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262 articles for “therapeutics”
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Evaluation of Antioxidant and Cytotoxic activities of Mycelia Biomass and Culture broth of three Edible Mushrooms, Morchella conica, Hericium erinaceus and Pleurotus florida Grown in Submerged Culture
Abstract: Mycelia biomass of three edible mushrooms namely, Morchella conica, Pleurotus florida and Hericium erinaceus were grown as submerged culture in potato dextrose broth supplemented with yeast extract, potassium dihydrogen orthophosphate and magnesium sulphate. The mycelia biomass was extracted with 70% ethanol and culture broth with ethyl acetate. The solvents were evaporated to dryness at low temperature using a rotary vacuum evaporator and the residues thus obtained were used for the …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 37–50 Read article
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Chemical Composition and Antimicrobial Efficacy of Ferula persica Extracts: A Phytochemical and Bioactivity Assessment in Iraq
Abstract: The research presented in the tables focuses on analyzing the chemical content of extracts from the Ferula persica plant, a wild species in Iraq with significant medical and therapeutic importance dating back to ancient times. This study involved testing some chemical and physical properties of the alcoholic extract of the plant's aerial parts and evaluating its antimicrobial activity, specifically against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 10–22 Read article
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Comprehensive Approaches to Understanding and Managing Alzheimer’s Disease
Abstract: Alzheimer’s disease is an advanced neurodegenerative disorder described by intense memory loss. It strictly affects the patient’s quality life. The popularity of AD has been increasing in recent years. It is the most common form of mental disorder affecting more than 20 million people in the world. The Alzheimer’s disease is treated with cholinesterase inhibitors or NMDA-receptor (N-methyl D-aspartate) antagonists but here the question is about the therapeutic effect of …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Psychotherapeutic Approaches for Enhancing Perinatal Mental Health
Abstract: Pregnancy is a life turning event in a woman's life. Many women during pregnancy and after the birth of the child face mental health issues like anxiety, depression, and stress due to varied reasons. If not addressed properly, these can affect the mother-child bond, the lady's relationship with the entire family, and the child's cognitive and emotional development. As per WHO, “Globally about 10% of pregnant women and 13% of …
Published in International Journal of Behavioral Sciences · Vol. 1, Issue 2, 2024 · pp. 26–38 Read article
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Extended Spectrum Beta-Lactamase Production By Acinetobacter baumannii Isolated From Hospital Environment
Abstract: Extended spectrum β-lactamases production was determined by Double Disc synergy test for twenty one bacterial isolates of Acinetobacter bumannii isolated from the hospital environment. This study investigates the prevalence, genetic mechanisms, and clinical implications of ESBL production by A. baumannii. We employed molecular techniques to identify and characterize ESBL genes in clinical isolates, alongside evaluating their susceptibility profiles against a range of antibiotics. These resistant strains were notably associated with …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 71–78 Read article
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Rauwolfia Serpentina: A Comprehensive Phytochemical Study of Its Bioactive Metabolites
Abstract: Rauwolfia Serpentina is an important medicinal plant used in Ayurveda, Unani, and folk medicine system of medicine. This plant grew as a bush in company of other plants as an evergreen structure. It is commonly known as ‘Sarpaghanda’. in Ayurvedic and Unani medicine system. It is safe and effective for the treatment of snakebites and various types of disease like malaria, breast cancer, prostate cancer, high blood pressure, insomnia, epilepsy, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 25–50 Read article
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Artificial Intelligence Based Portable Robot Device for Autonomous Venepuncture
Abstract: Venepuncture is a source of medical hurt and is necessary for a wide range of therapeutic procedures. Venpuncture-related complications worsen in difficult settings, where the success rate is largely dependent on the physiology of the patient and the skill of the practitioner. It is difficult to find the vein for infants, adolescent girls, obese and elderly people and it is causing severe pain in the traditional manual blood drawing system. …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 2, Issue 1, 2024 · pp. 35–38 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Butrin Tackles Retinoblastoma – A Clinical Hypothesis †
Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Comparative Analysis of Bioactive Phytochemical Profiles of Moringa Oleifera and Aegle Marmelos Grown in Bundelkhand
Abstract: A comparative analysis of the bioactive phytochemical profiles of Moringa oleifera and Aegle marmelos grown in the Bundelkhand region was conducted to explore their potential health benefits. These properties make healing plants valuable in herbal medicine, supporting various aspects of health and well-being. The study aimed to determine the differences in the concentrations of bioactive compounds such as phenolic, flavonoids, alkaloids, and vitamins C and E in the leaves and …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 14–24 Read article
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An Insilico Study of Isobutrin and Phosphorylase Kinase - A Ray of Hope for Psoriasis Patients – Clinical Hypothesis
Abstract: Psoriasis is a chronic, hyper-proliferative and inflammatory skin disease. Increased levels of the calmodulin-containing enzyme, namely, phosphorylase kinase (PhK), were observed in the human epidermis of the active psoriasis cases. Thus PhK is a potential biomarker for the diagnosis and progression of the skin disease, namely, psoriasis. The search for the potential molecules that could supress the over expression of PhK is underway and any break-through in this direction leads …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article
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Advances in Polymeric In Situ Drug Delivery and Soft Biosensors: Innovations in Biochemical Sensing and Personalized Healthcare
Abstract: Advanced healthcare and personalized medicine are undergoing a transformation thanks to in situ medication delivery systems and biochemical sensor technology. Polymeric in situ drug delivery systems form gels upon administration, releasing medications in a controlled manner and providing benefits such as ease of administration and enhanced patient compliance. Similarly, advancements in soft electronics, including flexible and stretchable biosensors, enable continuous, in situ biochemical monitoring, conforming to complex biological environments like …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 27–32 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article