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Research & Reviews: A Journal of Bioinformatics Original Research

Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics

  1. Shija Tabassum
  2. Alladi Saritha

Abstract

The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of the polymer. In case of tablet of T1containing drug & HPMCK15M (quantity in mg). 200: 15: the release profile, was showing the release 102.69%. In case of tablets of T2 containing drug and HPMC K15M & HPMC K4M (in mg). 200:10:20 it was showing 100.25% release in 24 hours. In case of tablets of T3 containing drug polymer’s (HPMCK15M, HPMCK4M in mg) 200: 15: 15: prepare to be seen in the effect of combination of polymers in release of drug but it was showing same release given 100.25% upto 24 hour. In case of tablets T4 containing drug and HPMC K15M & HPMCK 4M (in mg) 200: 10: 10 the release profile was showing drug release more than 100%. In case of tablets of T5 containing drug and HPMC K 4M & HPMC K15M PVP K30 (in mg) 200: 10: 10:10. Prepared the tablets. But it cannot maintain the release with in 100%. In case of tablets of T6 containing drug and HPMC K 15M (in Mg) 200: 5. It was seen the increase in release of drug and shown more than 100% drug release in 24 hour profile. In case of tablets T7, containing drug. HPMCK4M & HPMCK15M (in mg) 200:10:10 the release profile was showing drug release more than 100%. In case of Tablets T8 containing drug. HPMCK15M (in mg) 200 : 23. The release profile was showing drug release with in 24 hours. With very slower release than all formulations containing % drug release 99.56. Results of stability studies of batch T-8 indicates that it was stable at 40°C/75% + 5% relative humidity as there was no significant difference was observed for dissolution and average drug content data after two months.

Keywords

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