STM Journals Peer-reviewed research from Consortium e-Learning Network

Research & Reviews: A Journal of Drug Design & Discovery Review Article

Liposomes as Therapeutic Vehicles: Advancing Targeted Drug Delivery in Healthcare

  1. Varsha R. Gaikwad Department of Pharmacognosy, Shri Pandit Baburao Chaughule College of Pharmacy
  2. Shaikh Sabiya Department of Pharmaceutical Chemistry, Shri Pandit Baburao Chaughule College of Pharmacy
  3. Sahil Khan Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi
  4. Tariq Choudhary Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi
  5. Aayush Kesarwani Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi
  6. Nehad Ansari Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi
  7. Anzal Ansari Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi
  8. Ambika Nand Jha Department of Pharmacy Practice, School of Pharmacy, Sharda University

Abstract

Liposomes represent an innovative approach to targeted drug delivery. These tiny, lipid-based vesicles can encapsulate medications, allowing them to travel directly to diseased cells while minimizing impact on healthy tissues. By using liposomes, medications can improve their effectiveness while reducing side effects, leading to better overall treatment results.. Their structure enables a controlled release of the drug, which can be particularly beneficial for therapies requiring sustained action. This technology holds promise for various medical applications, including cancer treatment and vaccine delivery, making it a significant advancement in improving how we administer and target therapeutic agents within the body. The unique structure of liposomes allows for controlled drug release, which is particularly advantageous for therapies necessitating sustained action over time. In the context of oncology and genetic disorders, liposomes are revolutionizing treatment paradigms. Their capacity to encapsulate various therapeutic agents, such as small molecules, proteins, and nucleic acids, allows for targeted delivery to specific tissues in need. Their unique ability to encapsulate therapeutic agents allows for targeted delivery directly to affected cells, minimizing side effects and enhancing treatment efficacy. By modifying the liposome’s surface, researchers can create formulations that selectively bind to specific cell types, making them invaluable for personalized medicine. This focused strategy enhances patient outcomes and paves the way for the development of novel therapies. As research advances, liposomes hold great promise for transforming how we approach disease treatment and management, paving the way for more effective and individualized healthcare In this article, we will delve into the intriguing history of liposomes, tracing their discovery and examining their various applications in the medical field. We’ll delve into how they function, enabling targeted delivery of drugs and enhancing treatment efficacy. Their ability to encapsulate various therapeutic agents has led to breakthroughs in treating conditions like cancer and genetic disorders. With ongoing research, liposomes continue to reveal new possibilities in personalized medicine, transforming patient care.

Keywords

References (28)

  1. Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyon. 2022;8(5):e09394. doi:10.1016/j.heliyon.2022.e09394
  2. Liu P, Chen G, Zhang J. A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives. Molecules. 2022;27(4):1372. doi:10.3390/molecules27041372
  3. Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et al. Liposome: classification, preparation, and applications. Nanoscale Research Letters. 2013;8(1). doi:10.1186/1556-276x-8-102
  4. Trucillo P, Campardelli R, Reverchon E. Liposomes: From Bangham to Supercritical Fluids. Processes. 2020;8(9):1022. doi:10.3390/pr8091022
  5. Hamid MSS, Hatwar PR, Bakal RL, Kohale NB. A comprehensive review on Liposomes: As a novel drug delivery system. GSC Biol Pharm Sci. 2024;27(1):199–210. doi:30574/gscbps.2024.27.1.0121.
  6. Zafar MN, Abuwatfa WH, Husseini GA. Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes. Pharmaceutics. 2023;15(2):421. doi:10.3390/pharmaceutics15020421
  7. Loscertales E, Mateo J, España S. A comparative study of sensitizers and liposome composition in radiation-induced controlled drug release for cancer therapy. Journal of Liposome Research. 2024;35(1):64-75. doi:10.1080/08982104.2024.2401800
  8. Paweletz LC, Labedzki N, Günther Pomorski T. Micro-scale quantitative analysis of sterol content in liposomes. Journal of Liposome Research. 2024;35(1):86-93. doi:10.1080/08982104.2024.2388146
  9. Allen TM, Cullis PR. Liposomal drug delivery systems: From concept to clinical applications. Advanced Drug Delivery Reviews. 2013;65(1):36-48. doi:10.1016/j.addr.2012.09.037
  10. Hamad I, Harb AA, Bustanji Y. Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements. Pharmaceutics. 2024;16(3):400. doi:10.3390/pharmaceutics16030400
  11. Tretiakova DS, Vodovozova EL. Liposomes as Adjuvants and Vaccine Delivery Systems. Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 2022;16(1):1-20. doi:10.1134/s1990747822020076
  12. Olusanya T, Haj Ahmad R, Ibegbu D, Smith J, Elkordy A. Liposomal Drug Delivery Systems and Anticancer Drugs. Molecules. 2018;23(4):907. doi:10.3390/molecules23040907
  13. Shrestha S. Liposomal formulations in cancer immunotherapy: Recent advancements and future challenges. Cancer Immunol Immunother 2019;68(4):603–616.
  14. Mahmood A, Bernkop-Schnürch A. SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs. Advanced Drug Delivery Reviews. 2019;142:91-101. doi:10.1016/j.addr.2018.07.001
  15. Reimondez-Troitiño S, González-Aramundiz JV, Ruiz-Bañobre J, López-López R, Alonso MJ, Csaba N, et al. Versatile protamine nanocapsules to restore miR-145 levels and interfere tumor growth in colorectal cancer cells. European Journal of Pharmaceutics and Biopharmaceutics. 2019;142:449-459. doi:10.1016/j.ejpb.2019.07.016
  16. Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater. 2013;12(11):991–1003. doi:10.1038/nmat3681.
  17. D'Apolito R, Tomaiuolo G, Taraballi F, Minardi S, Kirui D, Liu X, et al. Red blood cells affect the margination of microparticles in synthetic microcapillaries and intravital microcirculation as a function of their size and shape. Journal of Controlled Release. 2015;217:263-272. doi:10.1016/j.jconrel.2015.09.013
  18. Vyas SP, Singh S. Nanoparticles for targeted and controlled drug delivery. Drug Deliv Transl Res. 2012;2(5):241–256.
  19. Raghavan K, Chen J, Yu Y. Nanocarriers for the delivery of drugs: a review. Front Pharmacol. 2016;7. doi:10.3389/fphar.2016.00391.
  20. Klibanov AL, Maruyama K, Beckerleg AM. Liposome-mediated drug delivery: a critical review. J Drug Target. 2014;22(6):481–490. doi:10.3109/1061186X.2014.900691.
  21. Sjöholm E, Sandler N. Additive manufacturing of personalized orodispersible warfarin films. International Journal of Pharmaceutics. 2019;564:117-123. doi:10.1016/j.ijpharm.2019.04.018
  22. Hajj KA, Whitehead KA. Tools for translation: non-viral materials for therapeutic mRNA delivery. Nature Reviews Materials. 2017;2(10). doi:10.1038/natrevmats.2017.56
  23. Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nature Reviews Drug Discovery. 2005;4(2):145-160. doi:10.1038/nrd1632
  24. de Jong. Drug delivery and nanoparticles: Applications and hazards. International Journal of Nanomedicine. 2008:133. doi:10.2147/ijn.s596
  25. Miyazaki Y, Uchino T, Kagawa Y. Compounding of low-dose pharmaceutical powders using a planetary centrifugal mixer. Journal of Drug Delivery Science and Technology. 2019;52:103-109. doi:10.1016/j.jddst.2019.04.007
  26. Buck ML. Pharmacokinetic Changes During Extracorporeal Membrane Oxygenation. Clinical Pharmacokinetics. 2003;42(5):403-417. doi:10.2165/00003088-200342050-00001
  27. Szoka FC. Liposomal Drug Delivery: Current Status and Future Prospects. 1st Boca Raton, FL: CRC Press; 2019. 845–890.
  28. Fulton MD, Najahi-Missaoui W. Liposomes in Cancer Therapy: How Did We Start and Where Are We Now. International Journal of Molecular Sciences. 2023;24(7):6615. doi:10.3390/ijms24076615
Support