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116 articles for “variants”
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CNN-Based Wound Segmentation: A Review of Models and Performance Evaluation
Abstract: Deep learning, particularly convolutional neural networks (CNNs), has altered medical image processing by automating and precisely segmenting complex medical pictures. Wound segmentation, a critical application in automated wound assessment, is essential for wound size estimation, classification, and healing progress monitoring. This study presents a comprehensive review of CNN-based wound segmentation models, focusing on their architectures, methodologies, and performance on diverse datasets. Four deep learning models, including two U-Net variants (5-layer …
Published in Current Trends in Signal Processing · Vol. 15, Issue 1, 2025 · pp. 33–46 Read article
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Solid Lipid Nanoparticles in Medicine: Formulation, Characterization and Future prospects
Abstract: An alternative to conventional colloidal carriers such liposomes, polymeric nanoparticles, and emulsions, solid lipid nanoparticles (SLNs) were created in the early 1990s. Benefits include targeted medicine distribution, controlled drug release, and improved stability. An extensive review of the excipients utilized, the production techniques, including the membrane contractor approach, and the possible advantages and disadvantages of SLNs is given in this work. It investigates secondary stabilization techniques like freeze-drying and spray-drying, …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 1–15 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Bal Ex Module with Prayer Regimes Improves Standing Dynamic Balance of balance disorders cases
Abstract: Integrating prayer regimes into balance rehabilitation, a well-established approach for patients with balance disorders offers an intriguing dimension to the therapy that had been incorporated in this Bal Ex Homebased video module for balance rehabilitation. Vestibular rehabilitation, often exemplified by Cawthorne-Cooksey exercises and their customized variants, effectively addresses symptoms like vertigo and instability. However, it's important to approach the inclusion of spiritual practices with sensitivity, acknowledging patients' diverse beliefs and …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 10–14 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Erythrodermic Psoriasis: A Case Report Highlighting Clinical Features and Management
Abstract: Background: Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis that presents as widespread erythema, scaling, and systemic complications such as fever, dehydration, and electrolyte imbalances. It requires urgent medical attention due to the risk of life-threatening complications, including sepsis and multi-organ failure. The condition can arise de novo or as an exacerbation of pre-existing psoriasis, often triggered by medication withdrawal, infections, or systemic inflammation. Case Presentation: We …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 01–05 Read article
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Blood Cell Saver Machine
Abstract: Intraoperative Cell Salvage (ICS) is a crucial technique in modern surgical practice aimed at minimizing the need for allogeneic blood transfusions. By collecting, filtering, washing, and re-infusing a patient’s own blood lost during surgery, ICS provides a safer and cost-effective alternative to donor transfusion, reducing the risk of transfusion-related infections and immunologic reactions. Initially conceptualized in the early 19th century, ICS technology evolved significantly with the introduction of the Cell …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 51–59 Read article
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Advancing Brain Tumor MRI Segmentation
Abstract: Segmentation of brain tumors in MRI scans is an integral part of neuroimaging carried out for diagnostic and therapeutic interventions. Given that manual segmentation is cumbersome and highly variable, there arises a need for automated, more precise segmentation solutions. This project, ‘Machine Learning and Deep Neural Networks to Advance Brain Tumor MRI Segmentation’ will develop a better, efficient, and accurate segmentation model to help clinicians identify brain tumors with greater …
Published in Recent Trends in Electronics Communication Systems · Vol. 12, Issue 2, 2025 · pp. 28–33 Read article
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Polymer Chemistry in Biomedical Applications: Advances and Innovations
Abstract: Polymers have revolutionized biomedical sciences by playing a crucial role in medical devices, drug delivery systems, and tissue engineering. It is important to note that their unique combination of biocompatibility, mechanical strength, and chemical versatility makes them essential for applications such as implants, prosthetics, and diagnostic tools. Biomedical polymers are categorized into natural types (e.g., collagen, chitosan) and synthetic variants (e.g., polyethylene glycol, polylactic acid), each offering distinct benefits depending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Study on Partial Replacement of Cement with Pinus Fiber and Nano Silica in M30 Concrete Paver Blocks: A Fiber-Reinforced Polymer-Cement Composite Approach
Abstract: This study investigates the partial replacement of cement in M30 grade concrete paver blocks using nano silica and Pinus fiber, with a primary focus on mechanical performance, sustainability, and long-term durability and promoting sustainability. Portland cement, a major contributor to global CO₂ emissions, can be partially substituted using supplementary materials to create eco-efficient construction solutions. Nano silica, due to its high pozzolanic reactivity and ultrafine size, improves the microstructure and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 63–76 Read article
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Vaccines in the Fight Against COVID-19: Mechanisms, Efficacy, and Global Challenges
Abstract: The SARS-CoV-2 pandemic has created an unparalleled public health problem, necessitating comprehensive prevention. This page discusses COVID-19's evolution, scientific understanding, and quick vaccine production and implementation. It compares the mechanisms, efficacy, and safety profiles of the four major types of COVID-19 vaccines—namely mRNA, viral vector, protein subunit, and inactivated virus vaccines. Each type is evaluated in terms of how it stimulates the immune response, its effectiveness in preventing infection or …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 34–48 Read article
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Critical Review of Impact of UNIX in Development of Military Computing Paradigms
Abstract: The evolution of military computing systems has been profoundly influenced by the integration and continuous advancement of UNIX operating systems since their inception in the early 1970s. This paper presents a comprehensive review of the pivotal role UNIX has played in shaping the foundational architecture of modern military computing—spanning areas such as command-and-control infrastructures, real-time data processing, mission-critical software, and cybersecurity protocols. By tracing the historical development and technical progression …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 2, 2025 · pp. 08–16 Read article
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Optimizing Mechanical and Durability Properties of Eco-Friendly Composite Materials Using Recycled Fillers and ML Techniques
Abstract: The increasing demand for sustainable construction materials has intensified the exploration of recycled fillers as partial or full replacements for natural aggregates in composite materials. This study investigates the mechanical and durability performance of polymer matrix composites incorporating processed recycled fillers derived from construction and demolition (C&D) waste. Three distinct processing methods were employed to prepare the recycled fillers: untreated (URF), single processed (SPRF), and double processed (DPRF), with replacement …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 269–309 Read article
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Examining the Relationship Between Academic Stress, Maladaptive Perfectionism and Trauma-Related Responses Among University Students
Abstract: Academic stress is a significant concern among university students, frequently contributing to maladaptive perfectionism and trauma-like responses. While perfectionism can enhance performance, its maladaptive variant may be exacerbated by academic stress which can induce trauma-like responses. This study investigates the correlation between academic stress, maladaptive perfectionism and trauma-like responses. Validated self-report measures were used in a quantitative, correlational study involving 101 university students. Linear regression analysis and Kendall’s Tau-B correlation …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 145–154 Read article
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Targeting Papain-Like Protease of Re-Emerging Coronaviruses
Abstract: Re-emerging Corona viruses (CoVs), including SARS-CoV (S-CoVs), and SARS-CoV-2 (S-CoV-2), continue to pose a global health threat due to their high mutation rates, zoonotic spillover potential, and capacity for immune evasion. The global pandemic of year 2019, caused by S-CoV-2, has highlighted the importance for robust antiviral strategies beyond vaccines and RNA polymerase or main protease inhibitors, which are susceptible to resistance. One promising therapeutic target is the S-CoV-2 papain-like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 46–62 Read article
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Low Velocity Impact Behaviour of Corrugated Foam Sandwich Panel
Abstract: Composite sandwich structures, renowned for their high flexural stiffness and low weight, are widely used across industries such as aerospace, automotive, and marine. However, their durability can be compromised by impact-related damages, which affect both the core and face sheets. This study explores the performance of corrugated sandwich panels compared to conventional designs under low-velocity impacts. Using a drop weight impact testing machine, panels made from polyurethane foam cores and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 79–99 Read article
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Mid-Year Epidemiological Profile of COVID-19 Posi ve Cases in Rajasthan, India
Abstract: Background: COVID-19, caused by SARS-CoV-2, has posed persistent public health challenges globally since its emergence in late 2019. India, through enhanced surveillance and vaccina on, has seen a progressive decline in case burden. Despite improvements, localized surges and emerging variants necessitate con nuous monitoring. Rajasthan, with its urban-rural health dispari es, experienced a modest resurgence of cases in early 2025, raising concerns about exis ng immunity gaps and health system …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Azepines, Chemistry, Synthesis and Reactions
Abstract: Azepines, which consist of a seven-membered cyclic compound featuring six carbon atoms, an additional nitrogen atom, and no double bonds between carbons, form a diverse group within organic chemistry. The fully hydrated form of this compound is called azepam (C6H13N). Compounds and their variants play crucial roles in pharmaceutical research due to their biologic attributes like cancer-fighting, bacteria-killing, fungus-busting, virus-suppressing, and inflammation-reducing capabilities. Various organic molecules found within nature draw …
Published in International Journal of Minerals · Vol. 2, Issue 2, 2025 · pp. 35–45 Read article
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A Decade of Viral Evolution (2015–2025): Emergence, Mutations, and Implications for Global Health
Abstract: Over the past decade (2015-2025), viral evolution has profoundly reshaped the global health landscape, challenging healthcare systems, diagnostic tools, therapeutic strategies, and vaccine efficacy. This review comprehensively analyzes the evolutionary trajectories of major human and zoonotic viruses, with a focus on pandemic-prone, drug-resistant, and emerging pathogens. Viral evolution is driven by diverse molecular mechanisms including high mutation rates, recombination, reassortment, host immune pressure, and antiviral interventions, leading to genetic diversification, …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 31–40 Read article