Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. Large part of the preclinical and clinical investigations on medicinal benefits of spices are centered around their phytochemical compounds such as thymoquinone, thymol, diosgenin, 4-hydroxyisoleucine, furostanolic etc in terms of associated mechanistic pathways modulated and their cellular and physiological benefits. In this review, we perform a systematic study of evidence-based phytochemicals from the enlisted spices that can exert a positive impact on aging related molecular and cellular functions. In the end we also summarize their implications on preserving age-related muscle mass in terms of their anti-inflammatory, anti-diabetic, anti-oxidant, muscle regeneration capacity and anti-fatigue action.
