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113 articles for “Animal models”
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An Insight to Animal Models of Drug Induced Schizophrenia
Abstract: Schizophrenia is a mental disorder that generally shows in early adulthood or late adolescence characterized by hallucinations, delusions, and other cognitive dysfunctions, schizophrenia can often be a lifelong problem. Schizophrenia affects approx. 1% of all adults, universally. The purpose of this article is to review several drug induced schizophrenia animal models. The scientific study of human disorders has required the development of suitable animal models. The prevailing recent view of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 21–33 Read article
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A Review on Wound Healing: Pathophysiology, Animal Model and Role of Biomarkers
Abstract: AbstractBlood cells, extracellular matrix, parenchyma cells, and soluble mediators are all involved in the physiological process of wound healing, which is highly complex, dynamic, interactive, and well-regulated. The 4 stages of wound healing are separated out. Hemostasis b. Inflammation c. Proliferation d. Remodeling. Many animal models are employed in the examination of wound healing activities because a large variety of models have been produced for examining different components of the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 29–39 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Anti-Depressant Activity of Aqueous Leaf Extract of Pergularia daemia in In-Vivo Animal Models
Abstract: The plant leaf of Pergulariadaemia was used for management of depressive state in various traditional system of medicine like Ayurveda, Unani and Siddha. In the absence of substantial pharmacological data, the present study attempts to study the antidepressant activity of Pergulariademia aqueous extract, by using forced swim test and tail suspension test. Animals were grouped into four treatment groups (n=4) and injected with normal saline (control), imipramine-10 mg/kg (Standard drug), …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 5, Issue 3, 2015 · pp. 21–26 Read article
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Toxicological and Pharmacological Effect of Khadirarista in Animal Model
Abstract: AbstractThe objective of this study is to investigate the toxicological and pharmacological aspects of the popular Ayurvedic preparation Khadirarista (KDR). Khadirarista was administered orally to male albino rat. After 46 days of treatment period, animals were fasted for 18 h after the last administration. Biochemical studies including; total protein, serum albumin, blood urea nitrogen, bilirubin, creatinine, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were conducted. Triglyceride and creatinine levels were …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2013 · pp. 61–67 Read article
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Acute and Chronic Toxicity of Fluoride and Aluminum on Plant and Animal Models
Abstract: Ecotoxicological studies revealed aluminum (Al2SO4. 24 H2O) to be more toxic than fluoride (NaF) on a battery of test organisms (EC/LC50 of Al = 0.308 1.46 ppm; F = 116.6 232.8 ppm). During chronic exposure (Al = 3 ppm, F = 10 ppm for 60 90 days), there was reduction in growth parameters of organisms at different trophic levels in a food chain such as producers {dry weights (6.7 29.0) …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 1–19 Read article
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A Study of DCGAN-Based Generative Models for Anime Character Face Generation
Abstract: Artificial intelligence, or AI, has in recent years moved from simple rule-based systems to models that are now fully capable of creative content generation and are referred to as generative AI. One such approach for content generation, introduced in the year 2014, is called generative adversarial networks (GANs), which consists of training a generator to create fake content that tries to mimic real content as closely as possible and a …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 13, Issue 1, 2026 · pp. 31–41 Read article
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Designer Zinc Finger Nuclease: A Versatile Tool for Genome Editing in Animals
Abstract: In this review, is provided an update on the most popular approaches, including zinc finger nuclease (ZFN)-based gene editing by homologous recombination (HR), gene knockout, non-homologous end joining (NHEJ), and gene therapy in mouse. Zinc finger nucleases (ZFNs) are synthetic restriction enzymes evolved by fusing zinc finger that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location. ZFNs are new tools that promise to radically …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 4, Issue 1, 2014 · pp. 24–30 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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Development of High Sugar Induced Hyperglycemia or Type 2 Diabetes in Zebrafish (Danio rerio) Model
Abstract: Type 2 diabetes (T2D) is the most common form of diabetes, accounting for about 90–95% of all diagnosed cases of diabetes in adult. It is mainly recognized by an increase in blood glucose levels, i.e., hyperglycemia. Earlier, zebrafish (Danio rerio) has been already used for the study of various metabolic diseases. In the present study, a validation study was done for the earlier developed acute hyperglycemia zebrafish model by using …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 60–66 Read article
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Synthesis and Evaluation of New Coumarin Derivatives for Inflammatory Bowel Disease Against DSS-Induced Acute Ulcerative Colitis Mice Model
Abstract: Objective: The discovery of the now numerous mouse models of intestinal inflammation has increased our understanding of the intestinal inflammation that occurs in inflammatory bowel disorders (IBD). This study aimed to investigate the use of a standardized animal model subjected to coumarin derivative treatment, and the action of synthesized molecule administration of dextran sodium sulphate (DSS)- induced colitis in experimental mice. Materials and Methods: We generated a variety of unique …
Published in Journal of Modern Chemistry & Chemical Technology Read article
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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Laboratory Animals: Usages in Genetic Research
Abstract: Laboratory animals are one on which advanced research is conducted and validated in labs for better understanding the natural phenomenon of biological system, genetics and disease models. Laboratory animals include mice, rat, hamster, guinea pig, gerbil, monkey etc. Lab animals play a vital role in biomedical research and genetic studies as they share common physiology and genetics, which resemble to a large extent with humans and thus make them excellent …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 7, Issue 1, 2017 · pp. 14–21 Read article
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Enhancing Wildlife Tourism Management Using Deep Learning and Particle Swarm Optimization (PSO) for Animal Detection in Wildlife Sanctuaries
Abstract: Wildlife tourism is one of the most thriving sectors, faced with huge challenges in terms of safeguarding protected areas. As demand for wildlife experiences accelerates, it becomes necessary to find efficient measures that are friendly to conservation. The use of these advanced techniques in this field such as YOLO and PSO algorithm presents a new dimension on managing wildlife tourism. To harness the abilities of these techniques, this research centers …
Published in Current Trends in Signal Processing · Vol. 14, Issue 3, 2024 · pp. 41–50 Read article
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Pharmacokinetic Study of Iron Absorption from Unani Compound Formulation in Animals
Abstract: Background: Iron is an indispensable element for survival and normal functioning of the human cells. It is required for a large number of biochemical reactions in the cells. It is a vital component of haemoglobin, myoglobin, cytochromes, catalases and many other enzyme systems like Krebs cycle. It is essential for oxygen transport and oxidation reactions in cells. Iron deficiency is the most prevalent deficiency disorders of human beings in the …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 10, Issue 1, 2023 · pp. 1–5 Read article
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The study on the isolation, culture, differentiation and transplantation of neural stem cells from brain of crossbred white rat in the neonatal period
Abstract: We have studied for isolating neural stem cells from brain tissue of neonatal crossbred white rat, culturing and transplanting into local cerebral ischemic reperfusion model rat. We performed digestion of brain tissue, primary culture and subculture of segregated cells, measured number of neurosphere and growth index and ratio of cell survival, and identified expression of nestine from cultured cells, investigated engraftment of NSCs into ill brain tissue after transplantation of …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 2, 2022 · pp. 13–19 Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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Zebra Fish Embryo Assay: A Wonderful Tool for Ecotoxicological Risk Assessment with Special Reference to Heavy Metals - An Overview
Abstract: In recent years, environmental pollution has become a pressing concern, prompting extensive research in aquatic ecotoxicology. With environmental degradation getting worse day by day, ecotoxicology research has gained a lot of attention. This area of study examines how biological communities in aquatic environments are affected by environmental contaminants. To unravel the toxicological mechanisms of these exogenous compounds, scientists turn to biological models. Several aquatic species, including zebrafish, toads, and big …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 56–70 Read article
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Computational Investigation of nsSNPs of PRSS1 Gene
Abstract: This research is done for the prioritizing of SNPs of a gene PRSS1 causing hereditary pancreatitis. In this analysis, the authors found out some nsSNPs as less stable, deleterious, probably damaging retain high risk score. It was also predicted that SIFT is fast SNPs server with comparison of PolyPhen2. By Doing its energy calculation and stability prediction, we can also determine the stability of mutant protein, that is ok whether …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 1, 2014 · pp. 15–22 Read article
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Protective Effect of Chloroform Extract of Cyperus Rotundus against DNBS Induced Inflammatory Bowel Disease in Rats
Abstract: The present study was designed to evaluate the effects of Cyperus rotundus on DNBS (Dinitrobenzene sulfonic acid) induced IBD in experimental rats. The experimental protocol (Protocol No. 9012 dated 26th Dec 2009) was approved by Institutional Animal Ethical Committee of Anand Pharmacy College. Colitis was induced with DNBS (180 mg/kg in 50% ethanol) intracolonically in animals on the 11th day of the study. Animals were fasted for 24 h prior …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 3, 2014 · pp. 24–32 Read article