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103 articles for “Mechanisation”
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Early Life Nutrition as a Determinant of Long-Term Vaccine Immunogenicity in Livestock: Mechanisms, Practical Strategies, and Species-Specific Considerations
Abstract: Early life represents a critical period for immune system development in livestock, during which nutritional exposures can exert long lasting effects on vaccine immunogenicity. Although vaccination is a cornerstone of infectious disease control in food producing animals, marked variability in vaccine induced immune responses is frequently observed under commercial conditions. Growing evidence suggests that this variability is partly driven by differences in early nutritional status, which can influence immune maturation, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 34–46 Read article
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 15–26 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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Functional Biomolecules in Animal Nutrition: Biochemical Mechanisms and Their Impacts on Growth Performance and Health Outcomes
Abstract: Functional biomolecules have emerged as critical modulators of animal nutrition, extending beyond conventional nutrient supply to regulate biochemical and physiological processes that determine growth performance and health outcomes. This review synthesizes current knowledge on diverse classes of bioactive compounds, including amino acids, peptides, fatty acids, vitamins, minerals, phytochemicals, and microbial-derived metabolites, and their roles in livestock systems. Emphasis is placed on underlying biochemical mechanisms such as enzyme activation, nutrient signaling …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article
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Solid Acid Catalysts for the Selective Conversion of Biomass to Levulinic Acid
Abstract: Levulinic acid (LA) has emerged as a versatile platform chemical with significant potential for producing renewable fuels like gamma-valerolactone (GVL), biodegradable polymers, and fine chemicals from biomass (both terrestrial and marine which ae rich in carbohydrate). The selective conversion of biomass-derived carbohydrates to LA requires efficient catalytic systems that can overcome the recalcitrance of the biomass, namely the stiff-necked structural integrity of cellulose and the kind of strong interactions between …
Published in Journal of Catalyst & Catalysis · Vol. 13, Issue 1, 2026 · pp. 23–35 Read article
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Phosphorescence of Carbon Nanodots – The Phenomena and the Applications
Abstract: Photoluminescence has emerged as a fundamental phenomenon in modern biomedical science, enabling advanced diagnostic, therapeutic, and theranostic applications through light–matter interactions at the nanoscale. The ability of photoluminescent materials to absorb electromagnetic radiation and emit light at distinct wavelengths has been widely exploited in bioimaging, biosensing, drug delivery tracking, and photodynamic therapy. Among various photoluminescent nanomaterials, carbon nanodots have attracted significant attention due to their strong emission intensity, tunable fluorescence, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 01–05 Read article
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Muscle vs. Heart: A Comprehensive Review of Anabolic Steroid-Induced Cardiovascular Risks
Abstract: Anabolic-androgenic steroids (AAS) are widely used by athletes and bodybuilders to enhance muscle mass and performance. However, their misuse is associated with serious and often underrecognized cardiovascular risks. Despite their popularity, particularly among young adults, the long-term consequences of AAS abuse on cardiovascular health remain insufficiently explored in the literature. This review aims to: 1. Analyze the cardiovascular implications of AAS use. 2. Elucidate the molecular and physiological mechanisms contributing …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 Read article
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Comparative Analysis of Polymer-Enhanced and Conventional Magnetorheological Fluids in E-Bicycle Semi-Active Suspension
Abstract: In light of the increased use of electric bicycles as a sustainable transport means, various mechanical challenges emerge which were absent in traditional bicycles, primarily concerning vibration isolation and riding comfort. Indeed, hub motors, batteries and the entire drivetrain system produce dynamic excitations which passive suspension cannot handle effectively. This paper presents a comparison of conventional magnetorheological (MR) fluid and the polymer-based MR nanocomposite fluid within the context of semi-active …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1174–1185 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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Framework-Based Optimization of Catalysis Efficiency through Reaction Pathway Engineering
Abstract: The rational design of heterogeneous catalysts through framework-based approaches has emerged as a transformative strategy for controlling reaction pathways and enhancing catalytic efficiency. This paper examines recent advances in the optimization of catalytic performance through engineered frameworks, including metal-organic frameworks (MOFs), zeolites, and related porous materials. By integrating computational methods with experimental validation, researchers have achieved unprecedented control overactive site architecture, reactant confinement, and elementary reaction steps. This work reviews …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 2, 2026 · pp. 88–99 Read article
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Copper Sulfide Semiconducting Nanoparticles for Antibacterial Applications: Synthesis Strategies, Mechanisms and Performance – A Review
Abstract: Copper sulfide nanoparticles (CuS NPs) have drawn growing attention as a next-generation antibacterial platform, owing to their tunable structural, optical, and catalytic properties. This review consolidates current evidence on CuS NP synthesis, mechanisms, and antibacterial performance, comparing chemical and green synthesis routes alongside the effects of morphology, doping, and surface modification. Mechanistically, CuS NPs act through several overlapping pathways, including reactive oxygen species generation, bacterial membrane disruption, ion release, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 236–253 Read article
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Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways
Abstract: Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 25–30 Read article
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A Threshold-Weighted Mathematical Fusion Model for Epidemic Outbreak Prediction Using SEIR Residual Dynamics and Cloud-Based Machine Learning
Abstract: Accurate prediction of epidemic outbreaks is critical for effective public health management, resource planning, early warning generation, and timely intervention by municipal authorities. Traditional compartmental models such as Susceptible–Exposed–Infectious–Recovered (SEIR) offer valuable epidemiological insights and mathematical interpretability; however, they may not adequately capture the complex nonlinear relationships present in real-world urban health systems. Conversely, data-driven machine learning techniques can identify hidden patterns in large datasets but often lack epidemiological structure …
Published in Research & Reviews : Journal of Statistics · Vol. 15, Issue 2, 2026 · pp. 12–19 Read article
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Cost Effective Automatic Garage Door Mechanism With Variable Speed
Abstract: The aim of our project is to provide safety as well as security to people from the largest electromechanical objects which are available at home. An automatic garage door mechanism was selected as a subject of our research as it is the complex electro-chemical object at home. As technology increases day by day every households installs this automatic garage door mechanism. The major problem with the conventional garage door system …
Published in Journal of Automobile Engineering and Applications · Vol. 8, Issue 1, 2021 · pp. 1–5 Read article
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Catalytic Applications of Copper Species in Organic Transformations: A Review
Abstract: Copper a naturally occurring element is present in the earth's crust, in oceans, lakes, and rivers, from minute trace element levels through to rich mine deposits. It is essential to life – plants, fish, animals and humans all need copper to function properly. Homogeneous copper catalyzed reactions are widely used for the construction of important organic molecules, including pharmaceuticals, commodity chemicals, and polymers. The development of copper catalysis has been …
Published in Journal of Catalyst & Catalysis · Vol. 1, Issue 2, 2014 · pp. 21–34 Read article
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Design and Fabrication of Footstep Power Generator
Abstract: AbstractOne of the major problems faced in today’s world is energy crisis. This paper puts forth the discussion about the design and fabrication of foot step power generator. The project shows possibility of generating power when people walk on the floor. It utilizes energy exerted in the form of pressure on to the floor to produce electricity. The idea deals with converting the self weight of a person to electrical …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 8, Issue 1, 2018 · pp. 17–20 Read article
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An Overview of Heavy-ion Collisions
Abstract: AbstractA large number of experiments have been performed to explore the heavy-ion collisions dynamics using accelerator facilities available in India. The experimental results have revealed that in reactions induced by nucleons or light particles at energies of the order of a few tens MeV, the great majority of the processes one observes are of statistical nature though they cannot be interpreted as a consequence of the decay of a fully …
Published in Journal of Nuclear Engineering & Technology · Vol. 9, Issue 2, 2019 · pp. 8–23 Read article