Search
171 articles for “drug discovery and development”
-
In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
-
Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes
Abstract: Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 2, 2021 · pp. 1–14 Read article
-
Magnetic ZnxFe2–xO3 Nanoparticles Enhanced Nanobiosensor Integrated with MOSFETs for Efficient Detections of Biomolecules and Cancerous Cells
Abstract: The human brain is mostly responsible for intelligence and consciousness. An artificial equivalence of this action is nanobiosensor, which is used in artificial intelligence. The need for nanodiagnostics platforms for detecting diseases at the genetic, molecular, and cellular level has triggered the development of nanobiosensors integrated with MOSFETs. This device enables simple, inexpensive rapid tests, accurate imaging methods, and accurate molecular diagnosis at point-of-care (POC). This device is seen as …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 3, 2024 · pp. 33–44 Read article
-
A Comparative Review on Abelmoschus palianus and Barleria mysorensis: Phytochemical Constituents, Pharmacological Potentials, and Ethnobotanical Significance
Abstract: Medicinal plants have long served as invaluable resources for treating human ailments, with countless species still awaiting scientific exploration and validation. Abelmoschus palianus and Barleria mysorensis are two such botanicals with rich ethnomedicinal heritage but limited pharmacological characterization. This review presents a detailed comparative analysis of these two species, examining their botanical descriptions, geographic distribution, traditional applications, phytochemical constituents, pharmacological properties, toxicological profiles, and therapeutic potential. Abelmoschus palianus, native to …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 7–13 Read article
-
Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
-
Current Updates On Employability Of Artificial Intelligence In Healthcare Science & Research
Abstract: Over the centuries, tools have been developed to increase refinement to manipulate different tools in many ways to use human digital computers. It can perform the same types of numerical and symbolic operations that can be done by ordinary people, but faster and more reliable. Artificial intelligence algorithms applied to computer applications and software. Include knowledge-based systems. AI is the science that mimics the mental skills of humans in computers. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 72–77 Read article
-
Applications of Computational Biology and Bioinformatics: An Overview
Abstract: Bioinformatics is a multidisciplinary science that combines biology, mathematics, and computer science. The use of computer science to handle biological data in order to decode plant genomes is known as bioinformatics. More than a decade ago, the science of bioinformatics arose as a tool to aid biological discoveries. The creation of the Human Genome Project (HGP) resulted in a tremendous rise in biological data. Capturing, managing, processing, analysing, and interpreting …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 20–24 Read article
-
Liposomes as Therapeutic Vehicles: Advancing Targeted Drug Delivery in Healthcare
Abstract: Liposomes represent an innovative approach to targeted drug delivery. These tiny, lipid-based vesicles can encapsulate medications, allowing them to travel directly to diseased cells while minimizing impact on healthy tissues. By using liposomes, medications can improve their effectiveness while reducing side effects, leading to better overall treatment results.. Their structure enables a controlled release of the drug, which can be particularly beneficial for therapies requiring sustained action. This technology holds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 39–46 Read article
-
In Silico Tau Protein Kinase I Inhibitory Activity of Some Commercially Available Flavonoids
Abstract: Molecular docking is a frequently used tool in computer-aided structure-based rational drug design. Flavonoids are a group of natural products which exhibits various biological and pharmacological activities. The primary objective of this study was to investigate the tau protein kinase I inhibitory activity of flavonoids using in silico docking studies. Memantine, a known neuro-receptor antagonist is currently used in the treatment of Alzheimer’s disease (AD). In silico docking studies were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 6–12 Read article
-
Phytoconstituents of Ticanto crista (L.) R. Clark & Gagnon (Caesalpiniaceae): A Review
Abstract: Ticanto crista (L.) R. Clark & Gagnon (= Caesalpinia crista L.), a member of the Leguminosae family, is a medicinally important plant traditionally used in various systems of medicine, including Ayurveda, for treating a wide range of ailments. It has attracted increasing scientific interest due to its rich phytochemical profile and therapeutic potential. This review serves as a comprehensive index of the chemical structures of common and medicinal compounds isolated …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 38–59 Read article
-
CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
-
In Silico Study of Histone Deacetylase Inhibitor as Anticancer Agents
Abstract: The clinical selective histone deacetylase inhibitor vorinostat is most commonly used for the treatment of lymphoma and solid tumor and has been preventing lives worldwide. Vorinostat is used in both treatment and prevention of lymphoma and other tumors. Based on these for current study some vorinostat derivatives with thiadiazole moiety containing derivatives have been designed for in silico study. For present work, the already selected study was against histone human …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 6–23 Read article
-
Ligand Efficiency in Relation to 3D Physicochemical Characters of Novel HIV-1 Vif Antagonist: An Approach in The Optimization of HIV Drugs
Abstract: AbstractLigand efficiency is a design framework commonly used in drug discovery. Thirty-six (36) newly discovered 1,2,3-triazole analogues as potent new inhibitors of HIV-1 Vif were subjected to quantitative structure-property relationship (QSPR) modeling to predict their ligand efficiencies (LE) in an attempt to improve/optimize it by using some numerical data of HIV-1 Vif inhibitors based on their physical and chemical properties (descriptors). Various 3D physicochemical properties or descriptors were calculated from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 50–59 Read article
-
Evaluation of Antiulcer Activity of Allamanda cathartica Aqueous Leaf Extract in Experimental Rat Models
Abstract: A peptic ulcer is an open sore that forms on an epithelial surface of the stomach. To decrease the incidence of relapses, side effects, drug interactions of the existing drugs, and to increase the use of available phytochemicals, this present study was aimed to evaluate the antiulcer activity of Allamanda cathartica using pyloric ligation induced gastric ulcer model and Aspirin-induced gastric ulcer model. In pyloric ligation induced gastric ulceration model, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 1, 2020 · pp. 24–31 Read article
-
An Insight to Epidemiology, Diagnosis and Treatment of COVID-19
Abstract: Abstract Since late December, 2019 an outbreak of a novel coronavirus disease was reported in Wuhan, China with severe acute respiratory syndrome (SARS). It is commonly known as COVID-19 means a disease caused by coronavirus and the first case was identified in 2019. The WHO declared the COVID-19 a global pandemic in March, 2020 because it affected more than 100 countries worldwide. In this review we summarize epidemiology, diagnosis and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 2, 2020 · pp. 13–22 Read article
-
Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 10–27 Read article
-
A Review on the Clinical and Pathological Significance of Prorenin Receptor [(P)RR]
Abstract: The (pro)renin receptor (P)RR discovery, which is a novel constituent of Renin Angiotensin-Aldosteron System (RAS) has brought renin and (pro)renin back into spotlight. The (P)RR binds both renin and its inactive precursor (pro)renin, this binding triggers a cascade of intracellular signalling that eventually leads to upregulation of the expression of profibrotic genes, potentially leading to pathogenesis of cardiac and renal fibrosis, growth and remodelling. Clinically, it is also seen that …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 11–17 Read article
-
Novel Strategic Framework for AI-Driven Discovery and Development of Smart and Sustainable Polymers in Healthcare
Abstract: The development of new smart and sustainable polymers is emerging as a priority of new health care innovative development, but event before it may be actualized, the usual culprit is the delay and unproductive execution of the old-fashioned R&D efforts. The current paper proposes a strategic plan which will solve all these shortcomings and speed up the material discovery process by using Artificial Intelligence (AI) and Machine Learning (ML). The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1535–1550 Read article
-
Microwave Aided Ecological Forced Degradation Method for the Rapid Exploration of the Drug Impurity: Literature Investigated UP TO the Time Point
Abstract: The drug development life cycle is a time-consuming process, which also involves lots of efforts in the testing of the chemical stability of the drug molecules and possible impurity and degradation product of the drug before it comes in the form of a stable formulation. The Forced degradation and stability testing involves the major time portion in researching the chemistry of the molecules. With the aim of getting a green …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 3, 2020 · pp. 23–27 Read article
-
Anti Covid-19 Drugs Suggested by Computational Methods: A Review
Abstract: Background and aims: Long COVID refers to the persistence of illness in individuals who have survived from COVID-19 infection. This article reviews long covid and the use of in silico techniques in drug development for COVID-19. Results: Many COVID-19 survivors have long COVID, which has become a burden in daily life. Various attempts have been undertaken to relieve symptoms and manage it, but there is no cure as of yet. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 16–34 Read article