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277 articles for “disease mechanism”
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Advancements in Plant Molecular Biology and Genetics: Insights into Genetic Engineering, Genomics, and Crop Improvement
Abstract: This comprehensive review explores the rapidly advancing fields of plant molecular biology and genetics, offering a thorough examination of contemporary research and innovative methodologies that contribute to a deeper understanding of plant development, improved crop productivity, and the mitigation of environmental challenges. Recent breakthroughs in genetic engineering, genomics, and transcriptomics are thoroughly analyzed to provide valuable insights into their practical applications for sustainable agriculture. The integration of cutting-edge tools and …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 1, 2025 · pp. 25–27 Read article
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 15–26 Read article
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Emerging Trends in Photobiology: Exploring the Photophysics and Photobiology of the Eye
Abstract: The eye consists of three main segments: the cornea, lens, and retina. The primary function of the anterior ocular tissue, the cornea and lens, is to transmit and focus light onto the retina without distortion. They also filter UV light (under 400 nm), preventing it from reaching the retina. While light reaching the retina is mostly used for vision, it can also have various effects on the eye's constituents, both …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 1, 2025 · pp. 31–37 Read article
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A Note on Vaccine Design Using Bioinformatics Methods and Applications
Abstract: Vaccines prevent infectious diseases caused by viruses and bacteria saving millions of lives.It consists of certain agents that resemble disease causative agentsand stimulates our immune system to recognize and fight foreign antigens. Immune function or an immune response is the fundamental basis of the vaccine's mechanism. Vaccines are pharmaceutical derivatives that provide an affordable way to prevent diseases.Various bioinformatics approaches can be incorporated into vaccine design studies and development. Reverse …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
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Screening of Mustard Varieties and Lines against Clubroot and Alternaria Leaf Spot Diseases
Abstract: The experiment was conducted to find out the resistant varieties/lines against clubroot and Alternaria leaf spot diseases of mustard at the Plant Pathology Division, RARS Jamalpur, Bangladesh during the Rabi season of 2024-2025 with sixty-two (62) varieties and lines of Mustard collected from Oilseed Research Centre (ORC) and Plant Genetic Resources Centre (PGRC), Joydebpur, Gazipur-1701, Bangladesh. To screen for clubroot and Alternaria leaf spot diseases and to evaluate yield and …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 97–106 Read article
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Millet Bran: Unveiling Its Potential Health Benefits
Abstract: Millet bran, derived from various millet grains, has emerged as a potent nutritional source, rich in fiber, vitamins, minerals, antioxidants, and omega-3 and omega-6 fatty acids. Its rising popularity is driven by its gluten-free nature, nutrient density, and sustainability. This review aims to explore the potential health benefits of millet bran, focusing on its digestive health, blood sugar control, heart health, antioxidant properties, and fatty acid composition. The Millet brand …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 11–19 Read article
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Recent Advances in Smart Polymer Composites for Plant Health Monitoring: A Strategic Integration of Sensing Mechanisms and Computational Intelligence
Abstract: Plant health assessment is crucial for agricultural production and food security, as plant diseases significantly affect crop yields and quality. This paper reviews the applications of polymers and composite materials in the evaluation of plant health, focusing on both natural and artificial polymers, carbon materials, and polymeric–nanoparticle composite materials. Various types of sensing principles, such as colorimetry, fluorimetry, surface plasmon resonance (SPR), surface enhanced Raman scattering (SERS), and interferometry, are …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1135–1144 Read article
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Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
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Bacilli: The Keystone Biocontrol Agents Eradicating Phytopathogens
Abstract: As a result of the niches provided by plants to microbes, multitude of interactions occurred some of which are detrimental to the plants, including pathogenicity which results in diseased plants caused by harmful microbial community inhabiting a plant. Studies have shown that pesticides are applied to control the disease-causing microbes, but the adverse effects of the pesticides have necessitated the need for biocontrol agents that are eco-friendly. In this article, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 1, 2023 · pp. 22–32 Read article
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Cancer Treatment by Radionuclide Therapy
Abstract: Recently, pretargeted nuclear imaging and radiotherapy have gained tremendous attention for diagnosis and treatment of cancer with nanomedicines. Radionuclide therapy (RNT) is one of the rapidly growing fields of nuclear medicine which works on the mechanism of delivery of cytotoxic levels of radiation to the disease sites, sparing the normal cells. RNT targets diseases at the cellular level rather than on a topographic anatomical level when compared to conventional external …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 2, 2018 · pp. 4–7 Read article
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Thymoquinone Induces Epigenetic Modulation in ROS Dependent Manner
Abstract: Traditional drugs have the ability to treat broad range of diseases by modulating the signaling pathwaysof inflammatory diseases and cancer. Epigenetic modulation is also one of the mechanisms already established as a process of action. Histone deacetylase (HDAC) inhibition leads to changes in gene expression promoting cell death. Thymoquinone (TQ), a bioactive compound from Nigella sativa seeds has shown to have an antineoplastic effect in many cancers. Here we have …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 32–39 Read article
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A Perspective Review on Role of Environmental Pollutants in Developing Neurodegenerative Diseases
Abstract: As human society progresses towards industrialization, an excess number of environmental pollutants are released to our ecosystem, which significantly contribute in causing various health issues primarily associated with neurodegenerative diseases such as cognitive disorder, dementia, anxiety, Alzheimer, Parkinson etc. Because of their high global occurrence, these diseases have attracted attention in recent decades, however, the etiology of these diseases remains unclear. Pollutants are discharged into the environment by natural events …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 1–18 Read article
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Exploring the Therapeutic Potential of Phytohormones: Bridging Plant Immunity and Human Health
Abstract: This review highlights the multifaceted roles of phytohormones, including salicylic acid, abscisic acid, cytokinins, and brassinosteroids, emphasizing their contributions to plant immunity and potential therapeutic applications in human health. Phytohormones are critical regulators of plant growth, development, and defense, functioning as signaling molecules that activate and coordinate plant responses to biotic and abiotic stresses. Salicylic acid, in particular, is instrumental in systemic acquired resistance (SAR), a defense mechanism that strengthens …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 20–23 Read article
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Epidemiology and transmission of infectious diseases study using Machine learning
Abstract: Infectious diseases remain a formidable global health challenge, characterized by rapid evolution and complex transmission dynamics that often outpace traditional epidemiological surveillance and response mechanisms. This study investigates the transformative potential of machine learning (ML) methodologies to enhance our understanding and prediction of infectious disease epidemiology and transmission. Leveraging diverse datasets—including clinical records, genomic sequences, environmental factors, social mobility data, and real-time digital footprints—we studies and presented various ML models …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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An Essay Discussing Budd-Chiari Syndrome
Abstract: Budd-Chiari syndrome (BCS) is defined as hepatic venous outflow tract obstruction, independent of the level or mechanism of obstruction, provided the obstruction is not due to cardiac disease, pericardial disease, or sinusoidal obstruction syndrome (veno-occlusive disease). Primary Budd-Chiari syndrome is present when there is obstruction due to a predominantly venous process (thrombosis or phlebitis), whereas secondary Budd-Chiari is present when there is compression or invasion of the hepatic veins and/or …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 2, 2023 · pp. 7–14 Read article
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Cadmium and Apoptosis: A Molecular Approach
Abstract: Apoptosis, also known as programmed cell death is a highly regulated and fundamental process found in all multicellular organisms. It is not only implicated in regulatory mechanisms of cells, but has been attributed to a number of diseases, like inflammation, malignancy, autoimmunity and neuro-degeneration. A variability of pollutants can persuade apoptosis. Oncogenic transition metals like cadmium, promote apoptosis alongside DNA base modifications, strand breaks and rearrangements. Generation of reactive oxygen …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 1, 2016 · pp. 8–17 Read article
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Climate Change and the Spread of Pathogens: Implications for Public Health
Abstract: Climate change plays a significant role in the spread of infectious diseases by shifting how pathogens behave, affecting how vulnerable hosts are, and changing the way diseases are transmitted.Rising global temperatures, changing precipitation levels, and extreme weather events are accelerating the spread of bacteria, viruses, fungi, and parasites, increasing the risk of outbreaks worldwide. Warmer conditions favor the survival and expansion of vector-borne diseases such as malaria, dengue, and Zika …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 1–5 Read article
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Dengue in India : Insights in the Indian Context
Abstract: The mitigation of infectious diseases in India, notably Dengue, assumes pivotal importance due to their significant repercussions on human and animal health, thereby imposing a considerable burden on the healthcare infrastructure. This review underscores the ongoing initiatives in infectious disease management, endorsing the implementation of a comprehensive healthcare strategy. Emphasis is placed on the augmentation of reporting mechanisms through the integration of IgM detection kits, advocating for heightened investments in …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 10–13 Read article