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118 articles for “Genetic”
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
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Managing Carpal Tunnel Syndrome: Insights into Symptoms and Relief
Abstract: Carpal tunnel syndrome (CTS) is a prevalent and concerning issue affecting the wrist and hand, arising from the compression of the median nerve within the carpal tunnel. This compression results in a spectrum of distressing symptoms, including numbness, tingling, weakness, and discomfort, particularly in the thumb, index, and middle fingers. Despite its frequent association with repetitive hand movements and prolonged use of computers or handheld devices, CTS can stem from …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 6–12 Read article
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Intervertebral Disc Bulge in Young Individuals: Causes, Symptoms, and Remedies
Abstract: The prevalence of intervertebral disc bulge among younger individuals has raised concerns regarding its causes, symptoms, and potential remedies. This condition, typically associated with older age, has increasingly affected younger demographics. Understanding the causes behind this phenomenon is critical in addressing its impact on the younger population. The study delves into the key aspects related to intervertebral disc bulge among young individuals. The causes of intervertebral disc bulge in young …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 13–18 Read article
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Unraveling Metagenomics: A Comprehensive Diagnostic Approach for COVID-19
Abstract: The COVID-19 pandemic has brought attention to the need for rapid, accurate, and scalable diagnostic techniques. Metagenomics, a powerful technique that enables the comprehensive analysis of genetic material from complex microbial communities, has emerged as a promising diagnostic approach for COVID-19. This article elucidates the principles of metagenomic sequencing, highlighting its ability to detect viral RNA directly from clinical samples without prior knowledge of the pathogen. Furthermore, we discuss the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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A Study to Assess the Stress and Anger Management by Deep Breathing Exercise and Meditation Among Adolescent Nursing Students at a Selected Nursing School in Delhi
Abstract: Introduction: Stress is a response that can lead to physical, emotional, or psychological strain. It is a frequent occurrence in daily life. Stress acts as the body's natural mechanism for defense against potential threats and dangers. It initiates a release of hormones that ready the body's functions to either confront danger head-on or retreat, commonly known as the fight-or-flight reaction. Anger can be caused by both external and internal events …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 15–19 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Disease: A Major Stumbling Block in the Growth of Aquaculture
Abstract: Aquaculture plays a crucial role in ensuring food security, fostering economic development, and providing recreational opportunities worldwide. However, the intensification of aquaculture practices has led to a surge in environmental challenges, including water pollution, soil acidification, eutrophication, chemical contamination, and the spread of diseases. Among these, diseases caused by bacteria, viruses, fungi, and parasites pose significant threats to the sustainability of global aquaculture. Despite the implementation of various diagnostic methods …
Published in International Journal of Marine Life · Vol. 1, Issue 1, 2024 · pp. 25–28 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Studies On The Length-Weight Relationship And Morphometric Characteristics of Rohu, Labeo Rohita (Hamilton) From Pond In Radhamohanpur, Jirania, Tripura, India
Abstract: The present study describes the length–weight (LWR) relationship and morphometric characters of 30 specimens of the rohu, Labeo rohita (Hamilton) collected from the pond situated in Radhamohanpur, Jirania, Tripura, India over a period of six months extending from (January 2020-June 2020). The fish were caught by traditional fishing gear. Total length (TL) reading has been taken from Vernier Calliper and Body weight (BW) measured with digital balance. The readings of …
Published in International Journal of Marine Life · Vol. 1, Issue 2, 2024 · pp. 27–34 Read article
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Trauma- Its Transgenerational Inheritance and Associated Nuances in Perinatal Care: A Systematic Review
Abstract: The research is a systematic review of the existing clinical and animal studies pertaining to effects of trauma on immediate offsprings and its transgenerational inheritance. The research also summarises the current statistical data on perinatal care globally with special emphasis on India as a developing nation and the current strategies, government policies and international recommendations on maternal and child health as put forward in the Sustainable development goal 2030 by …
Published in International Journal of Children · Vol. 1, Issue 1, 2024 · pp. 37–45 Read article
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A Comprehensive Review on Long-term Care Policies for Intellectual and Developmental Disabilities
Abstract: Intellectual disability (ID) is a neurodevelopmental difficulty that affects both intellectual functioning and adaptive behaviour. The term IDD describes a broad range of long-term disorders that are caused by either physical or mental deficits. These disorders can influence numerous facets of life, such as self-care, social skills, communication, and education. This condition affects social and practical abilities daily. Conditions like cerebral palsy, Down syndrome, and autism spectrum disorder, Genetic predispositions, …
Published in International Journal of Trends in Humanities · Vol. 1, Issue 2, 2024 · pp. 36–42 Read article
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Bacteriophages- A New Frontier in Medicine
Abstract: Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering an innovative alternative to traditional antibiotic treatments, especially in the face of rising antibiotic resistance. The resurgence of phage therapy has been driven by the increasing prevalence of multidrug-resistant bacterial strains and the slowdown in the development of new antibiotics. Phages, unlike antibiotics, target specific bacterial strains, reducing the impact on the natural microbiota and potentially offering a …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 31–35 Read article
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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Exhaustive Search Meets DNA Sequencing: A Comprehensive Review of TSP-Based Approaches
Abstract: Exhaustive search is a highly computational complex algorithm that checks every possibility to obtain the best solution. We illustrate an exhaustive search by applying it to three important problems: the traveling salesman problem, the knapsack problem, and the assignment problem. In this paper, we took a traveling salesman problem to explain DNA Sequencing. Since traveling salesman problem is an algorithmic problem that finds the shortest route between a set of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 11–21 Read article
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Malaria Diagnosis through Conventional Methods: A Comprehensive Review
Abstract: The incidence of drug-resistant parasite strains is rising, there is an apparent increase in the number of cases of malaria worldwide, and in a small number of cases and there has been a dramatic rise in international migration and travel. Over 1 million people die from malaria every year; 90% of these deaths are in African children, who live in tropical and subtropical regions. Although there are now efficient techniques …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 8–14 Read article
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Microbial Symphony: Understanding Biochemical Pathways for Precision Medicine and Beyond
Abstract: The human microbiome, an intricate ecosystem of microorganisms inhabiting the body, is a key regulator of host biochemistry and physiology. This review delves into the complex biochemical pathways influenced by the microbiome, spotlighting critical metabolites like short-chain fatty acids, bile acids, and tryptophan derivatives, which impact immune regulation, energy metabolism, and neurobehavioral functions. By examining interactions between the microbiome and the host, including the influence of genetic factors and metabolite-driven …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 28–43 Read article
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Path and Trajectory Planning of Unmanned Ground Vehicles with Vehicle Dynamic Characters
Abstract: Given partial knowledge about its environment (obstacle, road…) and goal position, optimal path and trajectory planning is a key problem for the control of unmanned vehicles. In path planning problem, it is very important to consider the dynamic limits of the vehicle with optimization function. The path planning was implemented by applying optimization methods based on the given obstacle information(virtual or measured by sensor system) and numerical map without considering …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 2, Issue 2, 2024 · pp. 7–14 Read article
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Examining the Role of Synthetic Biology in Cellular Restoration Mechanisms
Abstract: Synthetic biology has emerged as a transformative field with the potential to revolutionize cellular repair mechanisms, offering innovative solutions to repair damaged DNA, stabilize proteins, regenerate tissues, and treat a wide range of diseases. By combining principles from genetic engineering, biotechnology, and computational biology, synthetic biology enables the design of cellular systems capable of performing functions that repair cellular damage and restore normal cellular processes. This article explores the application …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 19–29 Read article
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Molecular Docking of Arjuna Tree Phytocompounds for Ischemic Heart Disease
Abstract: Heart disease is a serious condition that can be caused by several lifestyle changes and sometimes genetic problems. The primary protein component of apolipoprotein is the LDL receptor, which indicates that a reduction in LDL levels can reduce the risk of ischemic heart disease. Apolipoprotein levels are associated with increased levels of ischemic heart disease. Using ADMET analysis, drug likelihood prediction, and molecular docking, this work attempted to find natural …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 42–52 Read article