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668 articles for “development” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Thoracolumbar Spine Surgery: Peri-operative Nursing Care Needs and Quality of Life
Abstract: Aim and Objective: To explore the nursing care needs of the patients after thoracolumbar spine surgery during preoperative, post-operative, home care and to assess the quality of life. Design: An exploratory study. Methods: The study was conducted among 50 patients who had undergone thoracolumbar spine surgery in neurosurgery units of tertiary care hospital from July 2018 to September 2020. The nursing needs were assessed by interviewing participants telephonically using an …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 13–23 Read article
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Strategies for Flood Mitigation
Abstract: The world has always experienced change. Water-too much or too little is the most common cause of migration and a city's downfall. The notable and significant distinction right now is that we are seeing it in real-time for the first time in human history. We contributed to the dangers that were produced, and we contributed to the remedies that will influence the pace and scope of change and disruption. We …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
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Space Optimization for Residence
Abstract: Apartments are getting smaller as urban housing density rises and the population grows. People are being forced to inhabit less space as a result of rising urbanization expenses and housing costs. In order to have quick access to all of the city's amenities, we find ourselves preferring small flats in the city center or as near to it as feasible. Living in a tiny flat has advantages and disadvantages, of …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 1, 2023 · pp. 10–19 Read article
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Usefulness of Video Assisted Education Programme Concerning Awareness on Management of Selected Nutritional Deficiency Disorders Among Mother of Adolescent Girls at Selected Rural Area of Kolar Taluk
Abstract: Background: With an estimated 190 million adolescents, 22% of whom are girls, India has one of the fastest increasing youth populations in the world. Adolescence, as defined by the WHO, is the period between the ages of 10 and 19, which provides a window of opportunity for improving nutritional status and reversing unhealthy eating habits. A growth spurt, or a time when growth is incredibly rapid, is what defines adolescence. …
Published in International Journal of Women's Health Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 1–5 Read article
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Assessing the Effectiveness of Visual Stimulation on Visual Perceptual Ability Among Intellectually Disabled Children
Abstract: Every child, including those with mild mental retardation, has the right to receive an education. As like normal children, mild mentally intellectually disabled children need education that can help their growth and development and to perform their daily life activities. However, learning sources for intellectually disabled children have several obstacles, including recognition of objects. The purpose of this study is to orient the use of basic articles for mild intellectually …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 12–22 Read article
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Card Fraud Detection Using Artificial Neural Network and Multilayer Perception Algorithm
Abstract: Fraud has posed a significant challenge for merchants, especially in the online business sector, over the course of many years. This is primarily due to the advancements in technology that have made credit card transactions a common method of payment. Credit card fraud refers to the unauthorized use of a credit card by an individual for personal purposes, without the owner's consent and with no intention of paying for the …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 1, Issue 1, 2023 · pp. 21–30 Read article
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IoT Based Smart Saline Bottle for Healthcare
Abstract: There is a vast development in the Healthcare sector with the enhancement of Technology. The fundamental principle in caring for hospitalized patients is to ensure that each patient receives high- quality treatment, close monitoring, and appropriate nutrition in a timely manner. Saline is one of the most popular intravenous therapies given to patients in every hospital. Usually in all cases, the patients are normally treated by saline first for dehydration …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 1, 2023 · pp. 7–11 Read article
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A Review of Optimization of Energy Efficiency Though Phase Change Material in Building
Abstract: Energy use in the construction sector is substantial. Thus, it is crucial that new materials be developed with the intention of improving building thermal efficiency. Thus, over the last few decades, the incorporation of Phase Change Materials has increased. (PCMs) into buildings has gained popularity. Such materials, which have the capacity to both absorb and release energy from/in the environment, can lessen temperature variations, enhancing human comfort while also consuming …
Published in International Journal of Urban Design and Development · Vol. 1, Issue 2, 2023 · pp. 05–12 Read article
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Fruit Adulteration Detection Utilizing Machine Learning Methods
Abstract: A device utilizing Internet of Things (IoT) technology was developed for the identification of fruit adulteration through machine learning methods, specifically targeting formalin content assessment. The identification of the fruits based on their extracted traits has been accomplished using a variety of machine-learning techniques. The formalin concentration can be detected as an estimate of the generated voltage of any fruit via an Arduino Uno board 3 and a volatile compound …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 1, 2023 · pp. 32–45 Read article
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Psoriasis: Causes, Symptoms, Treatment, Effect on Quality of Life and Future Therapeutic Prospects: A Detailed Review
Abstract: Objective: This review’s objective is to provide an outline of how psoriasis is caused, what are its symptoms, what are the conventional methods being employed for treatment, and how future prospects can take over the conventional methods. We also aim to put light on how psoriasis is having a huge impact on people’s life quality in various fields of life and how this effect can be measured using instruments or …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 31–49 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Illuminating the Frontier of Drug Discovery: Unleashing the Power of Bioinformatics for Unprecedented Breakthroughs
Abstract: It takes a long time and a lot of effort to discover and develop new drugs, which necessitates extensive study and testing. With the help of computational techniques and data analysis, bioinformatics has grown to be a potent tool for drug discovery in recent years, allowing researchers to find new drugs faster. In this review, we examine the role of bioinformatics in drug discovery, including the use of ligand- and …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 1–10 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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A Security Investigation Survey of Ransomware Detection and Avoidance Strategies for IoT Networks
Abstract: The internet of things (IoT) refers to the interconnection of a large number of distinct physical objects, which in turn makes possible a variety of services and applications. Because the IoT sector is developing at such a rapid rate, ensuring its safety ought to be a high concern. At this time, ransomware attacks constitute the biggest danger to IoT posed by cyberattacks. Ransomware is software that blocks access to or …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 2, 2023 · pp. 14–23 Read article
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Multidirectional Autonomous UV Sanitation Robot
Abstract: In the healthcare environment, the spread of infectious diseases through respiratory particles poses a significant challenge to maintaining clean and safe surroundings. With shortages in surface disinfectants, the traditional manual cleaning methods have been put under scrutiny, as they often prove inadequate and leave residual contamination. Moreover, the constant operation of healthcare facilities, coupled with staff turnover, increases the risk of virus transmission among healthcare workers. To address these concerns, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 1–10 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Design and Simulation of Low-power, High-speed Effective Area Mux Based One-bit Full Adder Using CMOS Technology
Abstract: Our findings reveal a novel kind of circuit capable of performing both XOR and XNOR operations in parallel. Power dissipation and delay are both greatly reduced in the proposed circuits due to their low output capacitance as well as minimal short-circuit power dissipation. We show six new hybrid 1-bit full-adder (FA) circuits that take use of the XOR-XNOR or XOR/XNOR gates' special full-swing function. Each potential circuit layout has both …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 1, 2023 · pp. 25–33 Read article