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Research and Reviews: A Journal of Pharmacology Original Research

The Reaction About Anti-Hypertensive Drugs According to Plasma Renin-Aldosterone States

  1. Il Gwang Choe Pyongyang general hospital (Pyongyang, DPRK), Okryu dong No1 Daedonggang district PyongYang city

Abstract

With recent studies, hypertension has not only a simple pathophysiology, thus it can classify details more about and establishing drug therapy strategies compatible with it is a very important method to improve the organ predictive of patients. The purpose of this study is to compare the responsibility of some anti-hypertensive drugs in hypertensive patients according to plasma renin-aldosterone levels, which becomes the background factor of hypertension. We investigated 71 hypertensive men. We included patients whose official hypertensive is 150/100 mmHg over, but we excluded patients with secondary hypertensions with target organ disorders, with unclear blood pressure measurement because of arrhythmia. We applied DRC (direct renin concentration), PAC (plasma aldosterone concentration) tests for 14 days in all the members. The tests are performed with blood samples that can be obtained at the rest site using with JL12316 measurement instrument. We administrated 5 drug therapy (hypothiazide 25 mg/d, Losartan 50 mg/d, amlodipine 5 mg/d, hypothiazide and Losartan12.5/50 mg, amlodipine and Losartan 5/50 mg) to the hypertensive patients. We set 14 days as the drug therapy duration until drug effect estimation, and administered all drugs between 6 and 8 A.M. After drug therapy, we compared with responsibility of anti-hypertensive drugs according to plasma renin and aldosterone levels. The response to anti-hypertensive drugs in hypertension patients is regulated by plasma aldosterone concentration, and the PAC is higher, the responsibility of anti-hypertensive drugs is lowered.

Keywords

References (12)

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