Search
469 articles for “derivatives”
-
Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
-
Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
-
Molecular Docking, QSAR Modeling, and ADMET Evaluation of Novel Pyrazolo-Pyrimidine Derivatives as Potential CDK-2 Inhibitors for Cancer Therapy
Abstract: Cyclin-dependent kinase-2 (CDK-2) is an essential regulator in cell cycle progression and is an important therapeutic target in cancer drug development. In the present study, an integrated computational approach involving molecular docking studies, QSAR modeling, ADMET prediction, and artificial intelligence-based analysis was used to identify pyrazolo-pyrimidine derivatives as potential CDK-2 inhibitors. Based on the molecular docking results, it was found that selected compounds exhibited high binding affinity towards the ATP …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
-
Polymeric Emulsion Composite System Enriched with Eggshell-Derived Biominerals for Dermal Delivery
Abstract: This study describes the development and characterization of a sustainable polymeric water-in-oil (W/O) emulsion composite designed for dermal delivery and skin repair applications. The formulation was prepared using a lipid-rich biopolymeric matrix containing glyceryl stearate, beeswax, and plant-derived ingredients, which acted as the continuous phase for stabilizing and dispersing inorganic mineral fillers. Eggshell waste was utilized as a natural calcium source and combined with magnesium and zinc oxide to create …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
-
Development of an Environmentally Friendly Bioplastic Film Derived from Water Hyacinth
Abstract: The water hyacinth, an invasive aquatic plant negatively impacting ecosystems, serves as a promising source for raw materials in the production of carboxymethylcellulose (CMC)-based bioplastics due to its high cellulose concentration. This initiative not only mitigates water hyacinth pollution in natural water resources but also contributes to the reduction of plastic waste through the creation of biodegradable CMC bioplastic films. The cellulose extraction from water hyacinth precedes the synthesis of …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 18–24 Read article
-
Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
-
Synthesis and Characterization of Pyrazole Heterocyclic Derivatives via Vilsmeier-Haack-Reaction and its Schiff`s Bases.
Abstract: The synthesis of New Schiff bases (2; and 3a-c) is reported in this study. These bases were created by reacting -chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (1) with various amines that contained various pharmacophore atoms or groups, such as derivatives of benzothiazole and aniline, in the hopes of having antimicrobial and antifungal properties. Using mild reaction conditions and a good yield percentage, mono-pyrazole Schiff bases (2 and 3a–c) were designed and synthesized by reacting 5-chloro--3-methyl-1-phenyl-pyrazole-4-carbaldehyde …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 34–48 Read article
-
Plant-Derived Vaccines: A Sustainable Approach to Disease Control for Global Health
Abstract: Plant-based vaccines present a novel and environmentally responsible approach to vaccination, with significant potential for improving both human and animal health. These vaccines are safer and less expensive than traditional vaccine manufacturing methods because they use genetically modified plants to create antigens that elicit an immune response. Plant-based systems offer a potential remedy for traditional vaccines' high production costs and environmental impact, which are growing problems. Plant-derived vaccines have shown …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 17–20 Read article
-
Pharmacokinetic and Pharmacodynamic Studies of Black Seed Derived Compound
Abstract: Black seed (Nigella sativa) has been celebrated for centuries for its remarkable therapeutic properties. Among its bioactive compounds, thymoquinone (TQ) has gained significant attention in pharmacological research due to its diverse health benefits. This review delves into the pharmacokinetic (PK) and pharmacodynamic (PD) properties of black seed compounds, with a particular emphasis on TQ, the most extensively studied component. The PK of TQ includes the parameters of absorption, distribution, metabolism, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 36–43 Read article
-
Synthesis and Characterization of a Naphthalene-Derived Schiff Base for Fe³⁺ Sensing Applications
Abstract: The development of chemosensors for metal ions has gained significant attention due to their crucial role in industrial, environmental, and biological applications. Metal ion detection is essential for monitoring environmental pollution, industrial processes, and biological systems where metal homeostasis plays a vital role. In this study, we focus on the synthesis, characterization, and application of a novel naphthalene-based Schiff base ligand, derived from the condensation reaction between 1,8-diaminonaphthalene and 3-nitrobenzaldehyde. …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 1–8 Read article
-
Synthesis, spectroscopic, crystal structure, Hirshfeld surface, computational, and biological investigations on Isophorone derivatives: 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one
Abstract: FT-IR, 1H NMR, and 13C NMR spectroscopy were among the spectroscopic methods used to synthesize and analyze 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one, a new isophorone derivative. Single-crystal X-ray diffraction (SCXRD) was used to determine the crystal structure, which showed that the molecule crystallizes in a monoclinic system (space group P121/c1) with packing configurations and intermolecular interactions. To learn more about the non-covalent interactions influencing the crystal packing, Hirshfeld surface analysis was used. In order …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–69 Read article
-
A Comprehensive Review on Coumarin Derivatives
Abstract: Coumarins are naturally occurring compounds found in plants, fungi, and microorganisms with diverse bioactivities. They have antithrombotic, anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, and neuroprotective properties. Extracting coumarins, using methods like maceration and microwave- assisted extraction, is crucial for their applications. However, safety and toxicology are important, especially in pharmaceuticals, cosmetics, and food additives. Consuming moderate amounts of coumarin-rich foods is generally safe, but excessive intake raises concerns about hepatotoxicity and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 72–80 Read article
-
An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
-
In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
-
Enhancement of Gas Sensitivity of Composites of Carbon Derived from Rubber Tree and SnO2 to Detect Ethanol Vapor at Room Temperature
Abstract: Films of composites of activated carbon powder prepared from saw dust derived from core of rubber tree (Hevea Brasiliensis) and tin oxide (SnO2) were fabricated using the doctor blade method. Carbon powder was activated using phosphoric acid at 500°C for 45 minutes. The weight ratio carbon/SnO2 varied from 0 to 12% in steps of 2. The structural, optical and morphological properties of films were investigated using XRD patterns, UV-visible spectrums …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 2, 2025 · pp. 31–44 Read article
-
Construction of Chalcone–Thiadiazole Derivatives with (Spectral and Anticancer)-Study
Abstract: Most organic chemistry compounds are widely used in the manufacture of medicines and antibiotics. Due to the spread of many epidemics that develop later as a result of not using appropriate antibiotics, these infections may develop in some tissues into carcinogenic tissues. Therefore, many researchers have developed a series of pharmaceutical compounds and developed the method of their connection with cyclic compounds. A series of chalcone derivatives has been presented …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 64–80 Read article
-
Graphene-Derived Reinforced Polymer Composites for Self-Healing and Durability Enhancement in Concrete Structures
Abstract: This study presents a matrix-centric polymer-composite repair binder: an epoxy–polyamide network reinforced with graphene derivatives (GO/rGO, 0.1–1.0 wt%). The polymer drives function via segmental mobility that closes microcracks, while 2D-filler topology densifies the interphase, improves load transfer, and enforces tortuous moisture pathways. Adhesion was high: pull-off (ASTM D4541) reached 13.5 MPa at 2.0 mm displacement; slant-shear (ASTM C882) reached 12.1 MPa at 2.8 mm, with greater deformation capacity (zero stress …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 77–91 Read article
-
Bio-Derived TPS–Lignin Hybrid Composites Reinforced with Modified Coir and Plantain Fibers for Eco-Efficient Structural Applications
Abstract: This study develops bio-derived polymer composites using a thermoplastic starch–lignin (TPS–lignin) matrix reinforced with alkali-treated coir and plantain fibers for sustainable load-bearing applications. The TPS–lignin matrix was formulated using cassava starch, glycerol, and 10 wt% lignin, while coir and plantain fibers were surface-modified using 5 wt% NaOH to enhance interfacial compatibility. Composite laminates were fabricated with varying fiber loadings (10–40 wt%) through melt-mixing and hot-press compression. Tensile, thermal, morphological, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 136–145 Read article