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324 articles for “mechanical activation”
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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A Review on Loading Methodologies of Active Aromatic Substance into Biopolymers
Abstract: Biopolymer-based films are increasingly being studied as sustainable alternatives to conventional packaging materials due to their biodegradability, renewability, and potential for functionalization. There are several natural polymers in the category of biopolymers such as soy protein, zein, cellulose, chitosan, and several other biodegradable synthetic polymers such as polylactic acid and polycaprolactone. However, these often show limitations in barrier properties, mechanical strength, and resistance to microbial contamination. To overcome these drawbacks, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 9–13 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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Optimizing MEMS-Based Energy Harvesting with Piezoelectric and Thermoelectric Polymer Composites
Abstract: This research explores the development and performance of polymer-based composites, particularly Polyvinylidene Fluoride (PVDF) and Electro active Polymers (EAPs), in MEMS-based energy harvesting systems. PVDF, a flexible piezoelectric material, is combined with ceramic powders such as lead zirconatetitanate (PZT) to enhance its piezoelectric response while retaining mechanical flexibility. EAPs, including ionic polymer-metal composites (IPMCs) and dielectric elastomers, are investigated for their ability to generate electrical power from mechanical deformations, offering …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 221–237 Read article
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Material-Integrated Energy Management: Role of Advanced Polymers and Composites in Smart Homes
Abstract: The article discusses the possibility of improving the performance as well as the sustainability of smart-home-based energy management systems (EMS) by applying advanced polymeric and composite materials. Smart homes today are placing greater requirements on lightweight, thermally stable, high durability, and electrically conducting compounds in such important aspects of the devices as batteries, substrate layers in solar panels, thermally resistant enclosures, and high efficiency thermal insulation on intelligent appliances. Such …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1361–1374 Read article
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Design and Implementation of an IoT-Based Power Theft Detection System Using Sensor Networks
Abstract: With the increasing demand for efficient energy distribution and consumption monitoring in smart grid systems, the need for robust power theft detection mechanisms becomes paramount. This project proposes an IoT-based solution utilizing energy metering to detect instances of power theft within different segments of the distribution network. The system employs three types of energy meters: Distribution Point (DP), Pole, and Domestic meters. Every meter is positioned thoughtfully to track the …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 2, 2024 Read article
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Nuclear Reactor Safety Using Seismic and Natural Disaster Protection: A Study
Abstract: Nuclear energy has enormous power and is essential to the global effort to provide clean, sustainable electricity, but it also carries a huge responsibility: guaranteeing its complete safety. Nuclear energy is at a turning point. Nuclear power provides a potent, carbon-free answer as the globe struggles with climate change and the pressing need to decarbonize energy grids. However, public fear, primarily from past mishaps like Chernobyl and Fukushima, continues to …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 25–34 Read article
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Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
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Digital Agriculture Schemes in Kerala: Risk Analysis and Multi-Layered Security Framework
Abstract: Kerala’s agricultural sector is undergoing rapid digital transformation, driven by initiatives such as the e-Krishi platform and the growing adoption of Internet of Things (IoT)–enabled precision farming technologies. While these developments promise improved productivity, transparency, and data-driven decision-making, they also introduce significant cybersecurity and data governance challenges that cannot be overlooked. This paper critically examines the emerging security, privacy, and operational risks associated with the digitization of agricultural services in …
Published in Journal Of Network security · Vol. 14, Issue 1, 2026 · pp. 23–30 Read article
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Thermodynamic Irreversibility in Semen Transport
Abstract: Sperm ejaculation is a vital reproductive process that involves both complex biological functions and energetic mechanisms. Beyond the physiological aspects, thermodynamics offers a framework to analyze energy conversion, exergy use, and irreversibility during sperm activity. ATP provides the main source of exergy for motility, but part of this energy is inevitably lost as heat and entropy generation, reflecting inefficiencies in the process. Because heat regulation directly affects metabolic rates, motility …
Published in Journal of Thermal Engineering and Applications · Vol. 13, Issue 1, 2026 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Integrative Perspectives on Lipoma: Traditional Therapeutics from Siddha, Ayurveda, and Unani with Biomedical Correlates
Abstract: Background: Lipoma is the most common benign soft tissue tumor, with an incidence of approximately 2 per 1,000 individuals annually. Modern biomedicine attributes its pathogenesis to genetic abnormalities like HMGA2 rearrangements and dysregulated adipogenesis via PPARγ pathways. Effective pharmacological therapies are lacking. Traditional Indian systems – Siddha, Ayurveda, and Unani – offer unique perspectives and non‑surgical approaches yet remain underexplored in integrative research. Objective: To critically evaluate the descriptions, pathophysiological …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 19–33 Read article
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Solid-State Reactions: Mechanistic Insights, Kinetic Behavior and Emerging Applications in Advanced Materials
Abstract: Solid-state reactions are fundamental to the synthesis and transformation of inorganic materials, playing a crucial role in the development of ceramics, semiconductors, catalysts, and energy storage systems. Unlike reactions in liquid or gaseous phases, they are limited by restricted atomic mobility and typically require elevated temperatures to enhance diffusion and overcome activation energy barriers. These reactions proceed through interfacial contact between solid reactants, followed by nucleation of product phases and …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 1, 2026 · pp. 10–14 Read article
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Investigation of Electronic Transport in Li2O and ZnO Nanoparticles Containing Polypyrrole Systems
Abstract: Polypyrrole systems having nanocrystalline ZnO and Li2O with different compositions (PPy50 + Li2Ox + ZnO(50-x), where x = 0, 2, 4, 6, 8, and 10) have been produced by ball milling. compositions of the type The temperature-dependent DC conductivity of each sample was determined in the temperature range of 313 K to 363 K. The conductivity studies show that Polaron hopping was the conducting mechanism in the material composites. The …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 88–95 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Medicinal Properties of Oxytenanthera abyssinica: A Narrative Review
Abstract: Oxytenanthera abyssinica, a plant local to the African landmass, has gotten a parcel of intrigued in later a long time for its conceivable restorative benefits; it has been utilized in conventional medication for decades since of its assumed mending capabilities. In spite of its long history, careful logical examination into its restorative potential is being attempted. This review paper explore into the multidimensional part of O. Abyssinica is in progressed …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
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Exploring the Synergy of High Performance Composite Concrete Strength and Sustainable Construction Practice
Abstract: This research evaluates how the combination of industrial waste materials optimizes composite concrete structure strength and services the interests of sustainable construction development. This research examines two major environmental problems stemming from ordinary Portland cement clinker manufacturing and landfill accumulation of non-biodegradable porcelain waste. The research employed alccofine dosage of 16% as a supplementary cementitious material (SCM) with high pozzolanic activity to combat these problems. Processed porcelain waste aggregates filled …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 47–58 Read article
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Flavonoid Contents and Antioxidant Activity of an Endophytic Bacteria Associated with Medicinal Plant Humulus lupulus
Abstract: Endophytes are symbiotic microorganisms, most often bacteria or fungi, that reside and multiply within plant tissues without inducing visible signs of disease or negatively affecting the host plant. Endophytic bacteria contribute to plant development by stimulating growth, strengthening defence mechanisms, enhancing tolerance to both abiotic and biotic stresses, and facilitating improved nutrient uptake. Endophytic bacteria serve as an important reservoir of bioactive compounds, notably antioxidant molecules, that play a crucial …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 1–6 Read article