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64 articles for “ADME prediction”
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Structure–Property Modeling of Cement-Based Multi-Component Composites Using Ensemble Machine Learning and Explainable Feature Attribution
Abstract: Accurate prediction of compressive strength is central to structure–property optimization, quality control, and sustainability-driven design in cement-based composite materials. Cementitious systems represent heterogeneous multi-phase composites composed of reactive binder matrices and dispersed aggregate phases, whose macroscopic mechanical performance emerges from complex nonlinear interactions among constituents and curing-dependent microstructural evolution. This study develops a data-driven structure–property modeling framework to quantify the nonlinear dependence of compressive strength on multi-component composite composition and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 112–131 Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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The Economic Impact of Land Acquisition for Industrial Projects
Abstract: Land acquisition for industrial projects plays a crucial role in promoting economic development, yet it often leads to significant socio-economic challenges. In India, land acquisition is regulated under the Right to Fair Compensation and Transparency in Land Acquisition, Rehabilitation and Resettlement Act, 2013. While this legislation aims to ensure fair compensation, transparency, and proper rehabilitation for affected individuals, its implementation often faces significant hurdles. Prolonged administrative delays, ongoing legal battles, …
Published in International Journal of Land · Vol. 2, Issue 2, 2025 · pp. 17–24 Read article
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AI in Pharmacy Automation: A Review of Innovations in Robotics, Their Ethical Implications, and Impact on Workflow and Workforce
Abstract: The pharmacy profession has witnessed a paradigm shift with the integration of robotics and artificial intelligence (AI) in automation. Traditional practices that relied heavily on manual dispensing, paper documentation, and technician labor are now being augmented or replaced by robotic dispensing systems, sterile compounding machines, and predictive AI algorithms. These innovations enhance safety, improve efficiency, and reduce errors, while also raising complex ethical questions related to workforce displacement, liability, and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 01–07 Read article
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Knowledge and Practices of Postnatal Mothers Regarding Newborn Care in a Selected Hospital in West Bengal
Abstract: The health of newborns is significantly impacted by the extent of knowledge and behaviors exhibited by mothers in the postnatal period. By assessing the level of knowledge and practices it is possible to predict the cause and reduce the rate of neonatal mortality and morbidity. A research investigation aimed at evaluating the understanding and routines of postnatal mothers regarding the care of newborns in a chosen hospital located in West …
Published in International Journal of Midwifery Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 30–37 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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Role of Artificial Intelligence in Transforming Personalized Learning in Education
Abstract: Artificial Intelligence (AI) is revolutionizing personalized education by tailoring learning experiences to meet each student's unique needs. Through advanced algorithms, AI can adapt educational content to align with individual learning speeds, preferences, and styles. Technologies such as adaptive learning systems, smart tutoring tools, and AI-powered assessments offer instant feedback and assist teachers in quickly identifying areas where students may be struggling. Additionally, predictive analytics help anticipate student outcomes, enabling early …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 12, Issue 3, 2025 · pp. 27–32 Read article
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In Silico Molecular Docking Studies of Phytocompounds from Melissa officinalis Against MPXV Poxin Target
Abstract: Objectives: This study aimed to evaluate the inhibitory potential of phytocompounds of Melissa officinalis against the MPXV poxin protein target, a key virulence factor in monkeypox infection. Methods: Molecular docking performed using PyRx, a virtual screening software, was conducted to predict the binding affinities of the compounds to MPXV poxin. Prior to docking, the compounds were subjected to comprehensive analysis, including Lipinski's rule of five, evaluation of physicochemical properties, pharmacological …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 25–38 Read article
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A Real-Time System for Efficient Laundry Resource Allocation in University Dormitories
Abstract: Adequate management of the available resources in communal places like university dorms is important in improving the convenience of the students, and in providing optimal use of these facilities. This paper describes the design and implementation of a real-time system on efficient allocation of resources when it comes to laundry in a university dormitory. The system also seeks to counter the challenges that are prevalent among students such as long …
Published in International Journal of Advanced Control and System Engineering · Vol. 4, Issue 1, 2026 · pp. 1–10 Read article
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Real-Time System Monitoring and Resource Optimization Using Shell Scripts in UNIX/Linux Environments
Abstract: Real-time system monitoring is a fundamental aspect of system administration in UNIX/Linux environments, as it ensures optimal system performance, reliability, and continuous availability of services. In modern computing infrastructures, systems are expected to operate efficiently under varying workloads, and any degradation in performance, such as CPU overload, memory exhaustion, disk bottlenecks, or network congestion, can significantly impact user experience and system stability. Regular observation and prompt action are crucial for …
Published in Journal of Advances in Shell Programming · Vol. 13, Issue 1, 2026 · pp. 08–15 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Remote Monitoring Sensor Systems and Applications in Health Informatics: Fostering Shell Programming
Abstract: The fascination of sensor systems has been promising for health informatics as their direct initiative for real-time information by observing its accuracy that was required at the time for data collection, monitoring and analysis to improve patient well-being and health system administering. By integrating these systems with wearable devices, biomedical sensors, and other IoT-enabled technologies, patients can experience continuous health tracking, early disease detection, and remote patient monitoring. For example, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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The Awareness–Behaviour Paradox: Media Literacy and Social Media Risk Behaviour Among Nigerian Undergraduates
Abstract: Background: The proliferation of internet-capable devices and social media platforms has created an intricate web of risks for Nigerian undergraduates, including cyberbullying, addiction, misinformation, and exposure to indecent content. While media literacy has been widely proposed in Western scholarship as a sustainable intervention for responsible online behaviour, its protective mechanisms remain insufficiently understood in non-Western contexts, particularly with respect to the psychological pathways through which literacy operates. Objectives: This study …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 121–126 Read article
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The Reaction About Anti-Hypertensive Drugs According to Plasma Renin-Aldosterone States
Abstract: With recent studies, hypertension has not only a simple pathophysiology, thus it can classify details more about and establishing drug therapy strategies compatible with it is a very important method to improve the organ predictive of patients. The purpose of this study is to compare the responsibility of some anti-hypertensive drugs in hypertensive patients according to plasma renin-aldosterone levels, which becomes the background factor of hypertension. We investigated 71 hypertensive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 14–23 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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An approach of Computer Vision Methods for Driver’s Drowsiness and Yawn Detection
Abstract: Numerous studies have demonstrated that 4,444 traffic crashes are primarily caused by driver drowsiness. Due to advancements in digital computer systems, tiredness behaviour may now be studied by researchers worldwide. The goal of this project is to increase road safety by preventing accidents caused by sleepy drivers. To view the driver's face, use real-time facial recognition technology. A driver's attentiveness and reaction time may be impacted by weariness, which raises …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 1, 2023 · pp. 21–26 Read article
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Review article on Quality Control in Clinical Trials
Abstract: Quality control (QC) is a critical component in the conduct of clinical trials, ensuring the accuracy, reliability, and credibility of data collected throughout the study. It encompasses a systematic set of procedures designed to monitor trial conduct and data integrity, thus safeguarding the rights, safety, and well-being of participants. This review explores the principles, implementation, and evolving practices of quality control in clinical trials, highlighting its importance across all phases …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article