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1969 articles for “quantum mechanics/molecular mechanics (QM/MM)” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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The Efficacy of Fig Extract on Some Candida spp.
Abstract: The study was conducted in Al-Amin Laboratory by preparing the alcoholic extract of fig leaves, which were collected from the garden of a house in Najaf Governorate / Al-Shuara’a during the month of December 2023 for the purpose of testing its inhibitory effectiveness against two isolates of the fungus Candida albicans and Candida dubliniesis taken from Al-Amin Scientific Research Laboratory, where serial concentrations of the extract were prepared (12,9,6,3) mg/ml., …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 19–23 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Utilization of Recron Fibers for Improving Subgrade Stability of Expansive Soils
Abstract: The major interest in the utilization of synthetic fibers is used as reinforcing material for developing reinforcing effect into the entire soil composition laid bellow the structures whare as construction works are going on. Various articles are published on soil reinforcement, yet some of them fibers used are prepared by using with synthetic materials, one type of synthetic fibers were Recron fiber it is used as a reinforcing element to …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 170–178 Read article
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Investigation on Dry Sliding Wear Behaviour of AlSi7Mg0.3/B4C/ZrO2 Hybrid Composites using Taguchi Method
Abstract: Hybrid Aluminium/Boron carbide/Zirconium oxide (AlSi7Mg0.3/B4C/ZrO2) composites were fabricated utilizing stir casting technique by varying boron carbide content (4wt.%, 8wt.% and 12wt.%) and utilizing a fixed amount (4wt.%) of zirconium oxide particles. Optical microscopy revealed that B4C and ZrO2 particulates were dispersed uniformly in AlSi7Mg0.3 matrix. Dry sliding wear experiments were carried out utilizing the pin-on-disc tribometer with various levels of applied loads, sliding speeds and weight percentage of boron carbide …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 166–177 Read article
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Analysis of C45 Steel Machining with Differentiated Tool Bits
Abstract: The tool material may be coated or uncoated, and cutting inserts are typically situated along the covered contact region. Work piece remains fixed while tool revolves for cutting and machining. Objective: A NABL-accredited metallurgical evaluation laboratory (machining) assessed two specimens. Machining profile and materials determine insert selection. Analytical results show material composition. The surface qualities of samples 1 and 2 were examined. As DOC, cutting speed and tool tip temperature …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 244–252 Read article
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Enhancing Smart Grid Security: Machine Learning Approaches for Detecting Anomalies
Abstract: The integration of Information and Communication Technology (ICT) with traditional electric grids has led to the development of smart grids. However, this integration has also increased the risk of anomalies, such as cyber-attacks, metering fraud, electricity theft etc. False Data Injection Attacks are a class of cyber-attacks against power grid monitoring systems, where adversaries can inject false data to manipulate the grid’s operation. Metering frauds pertain to malicious customers com- …
Published in Trends in Electrical Engineering · Vol. 14, Issue 2, 2024 · pp. 10–19 Read article
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Design and Implementation of an IoT-Based Power Theft Detection System Using Sensor Networks
Abstract: With the increasing demand for efficient energy distribution and consumption monitoring in smart grid systems, the need for robust power theft detection mechanisms becomes paramount. This project proposes an IoT-based solution utilizing energy metering to detect instances of power theft within different segments of the distribution network. The system employs three types of energy meters: Distribution Point (DP), Pole, and Domestic meters. Every meter is positioned thoughtfully to track the …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 2, 2024 Read article
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Sustainable Construction: A Case Study of Passive Cooling Using Various Insulation Materials in an Educational Institution
Abstract: This case study is about insulating an education building where steel sheets are used on the rooftop. Steel roof sheets are good conductors of heat and due to which the classrooms below become heated up especially in the summer season from January to May every year. This educational building was constructed in 2014 and the heat build-up is intense and hence the top floor i.e. second floor was mostly unutilised …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 14, Issue 2, 2024 · pp. 23–31 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Valeriana Jatamansi in Ailment of Various Diseases: A Review
Abstract: V. wallichii, often known as Valeriana jatamansi, is a significant medicinal herb. The word ‘Valerian’, which is derived from the word ‘Velo’ means ‘strong drug’, was originally used by an Indian doctor in the ninth century. This review focus on their geographical characterization, botanical characterization, traditional uses, and their mechanism of action on various bioactivity. This review discusses the major bioactive constituents and their 2D and 3D structures. V. jatamansi …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 1–13 Read article
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A Review Paper on Friction Stir Processing on Aluminium Alloys
Abstract: Friction stir processing is a step from friction stir welding, targeted at surface modification through improving the local microstructure via localized plastic deformation. The tool consists of a rotating mechanism incorporating a shoulder and pin that are inserted into the material, traversing the designated area. When the tool's shoulder and the workpiece make contact, friction develops, generating heat that produces plastic deformation. This localized plastic deformation and heat impact result …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Heterocyclic Substituted Flavones: Bridging Natural Products and Medicinal Chemistry
Abstract: Heterocyclic substituted flavones represent a unique and promising class of flavonoid derivatives, gaining significant attention in recent years due to their diverse and enhanced biological activities. These compounds are characterized by the incorporation of heterocyclic moieties such as quinoline, pyridine, thiazole, imidazole, oxazole, and pyrazole into the flavone structure, which significantly alters and often enhances their bioactive properties. This structural modification has made heterocyclic flavones particularly appealing as candidates for …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 23–30 Read article
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Design Optimization and Performance Analysis of Autonomous Drone Systems
Abstract: In recent years, drones have become indispensable tools across various industries, thanks to their versatility and wide-ranging applications. The fabrication of drones is a complex process that integrates multiple engineering disciplines, including mechanical design, electrical systems, aerodynamics, and software development. The meticulous design of the drone’s frame, taking into account factors such as weight, durability, and aerodynamic efficiency, marks the commencement of the fabrication process. The paper presented a comprehensive …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 21–30 Read article
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Direct Synthetic Routes of MXenes and Their Application in Carbon Fiber Reinforced Plastics (CFRPs) As Supplementary Sizing Layer†
Abstract: Sized carbon fibers with a supplementary sizing layer of MXenes (synthesized via traditional MAX phases), bonded to carbon fibers (CFs) as well as the resin matrix via different kinds of physicochemical (van der Waals force, hydrogen bonding, covalent bonding) interactions enhanced the performance of the resulting carbon fiber reinforced plastic (CFRP) materials. This is because of the strong interface generated due to the appearance of MXene at the interface of …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 07–13 Read article
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A Comprehensive Study of ZnxFe2-xO3 Nanoparticles: Assessing Magnetic Properties for Medical Imaging (MI)
Abstract: Diluted magnetic ZnxFe2-xO3 nanoparticles are special semiconducting nanoparticles which are recognized for their magnetic properties. A theoretical examination of Zn-doped αFe2O3 nanostructures reveals a range of structural and property variations, offering insights into their potential applications and behavior at the nanoscale. In this regard, Heisenberg’s model and Weiss molecular filed theory is used to describe the magnetic properties of ZnxFe2-xO3 nanoparticles. These theorems inevitably enable to investigate the relationship between …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 2, 2024 · pp. 18–25 Read article
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Synthesis, Characterization, and Reactivity of Bivalent Tin(II) with 4-Tert-butylphenol
Abstract: Bivalent tin(II)-4-tert. butylphenoxide of composition Sn(OC6H4X-4)2(I), where X = But, has been synthesized by the reaction of stannous chloride (SnCl2) with bimolar amounts of 4-tert. butyl phenol (HOC6H4But-4) in the presence of the base, diethyl amine, in tetrahydrofuran (THF) solvent. The resulting complex was characterized by elemental analysis, molecular weight determination, molar conductance measurement, IR, and 1H NMR spectral studies. The reactivity of the newly synthesized complex (I) with HgCl2 …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 14–19 Read article
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Magnetic ZnxFe2–xO3 Nanoparticles Enhanced Nanobiosensor Integrated with MOSFETs for Efficient Detections of Biomolecules and Cancerous Cells
Abstract: The human brain is mostly responsible for intelligence and consciousness. An artificial equivalence of this action is nanobiosensor, which is used in artificial intelligence. The need for nanodiagnostics platforms for detecting diseases at the genetic, molecular, and cellular level has triggered the development of nanobiosensors integrated with MOSFETs. This device enables simple, inexpensive rapid tests, accurate imaging methods, and accurate molecular diagnosis at point-of-care (POC). This device is seen as …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 3, 2024 · pp. 33–44 Read article
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Prevention of Primary Hypertension Through Asbab-e-Sitta Zaruriya: A Therapeutic Paradigm
Abstract: Hypertension, defined as blood pressure elevation to a level that increases the risk of organ damage, Recent guidelines classify hypertension as systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥80 mmHg, distinguishing between primary (essential) and secondary forms. It affects over one billion individuals globally and contributes to approximately 9.4 million deaths annually. Nearly 63% of total deaths in India are due to non-communicable diseases, of which 27% are …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2024 · pp. 13–20 Read article