Journal of Nanoscience, NanoEngineering & Applications Review Article

Magnetic ZnxFe2–xO3 Nanoparticles Enhanced Nanobiosensor Integrated with MOSFETs for Efficient Detections of Biomolecules and Cancerous Cells

  1. Gizachew Diga Department of Physics, Jimma University

Abstract

The human brain is mostly responsible for intelligence and consciousness. An artificial equivalence of this action is nanobiosensor, which is used in artificial intelligence. The need for nanodiagnostics platforms for detecting diseases at the genetic, molecular, and cellular level has triggered the development of nanobiosensors integrated with MOSFETs. This device enables simple, inexpensive rapid tests, accurate imaging methods, and accurate molecular diagnosis at point-of-care (POC). This device is seen as an innovative approach in detecting pathogens causing disease and drug discovery. In this paper, a magnetic nanoparticles-enhanced MOSFET-integrated nanobiosensor is presented. The MOSFET equation is formulated to explore the connection between various physical parameters. Then the impact of these parameters on the amplification and image resolution is discussed. The study revealed that MOSFET integrated magnetic ZnxFe2–xO3 nanoparticles-based nanobiosensors exhibit amplification, image resolution, sensitivity, and specivity in detecting biological organisms, biomolecules, and epidemic diseases, such as cancer.

Keywords

References (46)

  1. Syu YC, Hsu WE, Lin CT. Review—Field-Effect Transistor Biosensing: Devices and Clinical Applications. ECS Journal of Solid State Science and Technology. 2018;7(7):Q3196-Q3207. doi:10.1149/2.0291807jss
  2. Reddy B, Dorvel BR, Go J, Nair PR, Elibol OH, Credo GM, et al. High-k dielectric Al2O3 nanowire and nanoplate field effect sensors for improved pH sensing. Biomedical Microdevices. 2011;13(2):335-344. doi:10.1007/s10544-010-9497-z
  3. Haun JB, Yoon TJ, Lee H, Weissleder R. Magnetic nanoparticle biosensors. WIREs Nanomedicine and Nanobiotechnology. 2010;2(3):291-304. doi:10.1002/wnan.84
  4. Landry CJ, Burns FP, Baerlocher F, Ghandi K. Novel Solid‐State Microbial Sensors Based on ZnO Nanorod Arrays. Advanced Functional Materials. 2018;28(19). doi:10.1002/adfm.201706309
  5. Yang Y, Xiang Y, Qi X. Design of Photonic Crystal Biosensors for Cancer Cell Detection. Micromachines. 2023;14(7):1478. doi:10.3390/mi14071478
  6. Ramzannezhad A, Bahari A, Hayati A, Najafi-Ashtiani H. Magnetic nanobiosensors in detecting Microalbuminuria (MAU), using Fe3O4 nanorods synthesized via microwave-assisted method. Materials Science and Engineering: B. 2021;268:115123. doi:10.1016/j.mseb.2021.115123
  7. Feng L, Song S, Li H, He R, Chen S, Wang J, et al. Nano-Biosensors Based on Noble Metal and Semiconductor Materials: Emerging Trends and Future Prospects. Metals. 2023;13(4):792. doi:10.3390/met13040792
  8. Touhami A. Biosensors and nanobiosensor: Design and applications. Nanomed. 2014;31(5):498–473.
  9. Tyagi S, Chaudhary M, Ambedkar AK, Sharma K, Gautam YK, Singh BP. Metal oxide nanomaterial-based sensors for monitoring environmental NO 2 and its impact on the plant ecosystem: a review. Sensors & Diagnostics. 2022;1(1):106-129. doi:10.1039/d1sd00034a
  10. Karki K, Bisht R, Shahi KS, Ranga R, Malik U. Nano-Biosensors for Cancer Diagnostics: Current Status and Future Prospects. Journal of Nanoscience and Technology. 2019;5(4):797-801. doi:10.30799/jnst.260.19050415
  11. Bergveld P. The impact of MOSFET-based sensors. Sensors and Actuators. 1985;8(2):109-127. doi:10.1016/0250-6874(85)87009-8
  12. Schöning MJ, Poghossian A. Recent advances in biologically sensitive field-effect transistors (BioFETs). The Analyst. 2002;127(9):1137-1151. doi:10.1039/b204444g
  13. Ognjanović M, Stanković DM, Ming Y, Zhang H, Jančar B, Dojčinović B, et al. Bifunctional (Zn,Fe)3O4 nanoparticles: Tuning their efficiency for potential application in reagentless glucose biosensors and magnetic hyperthermia. Journal of Alloys and Compounds. 2019;777:454-462. doi:10.1016/j.jallcom.2018.10.369
  14. Boisseau P, Loubaton B. Nanomedicine, nanotechnology in medicine. Comptes Rendus. Physique. 2011;12(7):620-636. doi:10.1016/j.crhy.2011.06.001
  15. Evtugyn G. Biochemical Components Used in Biosensor Assemblies. Lecture Notes in Chemistry. 2013:21-97. doi:10.1007/978-3-642-40241-8_2
  16. Khan S, Mahmud SA. Metal oxide semiconductor field effect transistor; fundamentals, essentials and models. RG. 2020;2(2). doi:10.13140/RG.2.2.11051.26406.
  17. TAUFIQ A, YULIANTIKA D, SUNARYONO S, SAPUTRO RE, HIDAYAT N, MUFTI N, et al. Hierarchical Structure and Magnetic Behavior of Zn-Doped Magnetite Aqueous Ferrofluids Prepared from Natural Sand for Antibacterial Agents. Anais da Academia Brasileira de Ciências. 2021;93(4). doi:10.1590/0001-3765202120200774
  18. Kasparis G, Sangnier AP, Wang L, Efstathiou C, LaGrow AP, Sergides A, et al. Zn doped iron oxide nanoparticles with high magnetization and photothermal efficiency for cancer treatment. Journal of Materials Chemistry B. 2023;11(4):787-801. doi:10.1039/d2tb01338j
  19. Tripathy N, Kim DH. Metal oxide modified ZnO nanomaterials for biosensor applications. Nano Convergence. 2018;5(1). doi:10.1186/s40580-018-0159-9
  20. Akram MW, Alam MF, Ji HN, Mahmood A, Munir T, Iqbal MZ, et al. Chitosan blend iron oxide nanostructure-based biosensor for healthy & malignant tissue glucose/urea detection. IOP Conference Series: Materials Science and Engineering. 2019;474:012060. doi:10.1088/1757-899x/474/1/012060
  21. Su PC, Chen BH, Lee YC, Yang YS. Silicon Nanowire Field-Effect Transistor as Biosensing Platforms for Post-Translational Modification. Biosensors. 2020;10(12):213. doi:10.3390/bios10120213
  22. Chang SM, Palanisamy S, Wu TH, Chen CY, Cheng KH, Lee CY, et al. Utilization of silicon nanowire field-effect transistors for the detection of a cardiac biomarker, cardiac troponin I and their applications involving animal models. Scientific Reports. 2020;10(1). doi:10.1038/s41598-020-78829-7
  23. Lin CW, Chang CC. Breast cancer detection using surface plasmon resonance based. Biosens. 2014;229. doi:10.1201/b12737-15.
  24. Macchia E, Picca RA, Manoli K, Di Franco C, Blasi D, Sarcina L, et al. About the amplification factors in organic bioelectronic sensors. Materials Horizons. 2020;7(4):999-1013. doi:10.1039/c9mh01544b
  25. Hasanzadeh M, Shadjou N, de la Guardia M. Iron and iron-oxide magnetic nanoparticles as signal-amplification elements in electrochemical biosensing. TrAC Trends in Analytical Chemistry. 2015;72:1-9. doi:10.1016/j.trac.2015.03.016
  26. Ortiz-Casas B, Galdámez-Martínez A, Gutiérrez-Flores J, Baca Ibañez A, Kumar Panda P, Santana G, et al. Bio-acceptable 0D and 1D ZnO nanostructures for cancer diagnostics and treatment. Materials Today. 2021;50:533-569. doi:10.1016/j.mattod.2021.07.025
  27. Sebastian V, Gimenez M. Teaching Nanoscience and Thinking Nano at the Macroscale: Nanocapsules of Wisdom. Procedia - Social and Behavioral Sciences. 2016;228:489-495. doi:10.1016/j.sbspro.2016.07.075
  28. Dahiya RS, Metta G, Valle M. Piezoelectric polymer oxide semiconductor field effect transistor (POSFET) devices for touch sensing. 2009 2nd International Workshop on Electron Devices and Semiconductor Technology. 2009:1-5. doi:10.1109/edst.2009.5166118
  29. Ben-Hamo R, Jacob Berger A, Gavert N, Miller M, Pines G, Oren R, et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers. Nature Communications. 2020;11(1). doi:10.1038/s41467-020-17090-y
  30. Serban I, Enesca A. Metal oxide-based semiconductors for biosensor applications. Front Chem. 2020;8:354. doi:10.3389/fchem.2020.00354.
  31. Nwosu A, Boardman S, Husain MM, Doraiswamy PM. Digital therapeutics for mental health: Is attrition the Achilles heel? Frontiers in Psychiatry. 2022;13. doi:10.3389/fpsyt.2022.900615
  32. Liang H, Liu Y, Qileng A, Shen H, Liu W, Xu Z, et al. PEI-coated Prussian blue nanocubes as pH-Switchable nanozyme: Broad-pH-responsive immunoassay for illegal additive. Biosensors and Bioelectronics. 2023;219:114797. doi:10.1016/j.bios.2022.114797
  33. Tripathy A, Nine MJ, Silva FS. Biosensing platform on ferrite magnetic nanoparticles: Synthesis, functionalization, mechanism and applications. Advances in Colloid and Interface Science. 2021;290:102380. doi:10.1016/j.cis.2021.102380
  34. Adampourezare M, Hasanzadeh M, Hoseinpourefeizi MA, Seidi F. Iron/iron oxide-based magneto-electrochemical sensors/biosensors for ensuring food safety: recent progress and challenges in environmental protection. RSC Advances. 2023;13(19):12760-12780. doi:10.1039/d2ra07415j
  35. Banigo A, Azeez T, Ejeta K, Lateef A, Ajuogu E. Nanobiosensors: applications in biomedical technology. IOP Conference Series: Materials Science and Engineering. 2020;805(1):012028. doi:10.1088/1757-899x/805/1/012028
  36. Crossley L, Attoye B, Vezza V, Blair E, Corrigan D, Hannah S. Establishing a Field-Effect Transistor Sensor for the Detection of Mutations in the Tumour Protein 53 Gene (TP53)—An Electrochemical Optimisation Approach. Biosensors. 2019;9(4):141. doi:10.3390/bios9040141
  37. Wei K, Zhao S, Zhang W, Zhong X, Li T, Cui B, et al. Controllable Synthesis of Zn-Doped α-Fe2O3 Nanowires for H2S Sensing. Nanomaterials. 2019;9(7):994. doi:10.3390/nano9070994
  38. Rim KT, Song SW, Kim HY. Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review. Safety and Health at Work. 2013;4(4):177-186. doi:10.1016/j.shaw.2013.07.006
  39. Mousavisani SZ, Raoof JB, Ojani R, Bagheryan Z. An impedimetric biosensor for DNA damage detection and study of the protective effect of deferoxamine against DNA damage. Bioelectrochemistry. 2018;122:142-148. doi:10.1016/j.bioelechem.2018.03.012
  40. Mishra V, Rao S, D’Souza RN. Surface radiation dose measurement with MOSFETs for head and neck cancer using phantom. Cancer Therapy Oncol Int J. 2021;18(2):555984.
  41. Mendiratta N, Tripathi SL, Padmanaban S, Hossain E. Design and Analysis of Heavily Doped n+ Pocket Asymmetrical Junction-Less Double Gate MOSFET for Biomedical Applications. Applied Sciences. 2020;10(7):2499. doi:10.3390/app10072499
  42. Islam MT, Uddin MA. Biosensors, the emerging tools in the identification and detection of cancer markers. J Gynecol Women’s Health. 2017;5(4):555667.
  43. Bhatt AN, Mathur R, Farooque A, Verma A Dwarakanath BS. Cancer biomarkers; current perspective. Indian J Med. Research. 2010;132:129–149
  44. American cancer society; breast Cancer Facts & Figures. 2017-2018; №. 861017. GA 30303-1002
  45. Arab Hassani F, Shi Q, Wen F, He T, Haroun A, Yang Y, et al. Smart materials for smart healthcare– moving from sensors and actuators to self-sustained nanoenergy nanosystems. Smart Materials in Medicine. 2020;1:92-124. doi:10.1016/j.smaim.2020.07.005
  46. Fadeyev FA, Blyakhman FA, Safronov AP, Melnikov GY, Nikanorova AD, Novoselova IP, et al. Biological Impact of γ-Fe2O3 Magnetic Nanoparticles Obtained by Laser Target Evaporation: Focus on Magnetic Biosensor Applications. Biosensors. 2022;12(8):627. doi:10.3390/bios12080627
Support