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311 articles for “Metabolism”
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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Herbal Drug Used in the Treatment of Diabetes: A Review
Abstract: Background: Diabetes mellitus is a chronic disease that occurs at the point when the pancreas is not able to produce insulin, or when the body cannot utilize the insulin it produces. Diabetes mellitus is a complex metabolic disorder that affects various systems of body such as visual, circulatory, renal and nervous system. Human beings depend upon plants for their various needs such as food, fodder, fuel, timber, fibres, dyes, gums, …
Published in Research & Reviews : Journal of Herbal Science Read article
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The Role of Cholesterol in Biological Membranes
Abstract: Cholesterol plays the role of a regulator that ensures the correct packaging of the lipid part of the membrane, which is necessary for its normal operation, by influencing on the mobility of the fatty acid tails of membrane lipids: if the membrane is too rigid and there is a danger of "freezing" of fatty acid chains, cholesterol causes it to liquefy, since the chains in its presence become more mobile; …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 Read article
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To evaluate the effectiveness of a structured educational program on knowledge about hypoglycemia and its management among diabetes patients living in selected urban slums of Durgapur, West Bengal
Abstract: INTRODUCTION: Diabetes Mellitus (DM) is a significant global health issue characterized by chronic hypoglycemia and an imbalance in the metabolism of carbohydrates, fats, and proteins. It has multiple underlying causes. Hyperglycemia refers to high blood glucose levels, while low blood glucose levels are known as hypoglycemia. Raising awareness about the signs and symptoms of diabetes among individuals with the condition can potentially minimize complications. OBJECTIVES: 1. To evaluate the initial …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Effect of Energy, Lysine and Energy/Lysine Ratio on Growth Performance Nutrient Digestibility and Serum Profile of Growing Locally Adapted Turkey
Abstract: This study investigated the effects of different levels of energy, lysine and energy/lysine ratios on growth performance, nutrient digestibility, and serum biochemical indices of locally adapted turkeys. The experiment lasted for 28 days. A total of one hundred and forty-four, 4-weeks old locally adapted turkey poults were completely randomized to six dietary treatments in a 2×3 factorial arrangement, replicated twice at 12 poults per replicate. Six diets were formulated. Diets …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 01–08 Read article
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Bioactive Compounds in Ethanolic Extract of Strychnos innocua Root Using Gas Chromatography and Mass Spectrometry (GC-MS)
Abstract: Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids and saponins) which can discharge numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cytotoxic, antipyretic, antitumor, antihelminthic, antiprotozoal, antibacterial, and so on). The use of gas chromatography and mass spectrometry analysis in identifying the bioactive compounds in the ethanolic …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 9–14 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Rheumatoid Arthritis and its Relationship with Vitamin D, ESR, and Obesity
Abstract: Recent years have seen a rise in the prevalence of rheumatoid arthritis (RA), a disease marked by the destruction of articular cartilage and ankylosis of the joints, as well as other complications such as diffuse lung inflammation, sclera, pleura, pericardium, and nodular lesions, which are also common in subcutaneous tissue. Reviewing RA symptoms, diagnosis, treatment, and associations with vitamin D, ESR, and obesity was the aim of the study. Even …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 06–12 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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Harnessing the Medicinal Potential of SwertiaChirata: A Phytochemical Strategy for Controlling Coronavirus Symptoms Like High Fever and Anxiety
Abstract: The current investigation focuses on exploring the therapeutic capacities of SwertiaChirata, colloquially known as Chirata, in managing the symptomatic displays of coronavirus infections. Chirata, a member of the Gentianaceae family, is a distinguished herb extensively used in Ayurvedic and Unani medicinal traditions, acknowledged for its myriad of healing qualities. In addition to its regular use in combating fever and loss of appetite, its prominent antioxidant traits position it as an …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 27–31 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Phytase enzyme and its remarkable effects on chicken health
Abstract: Phytase enzyme catalyzes the hydrolysis of Phytate to mono, di, tri, tetra and penta Phosphate of Myoinositol and Inorganic Phosphate. Cereals, legumes and oilseeds are the main ingredients of animal feed. Phytic acid or phytate is the chief storage form of phosphorus in the feed obtained from these plant sources. Phytate bound important mineral, metal ions and amino acids with it, and in this way it is anti-nutritional element. Simple …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 37–41 Read article
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Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism
Abstract: One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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Diet Management of Cancer Patients Who Undergo Chemotherapy—An Experimental Study
Abstract: Background: Chemotherapy is the one major treatment module for cancer patients, but it has so many side effects, including nausea, vomiting, fatigue, and pain. These side effects reduce the adherence towards chemotherapy and reduce the interest to have foods. This, in turn, affects the normal tissue metabolism and disturbs the functions of cell and tissue regeneration. Food is very important for patients who receive chemotherapy. The cyclic administration of chemotherapy …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 1, 2024 · pp. 17–21 Read article
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Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke
Abstract: Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 19–31 Read article