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Trends in Drug Delivery

A Brief Review on Inflammatory Mediators and Drug Therapy for Rheumatoid Arthritis

  1. Puja Kumari Rai
  2. Vimukta Sharma
  3. Jayanti Mukharjee
  4. Vipin V Dhote

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which is characterized by inflammation of the joints and destruction of cartilage and bone. The disease pathology is complex which involves the infiltration and activation of various populations of immune cells along with the release of destructive inflammatory mediators into the synovium of affected joints. Several inflammatory mediators are involved in just like IL-1, IL-6, IL-8, IL-17, IL-18 and tumour necrosis factor-alfa. Treatment of Rheumatoid arthritis used to Small molecules and biological modifiers such as DMARDs, Methotrexate, Gold, Corticosteroids, analgesic and TNF-α blockers an IL-1 antagonist. Keywords: Autoimmune, pathology, immune, small molecules, biological modifiers Cite this ArticlePuja Kumari Rai, Vimukta Sharma, Jayanti Mukharjee, Vipin V. Dhote. A Brief Review on Inflammatory Mediators and Drug Therapy for Rheumatoid Arthritis. Trends in Drug Delivery. 2019; 6(2): 1–4p.
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