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1653 articles for “rats”
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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Exploring the Thyroid Gland Physiology in Relation to Thyroid Hormones: An Overview through the Lens of 3D Computational Biology
Abstract: The endocrine system plays a pivotal role in orchestrating and sustaining diverse physiological functions by manufacturing and releasing hormones, which function as vital chemical messengers within the body. Among the prominent endocrine glands, the thyroid gland holds a central position. Situated in the lower part of the neck, this gland adopts a butterfly-shaped structure. Its significance lies in the synthesis of three key hormones: thyroxine (T4), tri-iodothyronine (T3), and calcitonin.The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 46–54 Read article
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Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
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REPEATED MOPs VS DUAL APPROACH IN ACCELERATED ORTHODONTICS
Abstract: In contemporary orthodontics, there is a pressing need to minimize treatment duration, which is often a concern for both orthodontic specialists and patients. Prolonged treatment periods not only pose logistical challenges but also increase the risks of various dental issues such as cavities, periodontal problems, chronic discomfort, and root resorption. Accelerated orthodontics has emerged as a promising solution to address these challenges. Numerous efforts have been undertaken to expedite orthodontic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 16–21 Read article
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Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
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A Conceptual Exploration of Carbohydrate, Protein, and Fat Metabolism within the Realm of 3D Computational Biology
Abstract: Maintaining energy balance within the body is just as crucial as other vital physiological processes. Energy is generated through a myriad of chemical reactions occurring within the cells of all living organisms. This unique characteristic enables living organisms to extract energy from their surroundings and utilize it for essential activities such as growth, development, and reproduction. While it is commonly assumed that individuals with lower body weight have higher metabolic …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 55–62 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Forms
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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A study conducted among young women living in specific locations of Honavar, Uttara Kannada, to evaluate their attitudes and knowledge about women abuse. With a view to organize a Mass Health Education Programme
Abstract: Worldwide and regional projections of violence against women indicate More than 25% of women in relationships between the ages of 15 and 49 report having experienced physical or sexual abuse at least once in their lifetime (since they were 15). Up to 38% of all female killings globally are the result of intimate relationship violence. Apart from domestic violence, 6% of women worldwide report experiencing sexual assault at the hands …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 5–12 Read article
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Biomaterials and its Role in Dentistry–A Review
Abstract: Increasing success through modern techniques in implantology brought a new transformation in dentistry field to successfully replace missing teeth. To inflate the success rate, regular and continuous attempts are done to improve the materials, techniques for comprehensive understanding of implant behavior to the biological system. Biomaterials used for implants and brought in contact with the biological environment play the most symbolic role in the success of treatment modality. This has …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 339–352 Read article
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Identification and Categorization of Brain Tumors
Abstract: Brain tumors are a serious and aggressive disease that can lead to a reduced life expectancy. Strategic and well-thought-out treatment planning significantly contributes to improving a patient's overall quality of life. Many different imaging techniques, such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and also ultrasound are used to evaluate tumors in different parts of the body, with a focus on using MRI images for brain tumors. It is …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 32–37 Read article
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Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
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Removal of Chloride from Ground Water Using Natural Adsorbent: Water Hyacinth
Abstract: Groundwater contaminants in rural areas often include chlorides and hardness. Nowadays, due to water scarcity, there is a need to utilize groundwater for construction purposes. According to IS 456:2000, the chloride content in water used for mixing and curing concrete must not exceed 2000 mg/l for plain concrete and 500 mg/l for reinforced concrete work. An excess amount of chloride in water causes the deterioration of structures. Concrete durability and …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 1, 2024 · pp. 49–55 Read article
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A study to assess the effect of nutritional supplementation on the hemoglobin level and the associated signs and symptoms of the students identified with anaemia in selected colleges of SNDT Womens’ University Mumbai
Abstract: The purpose of this study was to assess the effects of nutritional supplements on haemoglobin levels and related symptoms among students at SNDT Women's University in Mumbai who had been diagnosed with anaemia in a few particular institutions. Non-occurrence A sample of thirty anaemic students was selected via easy sampling. With a one-group pre-test-post-test methodology, the study used a descriptive evaluative design. Data collecting instruments included measurement devices, opinion questionnaires, …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 16–25 Read article
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The Study On Sphaeranthus Indicus
Abstract: The increasing usage of plant-based medications is mostly due to their lower costs, greater efficacy, and little or nonexistent adverse effects as compared to contemporary medications. To support the claims made about medicinal plants in traditional medicine systems, a great deal of research is being done on them. The Asteraceae family includes the aromatic herb Sphaeranthus indicus. It thrives as a weed in paddy fields and is found throughout India's …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 37–43 Read article
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Benefits of Use of Microalgae in Spacecraft
Abstract: In this time of modern science and technology, we need sustainable development, so that we can meet the demand of future generations as well as the present generation. For this reason, scientists are trying to develop such products which have a considerable remark on every research. Consuming algae as a human food became popular over 70 years after it was discovered in 1942. This concept was first implemented in spacecraft …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 08–12 Read article
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Electrical Discharge Machining for Precision Metal Working Industries
Abstract: EDM is called as Electrical Discharge Machining. Otherwise called as Spark Erosion Machining, Electro-Erosion Machining, Spark Machining, and Electro Discharge Machining. It is an unconventional machining process to machine hard metals and alloys. EDM has been a significant machining technique. The electrode, work piece materials, dielectric, and the range of pulse rate, current, and voltage make up the basic EDM process. The dielectric serves the following purposes: it transports removal …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 1, Issue 2, 2023 · pp. 7–11 Read article
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Effects of Gypsophila on Airway Inflammation in Guinea pig model of ovalbumin‐induced Asthma
Abstract: To look at how Gypsophlia (GSP) affects airway inflammation in a model of ovalbumin-induced asthma in guinea pigs (OVA).Methods: Using a random number table, sixty healthy female guinea pigs were split into six groups, each consisting of ten rats: the normal control, OVA, and GSP (0.45, 0.9, 1.8, and 3.6 g/kg). The ovalbumin and lipopolysaccharide sensitization approach was used to create the OVA guinea pig model. The GSP groups received …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 17–23 Read article
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Stabilization of Heavy Metal Sludge to Pass the TCLP Test Using Cement with a Sinter as a Additive
Abstract: According to the U.S. Stabilisation is the best-proven technology now in use, according to the Environmental Protection Agency's definition in Title 40, Part 268 of the Code of Federal Regulations (40 CFR 268).This method prevents harmful contaminants from leaking into the environment by physically and chemically trapping them all in a matrix. The investigations used 15 different water-mixed combinations of cement, fly ash, sinter, and lime. The study also examined …
Published in Journal of Polymer & Composites · Vol. 11, Issue 10, 2023 · pp. 16–24 Read article