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220 articles for “Multi-targeted”
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Health and Air Quality in High-Density Neighbourhoods of Delhi
Abstract: Delhi, one of the fastest-growing megacities in the world, continues to grapple with critical challenges of urban air pollution and its direct consequences on public health. High-density neighborhoods like Karol Bagh, Lajpat Nagar, Chandni Chowk, and East Delhi face disproportionately higher exposure to degraded air quality due to compact urban forms, overcrowding, mixed land use, and heavy traffic. This paper explores the interrelationship between air quality and health outcomes, emphasizing …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 3, Issue 2, 2025 · pp. 26–32 Read article
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In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
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A Comprehensive Review of Metabolite
Abstract: Metabolites, tiny chemicals, are essential to physiology, signalling, and biological function. This extensive review classifies metabolites into primary and secondary categories by biological relevance. Alkaloids, flavonoids, and terpenoids contribute to ecological interactions and defence systems, while amino acids, nucleotides, and carbohydrates directly affect development and cellular function. The article examines metabolic pathways, mass spectrometry, NMR, and metabolomics, a growing field. Metabolites play a crucial role in various scientific and practical …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Design and Analysis of Dispersion Flattened Low Loss Photonic Crystal Fiber
Abstract: AbstractThis paper demonstrates the study of triangular lattice hexagonal photonic crystal fiber with GeO2 doped core. The photonic crystal fiber (PCF) studied in this research work has a core doped with 97% molar concentrated GeO2 with seven layers of air-capillaries around the core. The design and analysis of optical characteristics, i.e., dispersion, confinement loss, and effective area have been studied extensively for optimizing the structure for a certain range of …
Published in Trends in Opto-electro & Optical Communication · Vol. 7, Issue 2, 2017 · pp. 41–50 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 27–40 Read article
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Review on Histological Effect of Lead on Liver and Kidney
Abstract: Our environment can be polluted by environmental toxins which are chemicals and other materials produced largely from industry and its products. There are large numbers of environmental toxicants which are potentially harmful to health. These large numbers of environmental toxicants can be divided into three major categories (heavy metals, air pollutants, and pesticides) and they are commonly studied environmental toxicants. Environmental toxins can be entered into the body by various …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 8–29 Read article
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Architectural Evolution of RISC Processors: From Early Research Prototypes to Modern Industrial Implementations
Abstract: This paper surveys the architectural evolution of Reduced Instruction Set Computer (RISC) architectures from early research prototypes to modern industrial processors, tracing four decades of design refinement across academic, embedded, server, mobile, and open- hardware ecosystems. Core ISA principles, pipeline evolution, compiler–hardware co-design, and quantitative performance modeling are analyzed through four representative industrial implementations: MIPS 74K, SPARC T4, ARM Cortex-A72, and SiFive U74 (RISC-V). Each processor is examined in terms …
Published in Journal of VLSI Design Tools and Technology · Vol. 16, Issue 2, 2026 · pp. 29–39 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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The Art of Drug Design and Process Chemistry
Abstract: The creation of safe and efficient medications depends heavily on the art of drug design and process chemistry. This multidisciplinary discipline designs and optimizes drug candidates for therapeutic uses by fusing the concepts of biology, chemistry, and engineering. Researchers can develop compounds with pharmacological activity by using logical drug design techniques if they have a thorough understanding of the molecular targets implicated in disease pathways. By making it easier to …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
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Progression in multi-omics and immunological research on host-parasite interactions: Transcriptomics, proteomics, genomics, metabolomics, and immune responses
Abstract: The interaction occuring between hosts and parasites is a quick and multi step-complex biological process that tries to influence disease outcomes. In recent years, multi-omics approaches, such as transcriptomics, proteomics, genomics, metabolomics, and immunological studies, have gathered substantial eye in dissecting these interactions at a microscopic level. These techniques enable a vast understanding of the molecular structures involved in parasitic infections and host defense mechanisms. This article reviews the advancements …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Pain Management in Rheumatoid Arthritis: Clinical Role and Therapeutic Implications of NSAIDs
Abstract: Rheumatoid arthritis (RA) is a progressive, chronic autoimmune condition that results in swelling in multiple joints. It is estimated to occur in 0.5–1% of the global population and is more common in women. India has an estimated prevalence of 0.75%. RA causes the destruction of joints and a decrease in disabilities and quality of life. It is accompanied by further manifestations and multiple co-occurring conditions that lead to a greater …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 4, Issue 1, 2026 · pp. 21–27 Read article
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Efficient Analysis and Minimization of Glitches using Threshold Swapped Combinational Clock Gating
Abstract: Nowadays design of electronic circuits to meet requirements like high speed, better functionality and low power is a tedious task. Power dissipation in any circuit comprises mainly two components: static power and dynamic power. The dynamic power heavily depends on the switching activity of the circuit. During the transistor switching transitions some spikes may occur, which are called as glitches. These glitches contribute 20–70% of the dynamic power and 20% …
Published in Journal of VLSI Design Tools and Technology · Vol. 5, Issue 2, 2015 · pp. 29–37 Read article
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The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Toward Comprehensive Immunization: The Role of Combined COVID-19 and Influenza Vaccines in Public Health
Abstract: The emergence of multi-pathogen vaccines, particularly those combining protection against COVID- 19 and influenza, marks a significant advancement in immunization efforts. These combination vaccines have the potential to streamline vaccination processes, improve vaccine uptake, and reduce the burden on healthcare systems by offering a single dose that targets both viruses. COVID-19 and seasonal influenza are major public health concerns, with overlapping symptoms and seasonal patterns that justify the rationale for …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 9–17 Read article
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Isolation and Characterization of Glucuronide Compound from Luffa Tuberosa (Roxb.) for Potential Applications in Polymer Chemistry
Abstract: This study explores the isolation process of glucuronide compounds from Luffa tuberosa (Roxb.) using an efficient and cost-effective method. The extracted compound, Gypsogenin-3β-O-β-D-Methyl glucuronide, is characterized using spectroscopic techniques such as IR, NMR, and Mass Spectrometry. The polymeric nature of glucuronide-based compounds and their potential applications in polymer and composite materials are discussed. The findings highlight the suitability of glucuronide derivatives in biomedical, pharmaceutical, and polymeric drug delivery systems. Additionally, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 566–572 Read article
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Autonomous Fire Suppression Robot Based on Arduino
Abstract: Fire hazards continue to pose serious risks in homes, workplaces, and industrial facilities, making rapid detection and early suppression crucial for minimizing damage and protecting lives. This paper presents the design and development of an autonomous fire suppression robot built around an Arduino- based control system. The robot is engineered to independently detect, approach, and extinguish small fires with minimal human interaction. It incorporates multiple sensing components, including flame sensors …
Published in Journal of Advancements in Robotics · Vol. 13, Issue 1, 2026 · pp. 26–32 Read article
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PROJECT PLANNING AND CONSTRUCTION USING ROBOTICS AND AUGMENTED REALITY
Abstract: The construction industry is based on human resources, specifically for on-site construction processes. The conventional construction practices require an absolute amount of workforce and skilled labour to achieve the aimed efficiency in terms of construction duration and cost, and building quality. Besides, lack of workforce and sufficiently skilled labour can affect the overall duration, cost, and quality targets. Therefore, based on these issues, advanced robotic technologies have been developed to …
Published in Journal of Mechatronics and Automation · Vol. 10, Issue 1, 2023 · pp. 1–6 Read article
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Thermo-hydraulic Performance of Multi-Pass Double-Pipe Heat Exchangers: Integrating Polymer Composite Tube Wall Materials via CFD Parametric Study and Experimental Validation
Abstract: Metallic materials such as steel and copper have traditionally dominated heat exchanger manufacturing because of their excellent thermal conductivity, mechanical strength, and long-established industrial reliability. However, their high weight, susceptibility to corrosion in aggressive operating environments, and inability to provide tunable thermal properties have motivated interest in alternative materials for next-generation thermal systems. Thermally conductive polymer composites reinforced with graphene nanoplatelets (GNP), boron nitride (BN), and carbon-based fillers offer an …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Nutritional Recovery Status and its Determinants of Targeted Supplementary Feeding Program among Pregnant and Lactating Women in Werie-Leke District, North Ethiopia, 2015
Abstract: In Ethiopia, around 1.5 million pregnant and lactating women (PLW) screened for acute malnutrition and those with moderate acute malnutrition (MAM) admitted to the targeted supplementary feeding program (TSFP). As the health system accepted, the TSFP is recognized as critical for the reduction of maternal morbidity and mortality in case of community emergency nutrition, but the recovery outcome was not measured yet. The study was undertaken to assess the nutritional …
Published in Research and Reviews: A Journal of Health Professions · Vol. 6, Issue 2, 2016 · pp. 21–30 Read article