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153 articles for “metabolite”
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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Rauwolfia Serpentina: A Comprehensive Phytochemical Study of Its Bioactive Metabolites
Abstract: Rauwolfia Serpentina is an important medicinal plant used in Ayurveda, Unani, and folk medicine system of medicine. This plant grew as a bush in company of other plants as an evergreen structure. It is commonly known as ‘Sarpaghanda’. in Ayurvedic and Unani medicine system. It is safe and effective for the treatment of snakebites and various types of disease like malaria, breast cancer, prostate cancer, high blood pressure, insomnia, epilepsy, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 25–50 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered as one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach nowadays emphasises for new drug discovery, the target protein EGFR (5UGB), ER (2QGT), and PI3KA (4OYS) …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 22–36 Read article
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Phytochemical Evaluation in Various Leaf Extracts of Wild Bhendi
Abstract: The vast diversity of natural products have been used for combating human diseases for thousands of years, since they exhibit a wide range of biological properties that can be exploited for medical application. The present study was carried out to analyse the preliminary phytochemical constituents in various solvent extract of wild Bhendi. The results revealed the presence of medicinally active compounds such as alkaloids, tannin, phenol, saponin, flavonoids and glycosides …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 3, 2021 · pp. 23–28 Read article
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Exploring the Bioactive Potential of Himalayan Lichens: Phytochemical and Antimicrobial Profiling of Xanthoparmelia tinctina and Pyxine subcinerea Extracts
Abstract: The symbiotic association that develops between cyanobacteria, algae, and fungi results in the composite organism known as lichens, which has traits similar to those of plants but differs in its separate parent organisms. Lichens can have a variety of morphological characteristics, including foliose structures that resemble flat leaves, crustose structures that resemble flake crystals, fruticose branches that have short, leafless branches, and leprose-powder-like appearances. Due to their therapeutic potential, lichens …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 21–28 Read article
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Preliminary Phytochemical Investigation of the Different Solvents of the Stem of the Anogesssuspendula: A Vulnerable Taxonomic Tree
Abstract: Medicinal plants are very important, and they are very useful kind of the gift of the nature. From the time remote, the plants and their various parts have been used for a variety of purposes. The development of the civilization has been correlated with the development and the utilization of the plants through various means. They are major sources of the medicines. In this research paper, we have worked on …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 1, 2019 · pp. 31–35 Read article
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Analytical Techniques Used In Metabolomic Analysis
Abstract: Comprehensive studies regarding metabolomics provides us ample of information about the structural properties and various other parameters pertaining to the molecule under study. Metabolomics is employed for managing long-term illness such as cancer, diabetes. It’s applications also stretch to treating diseases such as tachycardia along with various cardiovascular diseases. It is used to treat inborn errors of metabolism which are found out in infants. These molecules along with processes of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 3, 2023 · pp. 52–68 Read article
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Pharmacological Review On Enzalutamide
Abstract: A key therapeutic option in the treatment of prostate cancer, especially metastatic castration-resistant prostate cancer (mCRPC), is Enzalutamide, a second-generation anti androgen drug. Enzalutamide, discovered by Charles Sawyer and Michael Jung at the University of California, Los Angeles, was developed and Food and Drug Administration (FDA)-approved in 2012. Its therapeutic significance was further solidified with subsequent extensions in indications to encompass metastatic castration-sensitive prostate cancer and non-metastatic castration-resistant prostate cancer. …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 7–15 Read article
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Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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A Comprehensive Review on Pharmacological Properties of Coumarins
Abstract: Coumarins are a diverse group of secondary metabolites found in a variety of plant species (over 1200 different coumarins have been identified from natural sources, especially plants), as well as in fungi and microorganisms. Coumarin is a simple, widely occurring chemical structure in nature, present in many plants, fungi, and bacteria. In recent years, these natural compounds have attracted growing interest from the scientific community due to their broad spectrum …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 12–17 Read article
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Comprehensive account on role of catechin based polyphenols in nanocomposite formulations
Abstract: Antioxidants play a crucial role in wellness, health maintenance and the prevention of chronic and degenerative disease, in neuroprotection activities and protection against oxidative cellular damage by U.V. radiation. Polyphenols are secondary metabolites of plants usually involved in defense against ultraviolet radiation or aggression by pathogens. Antioxidant properties, free radical-scavenging abilities and antimicrobial properties of these polyphenols make them useful in the field of biomedical applications, used as food additives, …
Published in Journal of Polymer & Composites · Vol. 8, Issue 1, 2020 · pp. 26–31 Read article
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Non-chemical Management of Tea Diseases
Abstract: Tea (Camellia sinensis), one of the most industrial crops, involved in international trade and tariff is a host to wide array of pathogens. The growing pressure on chemical residue free tea is considered as most prioritized research agenda and hence nonchemical methods have immense significance in tea pest management. Use of botanicals and bioagents is perceived to offer a substantial resistance against pests and diseases by creating a plant defense …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 11, Issue 2, 2022 · pp. 1–7 Read article
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Versatile Application of Tannase: A Review
Abstract: Micro - organisms tannase is industrial-important enzymatic enzymes can, through oxidation with secondary metabolites including such tannins, catalyze that production of Gallic acid or glucose. Tannase are commonly used in the production, drink, food processing and brewing and chemical industries. Tannic acid with low-value agroindustrial waste was also commonly used in manufacturing besides tannase production. Tannase also have huge 124-310 KDa variety with molecular weights as well as a great …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 8, Issue 2, 2023 · pp. 13–17 Read article
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Liquid Chromatography Mass Spectrometer (LC/MS) Profile Revealed Flavonoids with Antioxidant Potential in Butanol Fraction of Gymnema Sylvestre Leaf Extract
Abstract: Gymnema sylvestre (Asclepiadaceae) is widely used in the treatment of several diseases associated with oxidative stress. This study aimed to identify Flavonoids with antioxidant potentials in Butanol fraction of Gymnema sylvestre leaf extract. In vitro antioxidant activity was studied using DPPH and Ferric Reducing Antioxidant Power (FRAP). The results revealed higher radical scavenging activity of 86.53±0.86 in DPPH compared to the control Ascorbic acid with 84.71±0.61 and also similarly in …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 9, Issue 1, 2022 · pp. 26–39 Read article
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A Review Study on Phytochemical and Pharmacological Aspects of Berberis asiatica Roxb. ex DC.
Abstract: Berberis asiatica, belongs to family Berberidaceae, is commonly known as Asian barberry or Kilmora. The plant is widely distributed in Himalayas. Research evidences support its use in various traditional medicinal formulas. Properties like antimicrobial, antidiebetic, anticancerous etc. have been reported in this plant. This review aims to highlight a comprehensive account of phytochemical constituents and pharmacological activities along with traditional uses in a view of many recent findings and its …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 2, 2020 · pp. 8–15 Read article
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Mycotoxins in Grains: Toxicological Impact, Detection Strategies, and Public Health Implications
Abstract: Many types of fungi create mycotoxins, which contaminate cereal grains like wheat, maize, rice, and barley. Even at low doses, aflatoxins, ochratoxins, fumonisins, and deoxynivalenol are harmful to humans and animals. This study covers mycotoxin occurrence, detection, toxicological consequences, and public health concerns in grain-based food systems. Advanced analytical methods, like LC–MS, ELISA, and biosensors, are discussed for their sensitivity and routine monitoring applications. Experimental and epidemiological studies analyze chronic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 8–18 Read article
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Screening and Characterisation of Antibacterial Actinomycetes Isolated From Earthworm
Abstract: The actinomycetes are considered to be the most potent source for the production of secondary metabolites, antibiotics and other bioactive compounds. The present study dealt with the isolation of the actinomycetes from the earthworm, Eisenia fetida. The actinomycetes were identified using slide culture technique and various biochemical tests. The isolates (S1 and S2) showed activity against Gram positive and Gram negative bacteria in primary screening by perpendicular streak method. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 1, 2019 · pp. 77–84 Read article