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276 articles for “Biological treatment”
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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Formulation And Evaluation Of Captopril Sustained Release Tablet By Qbd Approach.
Abstract: The purpose of present study was to formulation and evaluation of Captopril sustained release tablet by QbD approach using size expanding polymer and cross linker. Captopril is a ACE inhibitor use in treatment of mild to moderate hypertension. Captopril having biological half-life of 2 hrs. The drugs gets degrade as its goes to higher pH, so we selected size expanding GRDDS. In formulation development study by using QbD, we found …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 64–73 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Current Tumour Immunotherapy strategies and their molecular basis
Abstract: AbstractStudying cancer and devising techniques to combat the deadly disease has witnessed a paradigm shift, from conventional toxic treatments of radiation and chemotherapy, to a more specific, and biologically significant immunotherapy and molecular targeted therapy. This can be seen in the global immunotherapy market, which is dominated by North America region valued about $45.9 billion in 2017 that is estimated to reach about $115.9 billion by 2025, and is closely …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 1–18 Read article
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Nerve Damage and Its Remedies
Abstract: Fringe Nerve Wounds are one of the most well-known reasons for hand brokenness brought about by upper appendage injury yet current administration has remained sub-standard. This survey means to make sense of the conventional perspective on pathophysiology of nerve fix and furthermore portray why careful administration is as yet lacking in utilizing the new natural research that has recorded the progressions that happen after the nerve injury, which, could cause …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 7–14 Read article
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Importance of Compost Quality Towards Effective Organic Soil Management: A Case Study under FAO-CFC-TBI Project at Maud Tea Estate, Assam, India
Abstract: AbstractIn today’s agriculture, there has been a growing conviction that organic soil amendment is the best option available to restore and enhance soil potential towards restricting the continuous decline of productivity. The present study under FAO-CFC-TBI project at Maud Tea Estate was aimed to evaluate the role of compost quality towards effective soil management. On-farm compost was produced under biodynamic, vermi, indigenous and Novcom composting method using similar raw materials …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 4, Issue 1, 2015 · pp. 16–26 Read article
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The Function of Diuretics in Current Medical Practice and Prospective Advancements
Abstract: Diuretics have a rich history that spans several centuries, and this review aims to highlight their progression and clinical uses. We start by exploring kidney physiology, followed by a description of how diuretics function through symporters in the renal tubules. Different categories of diuretics are outlined, along with details of their specific actions. Next, we investigate the clinical use of diuretics in conditions, such as congestive heart failure and hypertension, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 70–75 Read article
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Water Pollution: Its Impact on the Human Health: Causes and Preventions
Abstract: In India, water pollution is a big issue. This problem has gotten much worse in recent years as India has become more industrialized and urbanized. Water pollution is the contamination of water bodies; it occurs when pollutants are dumped into water bodies, either directly or indirectly, without proper treatment to remove dangerous substances. Any chemical, physical, or biological change in the quality of water that has a deleterious effect on …
Published in Journal of Water Pollution & Purification Research · Vol. 8, Issue 3, 2021 · pp. 37–42 Read article
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A Brief Review on Inflammatory Mediators and Drug Therapy for Rheumatoid Arthritis
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease which is characterized by inflammation of the joints and destruction of cartilage and bone. The disease pathology is complex which involves the infiltration and activation of various populations of immune cells along with the release of destructive inflammatory mediators into the synovium of affected joints. Several inflammatory mediators are involved in just like IL-1, IL-6, IL-8, IL-17, IL-18 and tumour necrosis factor-alfa. Treatment …
Published in Trends in Drug Delivery · Vol. 6, Issue 2, 2019 · pp. 1–4 Read article
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Erythrodermic Psoriasis: A Case Report Highlighting Clinical Features and Management
Abstract: Background: Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis that presents as widespread erythema, scaling, and systemic complications such as fever, dehydration, and electrolyte imbalances. It requires urgent medical attention due to the risk of life-threatening complications, including sepsis and multi-organ failure. The condition can arise de novo or as an exacerbation of pre-existing psoriasis, often triggered by medication withdrawal, infections, or systemic inflammation. Case Presentation: We …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 01–05 Read article
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Progeria Syndrome Unveiled: A Scientific Odyssey into Premature Aging Mechanisms and Therapeutic Frontiers
Abstract: Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare and fatal genetic disorder in childhood, exhibiting features akin to premature aging. Despite normal appearances in infancy, affected children face accelerated aging with distinct facial characteristics, including micrognathia, dental malformations, lower body weight, early hair loss, decreased joint mobility, lipodystrophy, etc. The cause of HGPS is a point mutation that occurs at the exon 11 of the LMNA gene which normally …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 52–68 Read article
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Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology
Abstract: Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 38–46 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Gingival Markers as a Tool for Predicting Orthodontic Treatment: A Systematic Review
Abstract: To assess gingival markers as a tool for predicting orthodontic treatment is the main aim of this study. There is a continuous search for methodologies to asses or diagnose the periodontal associated disease, thereby providing a quicker and scientifically proven treatment plan. Clinical evaluation and radiographic reports were the main means of detection of any pathology or disease involving periodontium and the alveolar bone around it. Over the passage of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 3, 2022 · pp. 41–47 Read article
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Causes and Measures to Control Root Rot Fungus in Mulberry Ecosystem
Abstract: Root rot is a severe plant disease caused by various soil-borne fungi, including Phytophthora sp., Pythium sp., Rhizoctonia sp., Fusarium sp., and Armillaria sp. These pathogens attack plant roots, leading to decay, stunted growth, wilting, yellowing leaves, and plant death. Root rot typically develops in waterlogged soils with poor drainage, as these conditions create an environment favorable for fungal growth. Factors such as warm temperatures, compacted soil, improper watering practices, …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 36–41 Read article
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Bioinformatics and Medicine: Bringing Data to the Bedside
Abstract: From being an empirical and experience-based practice, modern medicine has transformed into a codified and research-based discipline, known as Evidence-Based Medicine (EBM). Though EBM has greatly enhanced the quality of medical practice through population-scale clinical trials, it still has limitations in managing biologically diverse patient populations, especially when dealing with clinical outliers who respond in an unusual way to standard treatments. With the rapid progress in genomics, proteomics, and high-throughput …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 41–46 Read article
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In Silico Assessment of Drug like Properties of Some Thiadiazole and Oxadiazole Derivatives as HDAC Inhibitors
Abstract: Purpose: To investigate in silico the drug-like properties of some thiadiazole and oxadiazole derivatives as HDAC inhibitors. Methods: We used Chemdraw Ultra 11.0 to redraw all chemical structures. Furthermore, some applications, such as Bio-Loom for Windows - version 1.5, Molinspiration Property Calculator, and ACD/I-LAB, were used to forecast the drug-like properties of thiadiazole and oxadiazole derivatives, including relative molecular mass (MW), partition coefficient log P (cLog P), number of hydrogen …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 1–13 Read article
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The Role of Bioinformatics in Nursing: Transforming Healthcare through Data-Driven Insights
Abstract: Bioinformatics, an interdisciplinary field combining biology, computer science, and information technology, is increasingly shaping the nursing profession. It offers powerful tools for improving patient care, advancing clinical research, and enabling personalized healthcare through data-driven decision-making. This article examines the integration of bioinformatics into nursing practice, tracing its historical roots from the Human Genome Project to its current applications in genomic medicine, precision healthcare, and population health. Nurses now play a …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 3, 2024 · pp. 18–21 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Physico-Chemical and Antioxidative Properties of Whey Protein Beverages
Abstract: Whey, the liquid left after milk casein precipitation, was utilized, and its physicochemical properties were assessed. The aim of the research was to analyze the availability of nutrients in whey by preparing a modified whey protein beverage. Natural and artificial whey protein beverages were prepared. We studied the shelf life of these beverages over a period of 0 to 11 days and compared them based on their acidity, viscosity, pH, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 1–6 Read article