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1919 articles for “Expression/regulation/sox operon/sulfur-chemolithotrophy” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Drug Product Registration and Regulatory Requirements in Australia (TGA)
Abstract: The present study aims to understand the drug product regulatory requirements and drug product registration process in Australia. Therapeutic Goods Administration (TGA) is the regulatory authority for Australia and is responsible for regulating medicines and medical devices. However, as known, each country has its own regulatory agency to enforce the rules and regulate the guidelines to market a drug substance and drug product. To get authorization of marketing of drug …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 7–15 Read article
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Regulatory Requirements for Pharmaceutical Product Registration in UAE
Abstract: Over the past decade, the healthcare industry in the United Arab Emirates (UAE) has experienced remarkable growth, positioning itself as the second-largest healthcare industry in the Middle East, trailing only Saudi Arabia. Recognizing the significance of healthcare, the UAE government has prioritized its development and actively promoted it as part of the national development plan. The Ministry of Health (MOH) has played a crucial role in this endeavor by allocating …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 1–7 Read article
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Regulatory Requirements for Pharmaceutical Product Registration in Zambia
Abstract: There is a significant burden of diseases in Zambia and its neighboring countries, such as malaria, HIV/AIDS, and other ailments. These health challenges necessitate a high consumption of pharmaceutical products. Currently, the majority of essential health drugs in Zambia are imported from outside of Africa. This reliance on external sources presents an opportunity for new investments in the local manufacturing of pharmaceutical products. Although Zambia may not be the largest …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 33–41 Read article
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A Systematic Review on Leukemia Detection and Classification Techniques Using Gene Expression
Abstract: Early diagnosis of genetic diseases is crucial for effective treatment, especially in the case of Leukemia, a type of blood cancer characterized by abnormal proliferation of white blood cells. This paper presents a systematic review of recent computational techniques for the detection and classification of Leukemia using gene expression data obtained from DNA microarray analysis. The study explores diverse methodologies including machine learning (ML), deep learning (DL), and bio-inspired algorithms …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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India’s Traditional Medicine Trade (2015–2024): Trends, Regulatory Landscape, and Policy Directions for Sustainable Growth
Abstract: India is a major global supplier of traditional medicine products – including Ayurvedic, Unani, Siddha, homeopathic, and other herbal and plant-based formulations – yet exports continue to face challenges arising from regulatory divergence, heterogeneous quality-control requirements across markets, and raw-material supply constraints linked to biodiversity pressure and fragmented value chains. This paper systematically analyzes India’s import-export patterns for traditional medicine between 2015 and 2024, maps the regulatory landscape (DGFT, Drugs, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 13–18 Read article
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Proposed Modified PID Load Frequency Controller for Two Area Interconnected System Employing Frequency Regulation Techniques of Wind Power Plant
Abstract: AbstractFrequent switching of load introduces noisy ambiances and makes the implementation of conventional PID controller challenging, as differential part of controller is noise sensitive. Thus, this paper proposes a modified PID load frequency controller for two area interconnected system, employing frequency regulation techniques of wind power plant, and compares the performance of modified PID load frequency controller with the conventional PID controller. Wind power plant with inertial control has been …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 8, Issue 2, 2017 · pp. 1–10 Read article
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Analysis of Regular And Irregular High Rise (G+30) Building For Seismic Zone V.
Abstract: Earthquake is a vital parameter to be considered while designing structures. Lots of work has beendone by researchers who worked to study the effect of regular, irregular and its shape of thestructure. The main aim of the project is, comparative study of regular and vertically irregular(G+30) building in seismic zone V for different soil condition is done. The results are tabulated andgraphs are plotted for displacement, drift, base shear, and …
Published in Journal of Construction Engineering, Technology & Management · Vol. 11, Issue 1, 2021 · pp. 22–34 Read article
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Nuclear Safety and Regulation: A Review
Abstract: AbstractNuclear safety is defined by the International Atomic Energy Agency as “The achievement of proper operating conditions, resulting in protection of workers and environment from hazardous radiations”. The nuclear industry has continuously improved its safety standards and several regulatory boards monitor the nuclear setups to maintain the safety. However, many instances the safety lapse has resulted in disasters. The IAEA works in conjunction with member states and partners worldwide to …
Published in Journal of Nuclear Engineering & Technology · Vol. 7, Issue 2, 2017 · pp. 29–31 Read article
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Detection of Cervical Cancer Using lncRNA Expression Data and Detection of Possible Biomarkers with Bagged CART Machine Learning Method
Abstract: Aim: Cervical cancer (CC), one of the most common gynecological cancers, occurs when the cell layer that forms the surface of the cervix turns into abnormal cells. This type of cancer ranks fourth in cancer-related female deaths, and 3.6% of women living in developed countries suffer from this disease, while approximately 15% of women living in underdeveloped countries are exposed to this cancer. The primary means of reducing the high …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 12–20 Read article
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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RCT to Assess the Effectiveness of 24% Oral Sucrose Solution (OSS) versus Expressed Breast Milk (EBM) in the Management of Neonatal Pain
Abstract: Despite, a growing body of knowledge about the physiology of neonatal pain, the evolution of neonatal pain assessment tools, and pain management guidelines, there persist a wide variety of opinions among health care providers about how to treat pain in the neonates. Newborns feel pain and require the same level of pain assessment and management as adults. Scientific research in recent years has continued to confirm that neonates, especially when …
Published in Research and Reviews: A Journal of Health Professions · Vol. 3, Issue 1, 2013 · pp. 9–14 Read article
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Switch Movement: Overview of Various Key Attributes on Regulatory Scenario of OTC Legislations in U.S.
Abstract: The Rx-to-OTC switch was a phenomenal success in USA, which was based on risk/benefit ratio of all scientific evidences in collaboration with FDA, manufacturer and consumers. Different surveys speak about the success stories of Rx-to-OTC movement as consumers experience the benefit from self-care in terms of empowerment, convenience, savings of money and time, etc. OTC perspective of scientific and regulatory bodies is based upon a valid procedure and just not …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 24–31 Read article
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Regulatory Concerns in Imports, Exports and Registration of Drugs and Dietary Supplements
Abstract: The main aim of this article was to study the various pharmaceutical products registration processes, regulations and requirements by the Indian Regulatory Authorities. The study emphasizes on the challenges faced by stakeholders entering into the Indian market without difficulty by demonstration of strategy arrived from the established guidelines, regulations and expert opinion. The study was undertaken to identify the challenges in biosimilar developments and dietary supplements and to evaluate the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 13–22 Read article
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Application of pET28a Vector for the Over Expression of Recombinant Human Tim23 Protein in E. coli and its Validation by Immunoblotting
Abstract: This study aimed to produce recombinant human Tim23 protein by molecular cloning, expression, and purification. Amplification of human TIM23 was carried out by polymerase chain reaction (PCR) and cloned into DH5α cells. The pET28a-human TIM23 was transformed into BL21DE3 and expressed the gene by IPTG induction. Recombinant pure human Tim23 antigen was prepared, and injected into rabbits and polyclonal antibodies were raised, which was confirmed by western blotting. The transformed …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 32–44 Read article
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Research on Synchronous Generators AC Excitation Regulation Control System
Abstract: Based on various methods to supply excitation power to the synchronous generator it is categorized in three different types of excitation systems for synchronous motor. The first one is DC excitation system, second is AC excitation system and third one is static excitation system. The increasing size of contemporary power systems ensures system dependability and stability. A better supply of power is vital and has a big influence on improving …
Published in International Journal of Electrical Power and Machine Systems · Vol. 2, Issue 2, 2024 · pp. 10–16 Read article
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A New Analytical Expression of Channel Capacity with MRC Diversity Over Composite Model of α-μ/Inverse Gaussian Fading Distribution
Abstract: Abstract: Fading in a wireless communication system occurs basically due to two phenomena, multipath fading, and shadowing. A realistic scenario would comprise of both the phenomenon occurring simultaneously. Such a scenario is frequently characterized by a composite model of multipath/shadowing fading. In this work, a novel expression for the composite model of αμ/Inverse-Gaussian (IG) distribution with MRC diversity is obtained using the GaussLaguerre integration technique. Further utilizing the obtained expression …
Published in Journal of Microelectronics and Solid State Devices · Vol. 6, Issue 1, 2019 · pp. 22–29 Read article
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A Study to Assess the Effect of Audio Drama on Menstrual Hygiene and Reproductive Health in Terms of Knowledge and Expressed Practices among Visually Challenged Adolescent girls at Selected Blind Schools, Haryana
Abstract: Health is an essential factor for a happy contended life. Change makes life more beautiful and worth living if one knows how to adopt oneself and adjust to the challenges presented by the situation, she can face any challenge in life. The changes are more frequent in girls than boys, girl’s mature earlier reach the period of rapid growth earlier than boys. The rapid growth and change in the physical …
Published in Journal of Nursing Science & Practice · Vol. 11, Issue 3, 2021 · pp. 7–14 Read article
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Cloning and Expression of LPS-Binding Single Domain Antibody Clones Selected from Phage Display Library of Indian Desert Camel
Abstract: Despite the absence of light chains in their structure, camelid and shark “heavy chain antibodies” (HCAbs) variable domains (designated as VHH) are able to make functional paratopes. The authors have selected lipopolysaccharide (LPS)-binder “single-domain antibodies” (dAb) clones from the previously constructed phage display library of (LPS)-immunized Indian desert camel. This study was undertaken to make available large amounts of some LPS-binder dAb clones by using a suitable expression vector-host system …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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Diverse microRNAs Expressed in Five Prominent Cancers Worldwide
Abstract: MicroRNA being a small RNA molecule plays an important role in the process of transcription of gene to mRNA. The importance of several numbers of microRNAs has been studied till date. They are capable of aiding in normal functioning of an organism. At the same time, their expression can have serious effects in different diseases. Many numbers of miRNAs has been reported to play vital roles in progression as well …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 1, 2018 · pp. 1–9 Read article