sativus L.) in the treatment of anxiety and depression. Journal of Complementary and Integrative Medicine. 2016;13(2):195-199. doi:10.1515/jcim-2015-0043
- Teschke R, Gaus W, Loew D. Kava extracts: Safety and risks including rare hepatotoxicity. Phytomedicine. 2003;10(5):440-446. doi:10.1078/0944-7113-00314
- Pantano F, Tittarelli R, Mannocchi G, Zaami S, Ricci S, Giorgetti R, et al. Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat. International Journal of Molecular Sciences. 2016;17(4):580. doi:10.3390/ijms17040580
- Abolhassani M. Clinical research Antiviral activity of borage ( Echium amoenum ). Archives of Medical Science. 2010;3:366-369. doi:10.5114/aoms.2010.14256
- Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2006;30(1):166-169. doi:10.1016/j.pnpbp.2005.10.005
- Deepak K, Suresh K. Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts. Indian Journal of Pharmaceutical Education and Research. 2015;49(1):66-70. doi:10.5530/ijper.49.1.9
- Anita R, Chander M. Pharmacological and Phytochemical Evaluation of Calendula officinalis Linn. For Anti-Anxiety Activity. International Journal of Pharmacognosy and Phytochemical Research. 2017;9(1). doi:10.25258/ijpapr.v9i1.8051
- Kaur D, Shri R, Kamboj A. Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals. Pharmacognosy Journal. 2017;9(5):638-643. doi:10.5530/pj.2017.5.101
- World Health Organization (WHO). Schizophrenia. 2022. https://www.who.int/news-room/fact-sheets/detail/schizophrenia#:~:text=Schizophrenia%20affects%20approximately%2024%20million,as%20many%20other%20mental%20disorders.
- Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, et al. Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016. Schizophrenia Bulletin. 2018;44(6):1195-1203. doi:10.1093/schbul/sby058
- Rajendran R, Menon KN, Nair SC. Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia. Advanced Pharmaceutical Bulletin. 2021;12(3):490-508. doi:10.34172/apb.2022.052
- Rathbone J, Zhang L, Zhang M, Xia J, Liu X, Yang Y. Chinese herbal medicine for schizophrenia. Cochrane Database of Systematic Reviews. 2005;2013(2). doi:10.1002/14651858.cd003444.pub2
- Xiao S, Han X, Li X, Chen C, Li G, Yuan C, et al. A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia. Neurosci Bull. 2011;27(4):258-268. doi:10.1007/s12264-011
- Deng H, Adams CE. Traditional Chinese medicine for schizophrenia: A survey of randomized trials. Asia-Pacific Psychiatry. 2016;9(1). doi:10.1111/appy.12265
- Shorvon SD. The causes of epilepsy: Changing concepts of etiology of epilepsy over the past 150 years. Epilepsia. 2011;52(6):1033-1044. doi:10.1111/j.1528-1167.2011.03051.x
- Wa H. Epilepsy: frequency, causes and consequences. CiNii Res. 1990. https://cir.nii.ac.jp/crid/1572543024619962880.
- Stafstrom CE, Carmant L. Seizures and Epilepsy: An Overview for Neuroscientists. Cold Spring Harbor Perspectives in Medicine. 2015;5(6):a022426-a022426. doi:10.1101/cshperspect.a022426
- Pahuja M, Mehla J, Reeta KH, Joshi S, Gupta YK. Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. Epilepsy & Behavior. 2011;21(4):356-363. doi:10.1016/j.yebeh.2011.05.013
- Pahuja M, Kleekal T, Reeta KH, Tripathi M, Gupta YK. Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock‐induced seizures in rats. Epilepsy & Behavior. 2012;25(3):368-373. doi:10.1016/j.yebeh.2012.08.014
- Ahmad B. Distribution, morphology, and medicinal uses of Taxus baccata. DeptOZ. 1997. https://agris.fao.org/search/en/providers/122650/records/6472305f53aa8c896301d8a5.
- Nisar M, Khan I, Simjee SU, Gilani AH, Obaidullah, Perveen H. Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc. Journal of Ethnopharmacology. 2008;116(3):490-494. doi:10.1016/j.jep.2007.12.021
- Wang SQ, Li XJ, Zhou S, Sun DX, Wang H, Cheng PF, et al. Intervention Effects of Ganoderma Lucidum Spores on Epileptiform Discharge Hippocampal Neurons and Expression of Neurotrophin-4 and N-Cadherin. PLoS ONE. 2013;8(4):e61687. doi:10.1371/journal.pone.0061687
- Socala K, Nieoczym D, Grzywnowicz K, Stefaniuk D, Wlaz P. Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice. International Journal of Medicinal Mushrooms. 2015;17(3):209-218. doi:10.1615/intjmedmushrooms.v17.i3.10
- Tello I, Campos-Pena V, Montiel E, Rodriguez V, Aguirre-Moreno A, Leon-Rivera I, et al. Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes). International Journal of Medicinal Mushrooms. 2013;15(6):555-568. doi:10.1615/intjmedmushr.v15.i6.40
- Wang SQ, Li XJ, Qiu HB, Jiang ZM, Simon M, Ma XR, et al. Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII α in Epileptic Hippocampal Neurons. PLoS ONE. 2014;9(7):e102161. doi:10.1371/journal.pone.0102161
- MacLaren R, Forrest LK, Kiser TH. Adjunctive Dexmedetomidine Therapy in the Intensive Care Unit: A Retrospective Assessment of Impact on Sedative and Analgesic Requirements, Levels of Sedation and Analgesia, and Ventilatory and Hemodynamic Parameters. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2007;27(3):351-359. doi:10.1592/phco.27.3.351
- Zakrzewska JM, McMillan R. Trigeminal neuralgia: the diagnosis and management of this excruciating and poorly understood facial pain. Postgraduate Medical Journal. 2011;87(1028):410-416. doi:10.1136/pgmj.2009.080473
- Cruccu G, Gronseth G, Alksne J, Argoff C, Brainin M, Burchiel K, et al. AAN‐EFNS guidelines on trigeminal neuralgia management. European Journal of Neurology. 2008;15(10):1013-1028. doi:10.1111/j.1468-1331.2008.02185.x
- Ho KY, Emril. Treatment of trigeminal neuralgia: role of radiofrequency ablation. Journal of Pain Research. 2010:249. doi:10.2147/jpr.s14455
- Pollock BE. Surgical Management of Medically Refractory Trigeminal Neuralgia. Current Neurology and Neuroscience Reports. 2011;12(2):125-131. doi:10.1007/s11910-011-0242-7
- Muthuraman A, Singh N, Jaggi AS. Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats. Journal of Natural Medicines. 2010;65(2):282-292. doi:10.1007/s11418-010-0486-6
- Watcho P, Stavniichuk R, Ribnicky DM, Raskin I, Obrosova IG. High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract ofArtemisia dracunculusL. Mediators of Inflammation. 2010;2010:1-10. doi:10.1155/2010/268547
- Hong JH, Lee IS. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chemico-Biological Interactions. 2009;179(2-3):88-93. doi:10.1016/j.cbi.2008.12.002
- Mohammad Reza S, Hamideh M, Zahra S. The Nociceptive and Anti-Inflammatory Effects ofArtemisia dracunculusL. Aqueous Extract on Fructose Fed Male Rats. Evidence-Based Complementary and Alternative Medicine. 2015;2015:1-5. doi:10.1155/2015/895417
- Thiagarajan VRK, Shanmugam P, Krishnan UM, Muthuraman A, Singh N. Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. Toxicology and Industrial Health. 2012;29(1):3-13. doi:10.1177/0748233711432573
- Thiagarajan VRK, Shanmugam P, Krishnan UM, Muthuraman A, Singh N. Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. Anais da Academia Brasileira de Ciências. 2012;84(4):1091-1104. doi:10.1590/s0001-37652012005000063
- Zhou J, Ouedraogo M, Qu F, Duez P. Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview. Phytotherapy Research. 2013;27(12):1745-1755. doi:10.1002/ptr.4942
- Rodrigues E, Barnes J. Pharmacovigilance of Herbal Medicines. Drug Safety. 2012;36(1):1-12. doi:10.1007/s40264-012-0005-7
- Farah MH, Edwards IR, Lindquist M, Shaw D. International monitoring of adverse health effects associated with herbal medicines. Pharmacoepidemiol Drug Saf. 2000;9(2):105-12. doi:10.1002/(sici)1099-1557(200003/04)9:
- Chaudhari V, Pinjari P, Patil P, Khandare S, Salunke R. Future prospects of medicinal plants. Int J Pharm Res Appl. 2022;7(3):1816-22.