Search
1947 articles for “4-dioxopyrimidine-5-carbonitrile” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
Nothing matched all of your words, so these match any of them.
-
Analytical Method Development and Validation for the Simultaneous Estimation of Elvitegravir and Cobicistat by RP-HPLC Method
Abstract: A new method was established for simultaneous estimation of Elvetigravir and Cobicistat by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Elvetigravir and Cobicistat by using Xterra C18 5 µm (4.6×150 mm) column, flow rate was 1 ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH 7: MEOH (30:70%v/v) (pH was adjusted with orthophosphoric acid), and the detection wave length was 270 nm. The instrument …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
-
Validation and Forced Degradation Studies for the Determination of Erlotinib in Bulk and Pharmaceutical Dosage Forms by RP-HPLC
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle size) in isocratic mode, using mobile phase composition of 0.1% orthophosphoric acid: Acetonitrile in the ratio of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 44–53 Read article
-
Preparation, Phytochemical Screening and Pharmacological Evaluation of Poly-herbal Formulation
Abstract: AbstractThe current investigation was endeavored at formulating and evaluating a poly-herbal formulation. The poly-herbal formulation was a combination of 10 herbal ingredients which was phyto-chemically screened for the detection of various phyto-constituents. The formulation was subjected to in vitro Anti-Arthritic and Anthelmintic activity studies. Anti-Arthritic activity was evaluated using various concentrations of the formulation (100 μg/ml, 250 μg/ml, and 500 μg/ml) and Diclofenac sodium (100 μg/ml, 250 μg/ml, and 500 …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 2, 2020 · pp. 9–14 Read article
-
A New RP-HPLC Method for Simultaneous Estimation of Atorvastatin and Fenofibrate in Its Bulk and Tablet Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Atorvastatin and Fenofibrate by RP-HPLC method. Methods: Chromatographic separations were carried using Phenomenex C18 column (4.6 × 250 mm, 5 µm) column with a mobile phase composition of 0.1 M Ammonium acetate:acetonitrile (60:40) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 with PDA detector at …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 12–18 Read article
-
Anti-Inflammatory Activity of Stem Bark of Homalium Zeylanicum Benth On Wistar Rats
Abstract: Due to the adverse effects of anti-inflammatory and anti-arthritic drugs, which are currently in clinical use, a need arises to develop newer anti-inflammatory and anti-arthritic agents with less side effects. The investigations of the efficacy of plant-based drugs used in the traditional medicine have evidenced great interest owing to their lesser side effects. In this context the present study was conceptualized to evaluate antioxidant and anti-inflammatory activity of Homalium zeylanicum …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 1, 2017 · pp. 39–50 Read article
-
Antibiotic prescribing patterns in paediatrics at a tertiary care hospital in Mansa, Zambia
Abstract: ABSTRACTBackground: Antibiotics are one of the most widely used groups of drugs. Irrational and uncontrolled use of these agents both in developing and developed countries has resulted in an evolution of resistant strains in addition to poor health outcome. Aim: The aim of this study was to evaluate the prescribing pattern of antibiotics for paediatrics using WHO prescribing indicators.Methods: A cross sectional Retrospective study was conducted at Mansa general hospital, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 3, 2022 · pp. 62–71 Read article
-
A Study and Report on Impact of Pharmacovigilance and Drug Safety Monitoring Practices in Promotion of Rational Drug Usage in General Medicine Departments of Hospital
Abstract: The present study reports on impact of pharmacovigilance and drug safety monitoring practices in promotion of rational drug usage in General Medicine Department of ESI hospital with an objective of identification and reporting of Drug Related Problems. It is a prospective observational study & conducted for a period of six months from November 2020 to April 2021. A sample size of 120 patients were randomly opted for this study, out …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 8, Issue 2, 2023 · pp. 24–40 Read article
-
Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
-
An Evidence Based Research on Impact and Validation of MFRS (medication fall risk score and evaluation tool) and DART (drug associated risk tool) and drug safety evaluation on special population (Geriatrics, Pregnancy and lactating Women)
Abstract: The topics and subjects studied and reported in this project work is very less frequently discussed and studied on the special population. It is a very important matter to discuss on and to find some conclusions so that the special patient groups like pregnant, lactating, and geriatric patients can be treated and taken care of well. These most sensitive patient populations that need the best treatment and often health care …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 33–51 Read article
-
A Study To Assess The Knowledge Regarding Dash Diet Among Hypertensive Patients Admitted At Dr. B.R. Ambedkar Medical College And Hospital With A View To Develop Informational Pamphlet.
Abstract: Objective: The objective was to assess the knowledge regarding DASH diet among hypertensive patients admitted at DR. B.R Ambedkar Medical College and Hospital.Resaerch Approach:Quantitative Approach,Design: Descriptive study. Conceptual Framework: Modified Conceptual Framework On Revised Pender’s Health Promotion Model (1980’s), Reframed By S.Saddle River, N.J Prentile Hall.Sampling Size: 25 hypertensive patients,Sampling Technique:Purposive sampling technique.Data were collected using the structured knowledge questionnaire.Data Analysis And Interpretation: Descriptive and Inferential statistics. Results:Among 25 samples, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 3, 2023 · pp. 22–32 Read article
-
Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in its Bulk and Pharmaceutical Dosage Form
Abstract: A straightforward, exact, precise and sensitive UV spectrophotometric assay technique and a basic and sensitive colorimetric assay method have been created and validated for the quantitative estimation of Ritonavir from bulk drug and tablet formulations. UV spectrophotometric strategy which includes the assurance of Ritonavir in bulk medication and pharmaceutical dosage forms and has an assimilation greatest at 240 nm in methanol. The Beer's law was obeyed over the concentration range …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 32–41 Read article
-
HPTLC Fingerprinting of Isoflavonoids and Metabolites Quantification from in vivo and in vitro Developed Parts of Pueraria tuberosa (Willd.) DC
Abstract: Pueraria tuberosa (Willd.) DC, a medicinally important plant, produces different types of isoflavonoids including Genestein. This plant requires conservation. In present study, callus was developed from in vivo tuber and in vitro seedling. Murashige and Skoog medium supplement with combination of BAP (6-Benzylaminopurine) (1.5mg/l) and 2,4-D (1.5mg/l) were found to be more effective. Fresh in vitro shoots produced from nodal explants of in vitro germinated seedling on MS medium supplement …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 34–45 Read article
-
RP-HPLC Method for the Simultaneous Estimation of Hydrocodone and Pseudoephedrine in Pharmaceutical Dosage Form
Abstract: A simple, rapid, specific, accurate and precise high-performance liquid chromatographic method was developed for the estimation of Hydrocodone and Pseudoephedrine in pharmaceutical dosage forms. Phenomenex C18 (250×2.2 mm ID) 4.5 µm was the column used. Methanol: Water: TEA (Tri ethyl amine) in the ratio of 50:50:0.5% (v/v/v) was the optimized mobile phase and pH was adjusted to 7.5 by using ortho-phosphoric acid. The flow rate was 1.0 ml/min and effluents …
Published in Trends in Drug Delivery · Vol. 7, Issue 1, 2020 · pp. 17–24 Read article
-
Virtual Screening of Novel 2-substituted -5-hydroxy-1- (2-methyl-3-morpholinopropyl)-1H-indole-3- carboxamide Derivatives for Estrogen Receptor alpha in AF-2 domain for effective Anticancer Treatment
Abstract: Present manuscript describes designing of novel 2-substituted -5-hydroxy-1-(2-methyl-3- morpholinopropyl)-1H-indole-3-carboxamide derivatives as specific ERα modulators, discuss the selection criteria for 1ERR, several interactions between the ligand and the amino acid residues that would probably elicit fruitful modulation of the receptor. Accordingly, a ligand was observed to yield Gscore of -10.016 which was found comparable with the standard ligand Raloxifene (-11.869). The present work has been designed to discover some novel 2-substituted …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 31–55 Read article
-
Simultaneous Estimation of Prazosin and Polythiazide in Bulk and Fixed Dose Combination (Tablets) by RP-HPLC
Abstract: Objective:A New method was established for simultaneous estimation of Prazosin and Polythiazide by RP-HPLC method. Methods:Chromatographic separations were carried using HPLC equipped with Auto Sampler and PDA Detector, Discovery (150 x 46 mm, 5mm) column with a mobile phase composition of Buffer and ACN: taken in the ratio 60:40 (60:40 v/v) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 66–74 Read article
-
New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article
-
A Study to Assess the Add-on Impact of Ayurvedic Management along with Ongoing Conventional Treatment of Diabetes Mellitus: A Randomized Clinical Trial
Abstract: Diabetes affects millions and thus is a major public health disease among with adults aged 30+. Available treatment although helps but many develop other side effects to complicate the issue. Ayurveda offers options to manage diabetes without complications. Present study is to see the add-on effect of Ayurveda therapy among persons on modern medicines. Ayurveda D4 combination is Jamunbeej and Gudmarpatra 5 gm churna each before breakfast and dinner and …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · pp. 15–22 Read article
-
Study of Behavior of Buckling Restrained Bearing Frame Along with Soil Structure Interaction
Abstract: Lateral forces due to earthquake are the major consideration for design of earthquake resisting structures, these forces can be resisted by various systems like braced frames, shear walls, moment frames, etc. Energy dissipation is one of the most convenient option for earthquake resistance, as it can absorb input energy from earthquake protecting the main structure. Past research revealed that the Buckling Restrained Braces (BRB) are the best type of energy …
Published in Journal of Construction Engineering, Technology & Management Read article
-
Mechanical Performance Degradation of Naturally Aged Nitrile Butadiene Rubber in Low Frequency Range...
Abstract: For good mechanical design, damping is often still an invisible requirement. Nitrile Butadiene Rubber (NBR) has a wide range of applications as a damping and sealing material. To offer the long-term service of NBR, it is important to estimate the degradation of modal properties under complex mechanical and environmental loading. The present work aims to correlate the experimental data with generalized higher-order Maxwell models and curve fitting techniques to find …
Published in Journal of Polymer & Composites · Vol. 10, Issue 1, 2022 · pp. 68–79 Read article
-
Studies on Mechanical, Optical, Barrier Properties and Characterization of LDPE-PLA Blend Films with Micro Clay
Abstract: Low density poly ethylene (LDPE) and Poly lactic acid (PLA) in the ratio of 70:30 wt% were blended along with ethylene glycidyl meth acrylate (EGMA) as compatibilizer (2.5%), benzophenone as photodegradable additive (1%) and microclay (1,3,5%) as filler. Blending took place in a twin-screw extruder and then the resulting blend was processed into a film using blown film extrusion. Mechanical, optical, barrier and degradative properties of film were tested as …
Published in Journal of Polymer & Composites · pp. 56–66 Read article