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1907 articles for “Human epidermal growth factor receptors (HER-2)” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
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Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients. Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Challenges to Women's Adoption of the Human Papillomavirus Vaccine in India: An Updated Review
Abstract: The widespread availability of human papillomavirus (HPV) vaccines in some countries throughout the last ten years has demonstrated encouraging outcomes in reducing HPV infection and associated conditions including warts and precancerous lesions. We highlight vaccination coverage and efficacy in this study, which includes the most recent data on available HPV vaccinations. Furthermore, the topic of pan-gender immunisation and ongoing clinical trials is covered. Increasing vaccination coverage is now something that …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 21–30 Read article
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Assessing the Increasing Incidence of Prostate Cancer in Urban Delhi: Risk Factors, Early Detection, and Treatment Challenges
Abstract: Background: Prostate cancer has emerged as the second most prevalent cancer among men in India, with rapidly increasing incidence rates in urban areas like Delhi. This rise is attributed to urbanization, lifestyle changes (high-fat diets, tobacco use, sedentary behavior), increased life expectancy, and improved diagnostics. Despite its growing burden, low awareness, limited screening programs, and treatment barriers hinder early detection and effective management. This study examines the epidemiological trends, risk …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 21–28 Read article
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**Innovation and Quality Assurance in School Management: A Research Study on Indian Schools in the Context of NEP 2020**
Abstract: The quality of school education is strongly influenced by the efficiency and vision of school management practices. In today’s rapidly changing educational landscape, schools are expected to perform responsibilities that extend beyond routine administration. They must ensure academic excellence, learner well-being, value- based education, inclusion, transparency, and accountability to parents and society. However, many schools still function through traditional management patterns that focus mainly on record-keeping, examination routines, and compliance …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 16, Issue 1, 2026 Read article
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Investigation of Pollution Status in River No. 2, Freetown, Sierra Leone, Using Physicochemical and Bacterial Indicators
Abstract: This study assessed the physicochemical and bacteriological quality of surface water in the River No. 2 watershed, Sierra Leone, through monthly sampling from March–August 2024 at upstream, midstream, and downstream sites. Analyses included temperature, turbidity, pH, electrical conductivity, total dissolved solids, ammonia, fluoride, sulfite, nitrate, lead, arsenic, chromium, and microbial indicators (Escherichia coli, fecal and non-fecal coliforms). Most physicochemical parameters met WHO drinking-water guidelines. pH (7.0–7.3), TDS (7–17 mg/L), turbidity …
Published in International Journal of Pollution: Prevention & Control · Vol. 4, Issue 1, 2026 · pp. 11–27 Read article
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A Study to Assess the Risk Factors and Symptoms of Dialysis Disequilibrium Syndrome among Patients Undergoing Hemodialysis
Abstract: Dialysis Disequilibrium Syndrome (DDS) is a rare but potentially life-threatening neurological complication associated with hemodialysis, particularly during initiation or in high-risk patients. It is characterized by a spectrum of neurological manifestations ranging from mild symptoms such as headache and nausea to severe outcomes including seizures, coma, and death. Early identification of risk factors and prompt recognition of symptoms are crucial to prevent morbidity and mortality. The present study aimed to …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 Read article
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Antifungal Susceptibility Pattern of Candida Species Isolates from Dehradun City Hospitals
Abstract: The present investigation on the topic entitled “Antifungal susceptibility analysis of Candida species isolates from Dehradun City hospital.” was accomplished in the Doon University Microbiology laboratory (P.G.) and Hospital, Dehradun, Uttarakhand, during the period of February 2021 to July 2021. A total of 42 clinical samples were collected from patients, suspected of candidiasis from Dehradun city hospitals. Clinical samples were collected from oral cavity, blood, vaginal fluid and urine of …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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Factors Affecting Uptake of COVID-19 Vaccines Among Adults: A Cross Sectional Survey
Abstract: The COVID-19 vaccination started in phased manner in India, and it was first time when a digital platform was developed for vaccine site registration. People had skepticism about newly developed vaccines and had poor understanding of using digital platform for vaccination registration. It was one of the reasons for poor vaccination coverage in marginalized section of the society. The pandemic has also affected other healthcare services as people were worried …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 2, 2023 Read article
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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Exploring the Impact of Lattice Strain on the Debye-Waller Factor in Iron Nanoparticles: A Comprehensive Analysis
Abstract: This study systematically investigates the influence of lattice strain and particle size in iron powder produced through milling, employing X-ray powder diffraction. The determination of lattice strain (ε) and the Debye-Waller factor (B) is accomplished by analyzing Bragg reflection half-widths and integrated intensities. Significantly, the Debye-Waller factor exhibited a notable increase with lattice strain. By establishing a correlation between stress and the influential Debye-Waller factor, we derived a precise relationship …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 215–224 Read article
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Artificial Intelligence Threat to Human Activities
Abstract: This study explores the multifaceted impacts of Artificial Intelligence (AI) across human activities which must be employment, privacy, social interactions, proper decision-making, and also the ethical considerations. It tries to get closer to the bottom of AI's complicated behavior by focusing on its changes, problems, and moral roots in human activities. A careful review of the research shows where there are holes and gives a full picture of the dangers …
Published in Journal Of Network security · Vol. 12, Issue 1, 2024 · pp. 8–12 Read article
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Interplay of Thyroid Dynamics in Type 2 Diabetes: A Comprehensive Analytical Study at Government Medical College, Kota, and Affiliated Hospitals
Abstract: Diabetes mellitus is a prevalent endocrine metabolic condition that causes significant morbidity and mortality globally. Innumerable metabolic processes within our bodies depend on thyroid hormones. Excess or deficiency in insulin or thyroid hormones might cause functional problems. The intricate relationship between thyroid disorders and diabetes has been recognized for a considerable period. Patients with diabetes have been known to experience thyroid malfunction, the most prevalent kind of which is hypothyroidism. …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 6–11 Read article
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Impact of a Structured Educational Program on Awareness of the Human Papilloma Virus Vaccine for Cervical Cancer Prevention Among Women in a Chosen Rural Region of Rajkot
Abstract: The World Health Organization (WHO) advocates for the inclusion of the human papilloma virus (HPV) vaccine in standard immunization schedules worldwide, in addition to other preventive strategies. The launch of the prophylactic HPV vaccine has markedly improved primary prevention measures against cervical cancer and other diseases caused by HPV. Following their approval in 2006, both the quadrivalent and bivalent HPV vaccines have received authorization in over 100 countries. As of …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 18–22 Read article
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Designing a Pure Talent Management Model in the Growth Centers of Technological Units of Islamic Azad University with the Foundation's Data Approach
Abstract: Talent management is one of the management fields that has experienced the greatest growth in the last two decades. Due to its competitive nature, for the first time the concept of talent management was proposed in private organizations and large multinational companies and was widely welcomed. Therefore, the main goal of this research is to design a lean talent management model in Islamic Azad University technology development centers with a …
Published in International Journal of Sustainability · Vol. 1, Issue 1, 2024 · pp. 45–50 Read article
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Multi-factor Fused Lightpath QoT Prediction for Optical Networks: A Multiple Reservoir Analysis Strategy
Abstract: Investigating the channel quality of transmission (QoT) in-depth is crucial for responsive and instant transparent optical network management. However, current lightpath QoT predictions are devoted to univariate modeling. Due to the QoT metrics complicated time-varying process and the existing effects of inter-channel factors, despite the use of an advanced and efficient echo state network (ESN), it is difficult to obtain ideal results in univariate prediction mode. Thus, this paper considers …
Published in Trends in Opto-electro & Optical Communication · Vol. 14, Issue 1, 2024 · pp. 28–34 Read article
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Unmasking Hallucinations in Large Language Models Using Analysis of the LLAMA 2 Model and RAG Intervention
Abstract: The study describes the creation of a chatbot for financial trading called "TradeBot" and how it uses Retrieval Augmented Generation (RAG) to overcome the problem of producing false or unverifiable information, sometimes known as hallucinations. RAG allows the chatbot to refer to an external data source in addition to its taught knowledge, which increases the accuracy of its responses. The NCFM (NSE's Certification in Financial Markets) book was integrated as …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 1, 2025 · pp. 76–86 Read article
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Geotechnical Influence Factors in Empirical Design of Highway Pavement: The A123 Ilorin – Lokoja Highway, Nigeria Case Studies
Abstract: Site investigation and application of geological and geotechnical influence factors on the highway were investigated. Method involved field sampling, geotechnical laboratory and x-ray diffraction analysis and use of SRTM extracted slope and drainage parameters; and their integration in a GIS based multi-criteria decision analysis to derive a subgrade suitability map as a design tool. The suitability criteria classified the highway into four (4) design sections. Section one for very low …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 3, 2024 · pp. 53–70 Read article
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Precipitable Water for Human Consumption in Rural Areas: Calculation Method and Engineering Design
Abstract: This work describes a methodological process to estimate the precipitable water for human consumption as a function of meteorological parameters like ambient and dew point temperature, water vapor and ambient pressure, and relative humidity. The paper uses empirical correlations to determine the most accurate procedure for atmospheric rainwater, resulting in a simple relation between precipitable water and dew point temperature as the highest accurate one. The study shows the dew …
Published in Journal of Water Resource Engineering and Management · Vol. 11, Issue 3, 2024 · pp. 41–57 Read article
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Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article