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138 articles for “dose”
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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IoT-Based Automated Medication Management System
Abstract: An Internet of Things (IoT)-based automated medication dispenser with an integrated alert system is presented in this research. The device is managed by an ESP32 microcontroller, which is paired with a Real-Time Clock (RTC) module to ensure medication is dispensed at the correct time. To facilitate the dispensing process, the system uses servo and stepper motors to rotate the medication carousel and release the appropriate dosage. To determine whether the …
Published in International Journal of Solid State Innovations & Research · Vol. 3, Issue 1, 2025 · pp. 16–21 Read article
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Advancements in Photocatalysis: Applications in Environmental Remediation
Abstract: The study of radioluminescence, a phenomenon where materials emit light upon exposure to ionizing radiation, has expanded significantly in recent years, finding applications in various fields, including environmental remediation, radiation detection, and dosimetry. This paper reviews recent advancements in radioluminescent technologies, particularly focusing on Radioluminescent Isotope Cells (RLICs) and semiconductor colloidal quantum dots (cQDs). The use of RLICs, particularly those based on 63Ni, demonstrates enhanced energy conversion efficiency through optimized …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 2, 2024 · pp. 39–44 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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A Study on the Impact of Paracetamol on Male Reproductive System: A Mini Review
Abstract: Paracetamol, a widely used analgesic and antipyretic, has been studied for its potential effects on the male reproductive system. Paracetamol is a medication commonly used to relieve mild to moderate pain. Research suggests that prolonged or high-dose use of paracetamol may adversely affect male fertility by disrupting hormone regulation, impairing sperm production, and reducing testosterone levels. Studies have shown that paracetamol can interfere with the hypothalamic-pituitary-gonadal axis, leading to changes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 43–51 Read article
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Physical and Mechanical Properties of GGBS Based Geopolymer Concrete with the Inclusion of Metakaolin
Abstract: The use of ecologically friendly materials in the production of concrete is a significant and pertinent development in the global movement for sustainable construction. Geopolymer concrete (GPC) has gained popularity as an alternative to conventional Portland cement (OPC)-based concrete due to its utilisation of ground granulated blast furnace slag (GGBS), fly ash, and metakaolin, among other industrial by-products. The production of geopolymer concrete addresses serious environmental problems and contributes to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 261–266 Read article
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The Role of Gut Microbiota in the Health Effects of Fermented Dairy Products
Abstract: The human gut microbiota plays a crucial role in maintaining physiological health, influencing digestion, metabolism, immune function, and even mental well-being. Among dietary interventions aimed at modulating gut microbiota, fermented dairy products have emerged as particularly promising due to their rich content of live microorganisms, bioactive compounds, and nutrients. This review explores the intricate interactions between fermented dairy products and the gut microbiota, highlighting their potential health benefits and underlying …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 2, 2025 · pp. 5–10 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Advancements in Polymer Chemistry for Biomedical Applications: A Focus on Injection Guides
Abstract: Polymers have revolutionized biomedical applications, offering versatility, biocompatibility, and cost-effective manufacturing. This paper explores the role of polymer chemistry in the development of an advanced injection guide for precise drug delivery, aiming to enhance both safety and efficiency in clinical settings. Emphasis is placed on polymer selection, structural design, and functional modifications to improve injection procedures. By leveraging biodegradable and biocompatible polymers, the guide minimizes adverse tissue reactions while ensuring …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 129–136 Read article
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4D Printing in Drug Delivery: Application of Shape- Morphing Materials in Controlled Drug Release
Abstract: Four-dimensional printing technology has transformed the pharmaceutical landscape, offering unprecedented opportunities for innovation in drug development and delivery. This emerging technology enables the creation of complex geometries and customized structures, facilitating the design of personalized medications tailored to individual patient needs. Personalized dosing and drug release profiles, customized pill shapes and sizes for improved swallowability. Enhanced drug solubility and bioavailability, rapid prototyping and testing of pharmaceutical products. Development of complex …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 08–16 Read article
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Vaccines in the Fight Against COVID-19: Mechanisms, Efficacy, and Global Challenges
Abstract: The SARS-CoV-2 pandemic has created an unparalleled public health problem, necessitating comprehensive prevention. This page discusses COVID-19's evolution, scientific understanding, and quick vaccine production and implementation. It compares the mechanisms, efficacy, and safety profiles of the four major types of COVID-19 vaccines—namely mRNA, viral vector, protein subunit, and inactivated virus vaccines. Each type is evaluated in terms of how it stimulates the immune response, its effectiveness in preventing infection or …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 34–48 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Controlled Release Drug Delivery Using 3D Printing Techniques: A Current Scenario In Personalized Medicine
Abstract: Three-dimensional (3D) printing is particularly influencing the pharmaceutical manufacturing sector in the creation of controlled release drug delivery systems. This technology enables the precise fabrication of personalized medicines with tailored drug release profiles, dosages, and geometries, marking a significant advancement over traditional mass production methods. An array of 3D printing techniques, including extrusion-based, powder-based, and others, can be used to build complex dosage forms that regulate drug release through processes …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 28–43 Read article
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Chewable Healthcare: The Rising Impact of Gummy Supplements in Modern Medicine
Abstract: Gummy supplements, a chewable dosage form historically associated with pediatric vitamin products, are increasingly recognized as a versatile platform for delivering a wide range of nutraceutical and pharmaceutical agents. Their consumer appeal lies in their palatability, convenience, and the ability to overcome swallowing difficulties—a significant barrier to adherence in multiple patient populations. Recent advances in formulation science have expanded the potential of gummy supplements beyond basic vitamin delivery to include …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 52–68 Read article
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Homeopathic Posology: Principles and Practice
Abstract: The cornerstone of homeopathy lies in the principle of individualized therapy, and this concept is equally significant in determining the posology of homeopathic medicines. Unlike conventional medicine, where dosage is often standardized, homeopathic posology is carefully adapted to the specific condition and overall state of the patient. The primary source of guidance for homeopathic prescribing is Hahnemann’s Organon of Medicine, a seminal work published in six successive editions, each reflecting …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 45–51 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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Mycotoxins in Grains: Toxicological Impact, Detection Strategies, and Public Health Implications
Abstract: Many types of fungi create mycotoxins, which contaminate cereal grains like wheat, maize, rice, and barley. Even at low doses, aflatoxins, ochratoxins, fumonisins, and deoxynivalenol are harmful to humans and animals. This study covers mycotoxin occurrence, detection, toxicological consequences, and public health concerns in grain-based food systems. Advanced analytical methods, like LC–MS, ELISA, and biosensors, are discussed for their sensitivity and routine monitoring applications. Experimental and epidemiological studies analyze chronic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 8–18 Read article
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Agronomic Performance, Harvest Dynamics, and Oil Yield of Lemongrass Varieties in a Semi‐Arid Ecosystem: Effects of NPK Regime and Harvest Timing
Abstract: This study investigated the agronomic performance, biomass production, and essential oil yield of three lemongrass (Cymbopogon spp.) varieties (CKP-25, Krishna & Pragati) under varying NPK fertilization regimes and harvest timings in a semi-arid ecosystem. A split-plot factorial design with four nutrient levels (Control, 50%, 100%, and 150% of the recommended NPK dose) and two harvest stages (90 and 180 days after planting, DAP) was implemented. Results revealed that both NPK …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 1, 2026 · pp. 8–21 Read article
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What Nurses Should Know About New Ways to Treat Muscle Pain
Abstract: Muscle discomfort is a common clinical concern that can significantly limit mobility, functional ability, and overall quality of life. Recent advancements in assessment and management strategies have enabled nurses to deliver more precise, evidence-based care for patients experiencing muscular pain. Emerging diagnostic approaches now include enhanced screening scales that offer greater sensitivity in identifying pain patterns, as well as digital monitoring tools that allow continuous evaluation of symptoms across care …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 12–17 Read article