Research and Reviews: A Journal of Toxicology Review Article
Mycotoxins in Grains: Toxicological Impact, Detection Strategies, and Public Health Implications
Abstract
Many types of fungi create mycotoxins, which contaminate cereal grains like wheat, maize, rice, and barley. Even at low doses, aflatoxins, ochratoxins, fumonisins, and deoxynivalenol are harmful to humans and animals. This study covers mycotoxin occurrence, detection, toxicological consequences, and public health concerns in grain-based food systems. Advanced analytical methods, like LC–MS, ELISA, and biosensors, are discussed for their sensitivity and routine monitoring applications. Experimental and epidemiological studies analyze chronic mycotoxin exposure’s hepatotoxicity, nephrotoxicity, immunosuppression, and carcinogenicity. Global agencies’ regulatory frameworks and safety restrictions are also examined, revealing differences and issues in underdeveloped countries. Finally, to decrease exposure and protect public health, the study stresses the need for coordinated mitigation solutions across the grain supply chain, including preharvest management, postharvest storage, and consumer education.
Keywords
References (26)
- Alshannaq A, Yu JH. Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food. International Journal of Environmental Research and Public Health. 2017;14(6):632. doi:10.3390/ijerph14060632
- Deligeorgakis C, Magro C, Skendi A, Gebrehiwot HH, Valdramidis V, Papageorgiou M. Fungal and Toxin Contaminants in Cereal Grains and Flours: Systematic Review and Meta-Analysis. Foods. 2023;12(23):4328. doi:10.3390/foods12234328
- Food and Agriculture Organization. Grain mycotoxins: Causes, prevention, and control. Rome: FAO; 2010 [cited 2025 Aug 29]. Available from: http://www.fao.org.
- Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Frontiers in Microbiology. 2017;07. doi:10.3389/fmicb.2016.02170
- Waliyar F, Reddy SV, Thakur RP. Effects of mycotoxins on cereals grain feed and fodder quality: CFC Technical Paper No. 34. In: Alternative uses of sorghum and pearl millet in Asia, ICRISAT Asia Centre, Patancheru; 2004.
- Kortei NK, Annan T, Kyei-Baffour V, Essuman EK, Okyere H, Tettey CO. Exposure and risk characterizations of ochratoxins A and aflatoxins through maize (Zea mays) consumed in different agro-ecological zones of Ghana. Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-02822-x
- Liu J, Applegate T. Zearalenone (ZEN) in Livestock and Poultry: Dose, Toxicokinetics, Toxicity and Estrogenicity. Toxins. 2020;12(6):377. doi:10.3390/toxins12060377
- Lou Y, Xu Q, Chen J, Yang S, Zhu Z, Chen D. Advancements in Sample Preparation Methods for the Chromatographic and Mass Spectrometric Determination of Zearalenone and Its Metabolites in Food: An Overview. Foods. 2023;12(19):3558. doi:10.3390/foods12193558
- Zhang C, Qu Z, Hou J, Yao Y. Contamination and Control of Mycotoxins in Grain and Oil Crops. Microorganisms. 2024;12(3):567. doi:10.3390/microorganisms12030567
- Ortiz R, Ban T, Ranajit Bandyopadhyay RB, Banziger M, Bergvinson D, Hell K, et al. CGIAR research-for-development program on mycotoxins. Mycotoxins: detection methods, management, public health and agricultural trade. 2008:413-422. doi:10.1079/9781845930820.0413
- Garcia-Cela E, Kiaitsi E, Sulyok M, Krska R, Medina A, Petit Damico I, et al. Influence of storage environment on maize grain: CO2 production, dry matter losses and aflatoxins contamination. Food Additives & Contaminants: Part A. 2019;36(1):175-185. doi:10.1080/19440049.2018.1556403
- Janik E, Niemcewicz M, Podgórski M, Ceremuga M, et al. Mycotoxin detection methods: Old and new. Toxins. 2021. Available from: https://www.ncbi.nlm.nih.gov.
- Limsuwan S. Mycotoxin analysis method development, evaluation, and application. 2011.
- Li R, Wen Y, Wang F, He P. Immunoassays and biosensors for mycotoxin detection in feeds and foods: Recent breakthroughs. J Anim Sci Biotechnol. 2021;12:108. doi:10.1186/s40104-021-00629-4.
- Awuchi CG, Ondari EN, Nwozo S, Odongo GA, Eseoghene IJ, Twinomuhwezi H, et al. Mycotoxins’ Toxicological Mechanisms Involving Humans, Livestock and Their Associated Health Concerns: A Review. Toxins. 2022;14(3):167. doi:10.3390/toxins14030167
- Ekwomadu T, Mwanza M, Musekiwa A. Mycotoxin-Linked Mutations and Cancer Risk: A Global Health Issue. International Journal of Environmental Research and Public Health. 2022;19(13):7754. doi:10.3390/ijerph19137754
- Adaku Chilaka C, Mally A. Mycotoxin Occurrence, Exposure and Health Implications in Infants and Young Children in Sub-Saharan Africa: A Review. Foods. 2020;9(11):1585. doi:10.3390/foods9111585
- Chatterjee S, Dhole A, Krishnan AA, Banerjee K. Mycotoxin Monitoring, Regulation and Analysis in India: A Success Story. Foods. 2023;12(4):705. doi:10.3390/foods12040705
- Imade F, Ankwasa EM, Geng H, Ullah S, Ahmad T, Wang G, et al. Updates on food and feed mycotoxin contamination and safety in Africa with special reference to Nigeria. Mycology. 2021;12(4):245-260. doi:10.1080/21501203.2021.1941371
- Muñoz K, Wagner M, Pauli F, Christ J, Reese G. Knowledge and behaviour to reduce mycotoxin dietary exposure at home among German university students. Toxins (Basel). 2021;13(11):760. doi:10.3390/toxins13110760.
- Karlovsky P, Suman M, Berthiller F, De Meester J, Eisenbrand G, Perrin I, et al. Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Research. 2016;32(4):179-205. doi:10.1007/s12550-016-0257-7
- Mesterhazy A. Food Safety Aspects of Breeding Maize to Multi-Resistance against the Major (Fusarium graminearum, F. verticillioides, Aspergillus flavus) and Minor Toxigenic Fungi (Fusarium spp.) as Well as to Toxin Accumulation, Trends, and Solutions—A Review. Journal of Fungi. 2024;10(1):40. doi:10.3390/jof10010040
- Schmidt M, Zannini E, Arendt E. Recent Advances in Physical Post-Harvest Treatments for Shelf-Life Extension of Cereal Crops. Foods. 2018;7(4):45. doi:10.3390/foods7040045
- Schmidt M, Zannini E, Arendt E. Recent Advances in Physical Post-Harvest Treatments for Shelf-Life Extension of Cereal Crops. Foods. 2018;7(4):45. doi:10.3390/foods7040045
- Omotayo OP, Omotayo AO, Mwanza M, Babalola OO. Prevalence of Mycotoxins and Their Consequences on Human Health. Toxicological Research. 2019;35(1):1-7. doi:10.5487/tr.2019.35.1.001
- Ali S, Freire L, Rezende V, Noman M, Ullah S, Abdullah, et al. Occurrence of Mycotoxins in Foods: Unraveling the Knowledge Gaps on Their Persistence in Food Production Systems. Foods. 2023;12(23):4314. doi:10.3390/foods12234314