Search
675 articles for “Novel”
-
Design, Synthesis, and Evaluation of Novel Quinazoline Derivatives as Anti-Inflammatory Agents
Abstract: Novel quinazoline derivatives are well-known heterocyclic scaffolds that are renowned for having a wide range of biological functions. A new quinazoline derivative was synthesized from anthranilic acid through a multi-step sequence involving amide formation, cyclization, and aromatic group substitution. The structure of the methoxy- and chloro-substituted final compound was confirmed by IR and 1H NMR spectroscopy. Evaluation of synthesized molecules anti-inflammatory activity using paw edema caused by carrageenan paradigm in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 01–09 Read article
-
Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
-
Development and Analysis of Novel Silver Ion-Conducting Glass-Polymer Electrolytes
Abstract: The development of efficient and stable solid electrolytes is crucial for advancing energy storage technologies such as solid-state batteries and electrochemical devices. In this study, a novel series of silver ion-conducting glass–polymer electrolytes (GPEs) based on the composition (1–x) PEO: x[0.75AgI:0.25(Ag₂O:WO₃)] with x ranging up to 50 wt.% was synthesized and thoroughly analyzed. Unlike conventional techniques such as solution casting or sol–gel methods, these GPEs were fabricated using an innovative …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 600–605 Read article
-
Development of a Novel Analytical Framework for Investigating Non-Symmetric Deformation Behavior in Strip Rolling
Abstract: In recent years, the asymmetrical rolling process has attracted considerable research attention due to its ability to induce non-uniform deformation characteristics within metallic workpieces. In this context, the present study introduces a novel analytical framework for asymmetrical cold rolling based on an enhanced slab method, specifically designed to overcome the inherent limitations of existing analytical models when applied to a wide range of asymmetric rolling conditions. A newly developed mathematical …
Published in Journal of Experimental & Applied Mechanics · Vol. 17, Issue 1, 2026 · pp. 1–21 Read article
-
Modulating Immune System of Mosquitoes with A Novel Salicylate Derivative: A Bioinformatics-Based Study
Abstract: The present study aims to compare the interactions of a novel derivative of salicylic acid, 5-(2-nitroethynl) salicylic acid (5-SANA, salicylic acid nitroalkene), and salicylic acid with the critical residues of mosquito’s juvenile hormone binding protein (mJHBP). Given the better water solubility of 5-SANA and salicylic acid, it is believed that they can interact quicker than the natural substrate, juvenile hormone (JH), with the cavity of mJHBP, a circulating protein in …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
-
Synthesizing Policy Gaps, Sector-Specific Challenges, and Emerging Opportunities to Develop Novel Research Themes in India’s Circular Economy
Abstract: The concept of the Circular Economy represents an important shift away from the linear & take-make-dispose" model toward a regenerative system, with quite a number of aspects in which circularity is needed in India, due to recent decades of rapid industrialization and rising consumption. Despite supportive policy initiatives such as the National Resource Efficiency Policy and Extended Producer Responsibility frameworks, India's transition to CE remains fragmented. This synthesis aims to …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 1, 2026 · pp. 32–39 Read article
-
Wear and Tribological Characteristics of Novel Metal Matrix Composites
Abstract: The development of advanced metal matrix composites (MMCs) with enhanced tribological performance has become increasingly important due to the premature failure of critical engineering components operating under severe wear conditions in automotive, aerospace, marine, defense, and power generation systems. Conventional composites such as Copper–Alumina and Aluminium–Silicon Carbide have demonstrated improved mechanical and wear characteristics; however, their widespread application is often limited by issues including particle agglomeration, non-uniform reinforcement distribution, porosity …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1326–1346 Read article
-
Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
Modeling the Novel Coronavirus Disease (COVID-19) as Hidden Markov Chains
Abstract: The Hidden Markov Model has over the years been an appropriate method for modeling diseases such as HIV AIDS, heart failure, and so on. With the ongoing pandemic affecting Nigeria by being responsible for 2,745 death cases out of 207,616 confirmed cases as of October 10, 2021, the need to study an important parameter of COVID-19, the case fatality rate by building a model and estimating the case fatality rate …
Published in Research & Reviews : Journal of Statistics Read article
-
Revolutionizing Form and Function: Exploring 4D Printing as a Novel Manufacturing Approach for Complex Generative Structures and Customized Formworks
Abstract: This research delves into the transformative potential of 4D printing manufacturing technology, focusing on its innovative application in fabricating intricate generative and computational structures for adaptable formwork in both individualized and mass-customized scenarios. Spanning the interdisciplinary realms of digital design, digital fabrication, and material science, the study comprehensively explores the integration of these diverse fields. Utilizing generative algorithms and parametric design tools, the research employs simulations to realize complex patterns …
Published in International Journal of Manufacturing and Production Engineering · Vol. 1, Issue 2, 2023 · pp. 41–50 Read article
-
A novel similarity measure for interval value picture fuzzy Environment and extended TOPSIS
Abstract: Correct decision-making is the most arduous task in our daily life. The decisions are hard to make in the multi-criteria decision-making (MCDM) problems due to ambiguous and unexpected information. In order to cope with such uncertainties in the data, a new decision-making approach has been developed using a newly defined similarity measure under the framework of interval-valued picture fuzzy set (IVPFS), as an extension of picture fuzzy sets (PFS). In …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 11, Issue 1, 2024 · pp. 1–10 Read article
-
Parametric optimization and validation of novel 3D scanning approach for sustainable manufacturing of patient-specific orthodontic retainers
Abstract: The purpose of the proposed study is to identify the ideal procedure parameters for 3D scanning a denture in order to produce customised orthodontic retainers that can be produced sustainably. However, pilot investigations rarely explore parameters like scanning angle, light intensity, or scanning distance. In order to lower acquisition error, the suggested study examines a method for forecasting the ideal values of the previously indicated scanning parameters. Based on the …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 265–278 Read article
-
Evaluation of Antenna Performance using a Novel Measurement Device: Methodology and Results
Abstract: In the last decade, the field of On Chip Antennas (OCA) has experienced unprecedented growth due to the introduction of small, low-cost, low-power System-on-Chip (SoC) wireless communication devices. OCAs are superior to conventional off-chip antennas in a number of ways. They first reduce the overall size of the wireless communication system since the presence of an OCA eliminates the need for an impedance matching network between the antenna and RF …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 1, 2024 · pp. 24–29 Read article
-
A Novel Approach for Power Generation from Ocean Waves Using Ratchet and Pawl Mechanism
Abstract: Renewable energy sources collectively contribute around 29% to 30% of global electricity generation. Solar and wind power’s intermittency and weather dependency pose challenges for unreliable energy generation, requiring storage solutions like batteries and environmental considerations. By considering the above-mentioned factors, ocean wave energy stands out as a promising and consistent renewable source. Ocean wave energy is highly predictable and consistent, offering a dependable power supply with minimal greenhouse gas emissions …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 1, 2024 · pp. 1–7 Read article
-
An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
-
Improving Polymer Composite Properties Through Reinforcement Learning Guided Prototyping A Novel Approach for Material Engineering
Abstract: Innovative approaches integrating reinforcement learning (RL) and machine learning (ML) into the fields of polymer composite prototyping and soft actuator manufacturing for applications. This new an algorithm utilizing RL optimizes polymer composite fabrication parameters to enhance material properties efficiently. By iteratively adjusting parameters based on predefined objectives, the RL agent guides the prototyping process, promising to revolutionize polymer composite engineering. A finest control method for locked loop control of Shape …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 208–218 Read article
-
A Novel Categorization System for Pressure Ulcers Reframed in the Context of Bioinformatics
Abstract: Pressure sores are a serious complication of multi morbidity and lack of mobility. Pressure injuries are commonly encountered in geriatric patients. Certain well-recognized risk factors, such as immobility and incontinence, may predispose to the development of pressure injury (PI); consequently, risk factor modification is an important aspect of prevention and treatment. One of the fundamental documentation details when describing a wound is the use of the appropriate staging system. Each …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 1–5 Read article
-
Novel Laplace-domain Approach to the Electromagnetic Transients in Compensated High Voltage Power Lines
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. Applying the relations …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 15–21 Read article
-
Novel Nanotherapeutics for the Management of Diabetes
Abstract: Diabetes is a severe chronic disorder with hyperglycemia, either due to dysfunctional pancreas(Type I) or due to malfunctioned glucose utilizing entities like: liver, straight muscle or adipocytes (Type II). Type 1 or Insulin-dependent/Juvenile diabetes and Type 2 Diabetes Mellitus or Non-Insulin dependent/Adult-onset diabetes are the two broad classifications of diabetes. In case of type 1 diabetes injectable insulin is the major form of medication given and in case of Type …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 1, 2024 · pp. 46–67 Read article
-
Internet of Robotic Things in Battlefield Applications: A Novel Study
Abstract: A new era in military operations is promised by the integration of the Internet of Robotic Things into combat applications, which will provide creative solutions that improve situational awareness, efficiency, and safety. To ensure that the use of these technologies is both responsible and efficient, the potential advantages must be weighed against technological difficulties and ethical issues. It will be crucial going forward for military organisations to continue being proactive …
Published in Journal of Nuclear Engineering & Technology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article