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142 articles for “Inhibitory”
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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Study of the Antibacterial Activity of Artemisia Absinthium against E. coli bacteria Isolated from Urinary Tract Infections
Abstract: Twenty clinically diagnosed samples were collected using transport medium swabs from the operating room at Al-Amal Specialized Laboratory in Iraq between November 2025 and February 10, 2026. Antibiotic susceptibility testing was performed on the 20 Escherichia coli samples. The results showed a clear difference in the bacterial isolates' response to the tested antibiotics. Imipenem demonstrated the highest inhibition rate, reaching 24.55% (100%), compared to the other antibiotics used in the …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 17–25 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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Synergistic biofuel production, refractometric monitoring and trypsin digestion studies from Clitoria ternatea, Cymbopogon citrates and Saccharomyces cerevisiae
Abstract: The rising demand for renewable and green energy sources has encouraged researchers to seek sustainable alternatives to fossil fuels. In the present study, an investigation was conducted on the synergistic production of biofuel from plant materials of Clitoria ternatea and Cymbopogon citratus with microbial fermentation by Saccharomyces cerevisiae. The study also evaluated the refractometric monitoring and trypsin digestion activity for the understanding of biochemical changes during biofuel production. The oil …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 11–22 Read article
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Copper Sulfide Semiconducting Nanoparticles for Antibacterial Applications: Synthesis Strategies, Mechanisms and Performance – A Review
Abstract: Copper sulfide nanoparticles (CuS NPs) have drawn growing attention as a next-generation antibacterial platform, owing to their tunable structural, optical, and catalytic properties. This review consolidates current evidence on CuS NP synthesis, mechanisms, and antibacterial performance, comparing chemical and green synthesis routes alongside the effects of morphology, doping, and surface modification. Mechanistically, CuS NPs act through several overlapping pathways, including reactive oxygen species generation, bacterial membrane disruption, ion release, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 236–253 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Hexavalent Chromium Resistance Test of Saccharomyces Cerevisiae and Modeling of its Bioaccumulation Process
Abstract: Now a day, the release of high chromium containing tannery waste water from tanning industries to the environment is the life threatening action of human activities and bioaccumulation becomes a better alternative in treating heavy metals(such as Cr(VI) )due to its cost effective, relatively high heavy metal removal capacity and recovery property. Cell suspensions of S.cerevisiae at its exponential growth phase were added to 250 ml plastic flasks of containing …
Published in Emerging Trends in Chemical Engineering · Vol. 8, Issue 1, 2021 · pp. 36–44 Read article
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A Scientific Study: Regulation of Autonomic Nervous System through Slow Breath Pranayama
Abstract: Voluntary slow deep breathing functionally resets autonomic nervous system through stretch induced inhibitory signals and hyper-polarization currents that propagate through both, neural and non-neural tissue. The scientific basis of benefits of practicing slow Pranayama, especially alternate nostril breathing (Nadi Shodhana Pranayama as NSP) and Dhyana is regulation of cerebral dominance and shifting of autonomic nervous system. This regulation occurs via Nadisunder control of Agya Chakra. The aim of the present …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 5, Issue 3, 2016 · pp. 23–28 Read article
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Treatment of Migraine with Aura (Ardhavabhedaka) by Nasya and Shanshaman Chikitsa: A Case Study
Abstract: The most popular and efficient system of allopathic medicine provides quick response for the pain and other symptoms, but does not provide the complete treatment. My focus is the study of headache/migraine (ardhavabhedaka) with alternative line of treatment such as Ayurveda, because this stream is complete and provides holistic approach. A 42 year old male patient having complaints of recurrent severe headache and vomiting since 15 years, and diagnosis was …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 6, Issue 2, 2017 · pp. 12–15 Read article
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Analytical and in Vitro Evaluation of Krimighna Karma of Padumale, A Folklore Plant–Lindernia Crustacea (L) F. Muell W.S.R. To Diarrheagenic Organisms
Abstract: Traditional knowledge of medicinal plants got more importance in recent era. Hence there is a need to develop new effective traditional drugs with scientific validation. One such plant is Lindernia crustacea (L) F. Muell called as padumale in south canara district, Karnataka. It is small slender prostrate plant found in moist shady places. The local people successfully use the juice of fresh plant in few drops once in a day …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 9, Issue 03, 2022 · pp. 1–11 Read article
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Soursop Phytocompounds as Potential Anticancer Agents: A Molecular Docking Study
Abstract: Objective: According to tumor statistics, there will be a total of approximately 1,958,310 new malignancy cases, that balances to nearly 5,370 cases day by day. Without any questions its clearly evident that cancer is considered as one of the deadliest diseases of mankind. The course of this study emphasizes on computational approach for finding new drug for potential target proteins Bcl-2 (4MAN) and Mcl-1(5FDO) by docking against soursop (Annona Muricata …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 18–39 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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Hematopoietic stem progenitor cells reduce the proliferation of Tregs via regulation of IL-12/STAT4 signaling during chronic stress
Abstract: Abstract. Physical or psychological chronic stress mediates the impaired immune response by inducing the proliferation of regulatory T cells (Tregs). Our recent studies showed that hematopoietic stem progenitor cells (HSPCs) significantly modulated the immune system. HSPCs prevented stress-induced lymphocyte apoptosis, exerting a protective effect in chronic stress-induced immune responses. Thus, whether HSPCs could prevent the proliferation of Tregs in conditions of chronic stress was assessed in the present study. Injection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 3, 2022 · pp. 1–10 Read article
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Evaluation of Antimicrobial Activity of Some Medicinal Plants against Most Prevalent Diabetic Wound Pathogens
Abstract: The present research work attempts to evaluate antimicrobial activity of 90% ethanolic extracts of three traditional medicinal plants viz. Terminalia bellirica, Terminalia chebula, Pyhllanthus emblica. Since ethanol is the best solvent for dissolving antimicrobial compound present as active phytoconstituents in plants, these plants were extracted with ethanol. Each extract was tested for its antimicrobial activity against three most prevalent pathogenic microorganism associated with diabetic wounds, viz. Staphylococcus aureus (MTCC3160), Pseudomonas …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 1, 2015 · pp. 13–20 Read article
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Colorimetric Redox Indicator assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region
Abstract: Tuberculosis (TB) has affected humans since antiquity. The burden of TB particularly with multi-drug-resistance (MDR) is increasing worldwide and has become a major public health concern. This study aims to perform Colorimetric Redox Indicator (CRI) assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region. Total 234 samples were collected from South Gujarat region and were subjected for microscopy examination, culturing on Lowenstein-Jensen (LJ) medium and drug susceptibility …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 65–70 Read article
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Determination of antimicrobial potential of Bacillus clausii against Candida albicans
Abstract: Bacillus clausii is a universally occurring beneficial bacteria.It is gram-positive, spore forming, lactic acid producing probiotic. Bacillus clausii are support the growth of friendly bacteria and help maintain a healthy balance of microflora in the intestinal environment. A study was carried out on inhibitory effects of Bacillus clausii on growth of some pathogens isolated from clinical specimens of pathogens selected for this study were Candida albicans isolated from blood and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 10, Issue 1, 2020 · pp. 1–4 Read article
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Antibacterial Action of Bacillus coagulans Against Diverse Pathogens and its Relevance as Probiotics
Abstract: Probiotics are living organisms that give benefits to the host organism by improving the intestinal microbial balance. Probiotics have various beneficial effects as it maintains a healthy gut, healthy vaginal flora and boost the immune system. There are different strains of lactic acid bacteria that are used as probiotics but Bacillus coagulans is a good bacterium that is used in the form of probiotic supplements. In the present study, B. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 2, 2023 · pp. 21–25 Read article
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Isolation of Lactobacillus Acidophilus with A High Acid-Producing Capacity and Its Common Characteristics
Abstract: Some strains of lactobacilli like spore Lactobacillus offer good merits in normalizing intestinal micro biota, resisting selectively to intestinal pathogens, exerting resistance to heat, acid and antibiotics, and are of good storage stability. This research work has been conducted in order to isolate a certain strain of Lactobacillus that offers high resistance to the gastric acid, bile and pathogens, and mutualistic symbiosis with useful intestinal microbes, and identifying its characteristics …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 1–6 Read article
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Effect of Transcranial Direct Current Stimulation (tDCS) in Somatosensory Evoked Potential (SSEP) in Normal Adolescents
Abstract: tDCS is a noninvasive brain stimulation technique in which a mild electrical direct current is applied through the scalp to send electrical impulses to the brain to increase or decrease the excitability in the neurons. Weak transcranial direct current stimulation can induce long lasting changes in cortical excitability. The electrodiagnostic approaches like Motor Evoked Potentials (MEP), Somato Sensory Evoked Potential (SSEP) and electromyography are used to measure the effect of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 3, Issue 2, 2013 · pp. 1–8 Read article
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Thrombotic thrombocytopenic purpura: A Narrative Review of Diagnosis and Treatment by drugs and novel agents.
Abstract: Thrombotic thrombocytopenic purpura (TTP) is an infrequent but fatal disease, is primarily caused by autoantibodies against the von Willebrand factor (VWF) cleaving metalloprotease ADAMTS13. Overall, severe deficiency of plasma ADAMTS13 action (< 10 IU dL-1) with or without noticeable inhibitory autoantibodies counter to ADAMTS13 supports the diagnosis of TTP. The International Working Group for TTP released a consensus statement on the standardization of terminology in these disorders which we use …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 1, 2021 · pp. 40–55 Read article