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216 articles for “Insulin/IGF1-AKT-mTOR”
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Evaluation of Jackfruit (Artocarpus heterophyllus Lam.) Germplasm
Abstract: AbstractThe experiment was conducted with the existing bearing trees of different jackfruit genotypes at Jamalpur region during the year 2014–2015. Twenty-three jackfruit germplasm viz., AHJ-01, AHJ-02, AHJ-03, AHJ-04, AHJ-05, AHJ-06, AHJ-07, AHJ-08, AHJ-09, AHJ-10, AHJ-11, AHJ-12, AHJ-13, AHJ-14, AHJ-15, AHJ-16, AHJ-17, AHJ-18, AHJ-19, AHJ-20, AHJ-21, AHJ-22 and AHJ-23 were selected for the study to identify superior ones. The recorded age of the selected tress ranged from 8 to 29 years. …
Published in Research & Reviews : Journal of Botany · Vol. 7, Issue 1, 2018 · pp. 38–53 Read article
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Study on Contamination, Source and Microbial Quality of Selected Street Fruit Juices and Sherbet in Tangail City
Abstract: Fruit juice and sherbet are popular refreshing drinks with great taste and health benefits. These are available in most of the public places at reasonable prices which are consumed by road side customers of all ages. Lack of good manufacturing practices, nutritionally rich component of juices makes the product good medium for microbial growth. Water used for juice preparation can be a major source of microbial contamination. Argued this point, …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 7, Issue 1, 2018 · pp. 1–8 Read article
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Documentation of Leaf Curl Virus Resistance Sources in BARI Released Tomato Varieties and Lines
Abstract: An experiment was conducted at the Regional Agricultural Research Station, Jamalpur, Bangladesh during rabi season of 2022-23 to identify noble sources of resistance in BARI released Tomato varieties/lines against leaf curl viruses. The evaluation of forty-six Tomato genotypes was performed against Tomato Leaf Curl Viruses (ToLCV) under natural conditions where the viruses were transmitted by white fly. However, ToLCV-infected plants ranged from 6.25 to 39.58% in the study. Thirty-four varieties/lines …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 13, Issue 3, 2023 · pp. 64–79 Read article
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Factor Analysis of Crime Data
Abstract: Crime analysis is an act implementation function that includes organized investigation for increasing clarifications to crime problems, and articulating crime stoppage outlines. The main part of crime analysis process is the quantitative social science data analysis methods, though qualitative methods for instance inspecting police report tales also performance a character. This paper analyses US crime data by applying multivariate factor analysis techniques that was engaged to describe the association between …
Published in Research & Reviews : Journal of Statistics · Vol. 9, Issue 2, 2020 · pp. 20–32 Read article
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A Novel Clustering Techniques Evaluation using Monte Carlo Simulation
Abstract: In Machine Learning clustering is one the most significant method. Today, we have data in rich from many sources but in order to get meaningful information from it is very boring task. Machine learning clustering algorithms to create cluster to decode the meaningful information from the data, this analysis approach has gained much popularity in recent years. This paper explores evaluation performance of frequently used existing clustering techniques such as …
Published in Research & Reviews : Journal of Statistics · Vol. 10, Issue 3, 2021 · pp. 1–23 Read article
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Parametric Quantile Regression using Quantile-based Asymmetric Family of the Distributions
Abstract: Quantile regression is used for finding the effects of covariates on different quantiles of the response variable. The contribution of this article is to develop a theory of quantile regression using the Quantile-based asymmetric (QBA) family (similar to GAMLSS for mean regression) and then apply the proposed approach for analyzing COVID-19 data. More precisely, we estimate regression quantiles and investigate the asymptotic estimators under a generalized linear modeling framework, but …
Published in Research & Reviews : Journal of Statistics · Vol. 11, Issue 3, 2022 · pp. 54–66 Read article
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Nutrient-Mediated Activation of Cellular Signaling Pathways: Mechanistic Insights into Attenuation of Toxin Induced Inflammation in Food Animals
Abstract: Dietary and environmental toxins remain a persistent challenge in food animal production, where subclinical and clinical inflammation compromises health, productivity, and food safety. Toxin induced inflammation is driven by oxidative stress, mitochondrial dysfunction, and dysregulated immune signaling, resulting in impaired metabolic efficiency and increased disease susceptibility. Recent advances in nutritional science have revealed that nutrients act not only as substrates for growth but also as signaling molecules capable of modulating …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 1–12 Read article
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Metabolic Syndrome in Psoriatic Patients: A Cross-Sectional Study
Abstract: Background: Psoriasis is a chronic immuno-inflammatory disease affecting the skin and joints. Studies have demonstrated an increased prevalence of conventional cardiovascular risk factors such as diabetes mellitus, hypertension, and metabolic syndrome in these patients. The aim of this study was to determine the association between psoriasis and metabolic syndrome. Material and Method: An observational cross-sectional study was carried out between November 2023 and October 2024, including participants with and without …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 17–23 Read article
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A Pre-experimental Study to Assess the Effectiveness of Buerger Allen Exercises on Improving the Peripheral Blood Circulation among the Diabetic Patients Admitted at GGS Medical Hospital, Faridkot
Abstract: Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar because thepancreas does not produce enough insulin or cells do not respond to insulin. The high blood sugarproduces classical symptoms of polyuria, polydipsia and polyphagia. Type 2 diabetes mellitus is non-insulin dependent in which there is an absolute insulin deficiency due to destruction of islets cell in thepancreas. Type 2 diabetes mellitus makes up …
Published in Journal of Nursing Science & Practice · Vol. 11, Issue 2, 2021 · pp. 35–42 Read article
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Prevalence of Oral Mucosa Lesions in Smoking, Non-Smoking, Diabetic Patients with Smoking and Diabetic Patients without Smoking
Abstract: Tobacco smoking habit is a risk factor for many oral lesions. A positive association between cigarette smoking and acute necrotizing ulcerative gingivitis (ANUG) was first reported over four decades ago. The dental loss was noted more in smokers than non-smokers. The periodontal disease is noted more in smokers and results alteration in the gingival indexes (GI) and gingival bleeding (GBI) indexes in smokers. Many studies revealed that a strong an …
Published in Research and Reviews: A Journal of Dentistry · Vol. 11, Issue 3, 2020 · pp. 14–17 Read article
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β-cell Deficit Due to Increased Apoptosis Islet Cell Plasticity in Humans Type 2 Diabetes
Abstract: Beta cells (β cells) in the pancreatic islets produces insulin and the number of functional insulin-producing β-cell contributes to the pathophysiology of type 2 diabetes . Type 2 diabetes is a chronic disease characterized by the deficiency in β-cells and increase in the levels of sugar in blood. β cells promote inflammation in obesity and type 2 diabetes. The low β-cell accumulation in Type 2 diabetes paves way to diabetes …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 1, 2021 · pp. 1–7 Read article
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Limitations to Therapeutic Approaches to T2DM in Light of Different HbA1C Values Suggested by Different Scientific Associations: A Review
Abstract: The present article provided a comprehensive review of international and national guidelines for managing Type-2 diabetes, with a focus on personalized treatment strategies. It discussed the recommended glycated haemoglobin targets and the initial treatment approach involving lifestyle modifications and the use of metformin. The present article underlined the necessity for treatment intensification due to the progressive nature of type-2 diabetes. It also emphasized the complexity of selecting additional antidiabetic medications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 13–26 Read article
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An Evaluation of Letrozole and Clomiphene Citrate Efficacy as Ovulation Induction Medication in Females with Polycystic Ovarian Condition
Abstract: Polycystic ovarian condition is the most common endocrinopathy in anovulatory infertile females. As a long-established conventional treatment for ovulation induction, clomifene citrate (also known as clomiphene) is still recommended to PCOS patients as their first line of treatment. Indian PCOS women are more prone to have high levels of clomiphene resistance due to the high frequency of insulin resistance . While letrozole has a high potential for ovulation induction, it …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 2, 2024 · pp. 23–29 Read article
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A review on the effects of Indian medicinal spices on age related molecular and cellular pathways in light of geriatric muscle loss
Abstract: Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 3, 2024 · pp. 1–10 Read article
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Indian Medicinal Plants used in Diabetes Mellitus: An Overview
Abstract: Diabetes mellitus (DM) is the commonest endocrine disorder that affects more than 100 million people worldwide (6% of the population). It is caused by the deficiency or ineffective production of insulin by pancreas which results in increase or decrease in concentrations of glucose in the blood. It is found to damage many of the body systems, particularly the blood vessels and nerves both insulin-dependent DM (IDDM) and non-insulin dependent DM …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 1, 2017 · pp. 1–10 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 62–73 Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 69–76 Read article
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Concept of Type-2 Diabetes mellitus (Ziabetus shakri) in Unani System of Medicine
Abstract: The term diabetes mellitus (DM) describes a metabolic disorder of multiple aetiology, characterized by chronic hyperglycaemia with disturbance of carbohydrate, fat and protein metabolism; resulting from defects in insulin secretion, insulin action, or both. If the disease condition is left untreated, it causes many complications. It currently affects more than 62 million Indians, which is more than 7.1% of the adult population. Nearly 1 million Indians die due to diabetes …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2020 · pp. 22–25 Read article
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Production, Estimation and Protein Network Studies of Bioethanol Fermented Media from Maduca Longifolia Produced by Surface Fermentation using Candida Albicans
Abstract: Candida albicans is a fungus that is used as industrially important species in fermentation productions from past several decades. In the present experimentation, Madhuca longifolia dried flowers with Candida albicans, Saccharomyces cerevisiae, and Pseudomonas aeruginosa respectively are used as cultures and was analyzed for bioethanol production. Bioethanol produced in M. longifolia+yeast with about 40% was more compared with other samples. M. longifolia+ Pseudomonas showed 20% ethanol, M. longifolia+ candida 14% …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 1, 2018 · pp. 9–14 Read article