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42 articles for “Targeted therapy”
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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The Burden of Empirical Therapy: Analyzing the Predominance of Broad-Spectrum Antibiotic Usage in Lower Respiratory Tract Infections
Abstract: Lower respiratory tract infections (LRTIs) remain one of the leading causes of morbidity and hospitalization worldwide, particularly among older adults, immunocompromised individuals, and patients with chronic respiratory disorders. These infections include conditions such as community-acquired pneumonia, hospital-acquired pneumonia, bronchitis, and acute infective exacerbations of chronic lung disease, all of which often require rapid clinical intervention. Because microbiological confirmation of the causative pathogen frequently takes 48–72 hours, clinicians generally initiate empirical …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article
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The Effects of HIV/AIDS Worldwide
Abstract: The Human Immunodeficiency Virus (HIV), which targets immune system conductors (CD4 cells), has infected millions throughout the world. HIV lowers the body's defences by infecting certain bodily fluids (blood, sperm, vaginal fluids, and breast milk) through unprotected sex, contaminated needles, or mother-to-child transmission. Early flu-like symptoms may go unrecognised, but if not treated, HIV advances to AIDS, which is characterised by severe immune system impairment. However, advances in antiretroviral therapy …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 26–31 Read article
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Bacteriophages- A New Frontier in Medicine
Abstract: Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering an innovative alternative to traditional antibiotic treatments, especially in the face of rising antibiotic resistance. The resurgence of phage therapy has been driven by the increasing prevalence of multidrug-resistant bacterial strains and the slowdown in the development of new antibiotics. Phages, unlike antibiotics, target specific bacterial strains, reducing the impact on the natural microbiota and potentially offering a …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 31–35 Read article
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In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations
Abstract: Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 16–24 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Thalassemia and its management – A review article
Abstract: Thalassemia is a hemoglobinopathy burdening India making it earn title of Thalassemia capital of world. Studying last decade, the overall prevalence worldwide and incidence rates have declined but prevalence rates were high in east and Southeast Asian countries. Screening for carriers and affected individuals and genetic counselling are promising approaches for reducing soaring cases and reducing the further spread. Thalassemia affects various organs due to iron overload and haemolysis leading …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 60–73 Read article
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A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article
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Advancing Capsule Technology: A Comprehensive Review of Formulation Strategies
Abstract: Capsules are a popular and versatile oral dosage form used in drug delivery, offering benefits such as ease of swallowing, taste masking, and improved stability of active pharmaceutical ingredients (APIs). They can be made from gelatin or non-gelatin materials like Hydroxypropyl Methylcellulose (HPMC), Polyvinyl Alcohol (PVA), and starch, catering to dietary, cultural, and sustainability needs. Capsules can be engineered for controlled, sustained, or targeted release, enhancing bioavailability, particularly for poorly …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 44–56 Read article
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Effectiveness of Spencer Technique of Mobilization on Adhesive Capsulitis: A Single Case Study
Abstract: Background: Frozen shoulder, or adhesive capsulitis, is a condition characterized by pain, restricted motion, and stiffness in the shoulder joint. This occurs due to inflammation and the thickening of the joint capsule. The Spencer technique, is a manual therapy method consisting of seven steps designed to improve shoulder function by enhancing joint mobility, circulation, and lymphatic flow. These movements target shoulder extension, flexion, circumduction, abduction, and adduction, to reduce stiffness …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 14–20 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Plant-Derived Psychotropic Agents Targeting Neurotransmitter Systems: Pharmacognostic Evidence, Mechanisms, and Clinical Relevance
Abstract: Psychiatric health problems are also a large burden on global health and existing psychotropic drugs may be restricted by relative effectiveness, side effects, and inadequate long-term tolerability. Plant- based psychotropic agents have subsequently been the focus of interest in the form of complementary or alternative therapies. This review outlines the pharmacognostic, mechanisms of action and therapeutic importance of plant-based psychotropic agents against central neurotransmitter systems. The traditional medicinal practices give …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 34–42 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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A Review on Diagnosis and Management of Conjunctivitis
Abstract: Conjunctivitis, typically recounted as crimson eye, is a super ocular circumstance affecting men and ladies of all ages. This abstract aims to summarize the findings of a comprehensive study that delves into the pathogenesis, clinical manifestations, and management strategies for conjunctivitis. A multifaceted approach was employed, including a systematic literature review of conjunctivitis-related studies, clinical observations, and interviews with leading ophthalmologists. The various cases were analysed to assess demographic patterns, …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 35–46 Read article
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Nanotechnology-Based Cosmeceuticals for Anti-Aging and Skin Regeneration
Abstract: Nanotechnology has transformed the cosmetic industry of the cosmeceuticals by allowing the production of sophisticated delivery systems that improve the stability, penetration, bioavailability, and therapeutic efficacy of active ingredients in cosmetics. The present review identifies the value of nanotechnology-based cosmeceuticals in anti-aging and skin regeneration, with special focus on the recent developments in nanocarrier technologies and their use in dermatology. Many nanocarriers have exhibited great potentials in enhancing delivery of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 33–45 Read article
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Metals and Minerals in Pharmacy: Current Trends, Biomedical Applications, and Future Innovations
Abstract: Metals and minerals have played important roles in medicine for centuries, ranging from the use of simple mineral powders in traditional therapies to the development of modern metal-based drugs and nanomaterials. In recent years, advancements in material science, nanotechnology and pharmaceutical engineering have expanded the biomedical relevance of inorganic materials far beyond their conventional use as excipients. This review highlights the growing integration of metallic and mineral systems into pharmaceutical …
Published in International Journal of Minerals · Vol. 2, Issue 2, 2025 · pp. 12–24 Read article
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Practical studies in Vero cell and Human amnion cells for viral and stem cell applications
Abstract: Vero cells are one of the most popular mammalian continuous cells in molecular, cellular, and microbiological research. African green monkey kidneys are used to make these.One continuous cell line is the Vero cell line. This cell line is dependent on anchorage. Vero cells can be cultured in suspension because they are anchorage independent. Thought to be non-tumorigenic cells that came from a female Chlorocebus sabaeus Numerous viruses can infect vero …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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Herbal Frontiers: The Role of Alternative Remedies in Combating Typhoid Fevers
Abstract: Typhoid fever, caused by Salmonella typhi, remains a major health challenge, particularly in developing regions where sanitation and healthcare resources are limited. With an estimated global incidence of 17 million cases annually, the disease poses a significant public health burden. The growing resistance to conventional antibiotics, such as fluoroquinolones and third-generation cephalosporins, exacerbates treatment challenges. This has spurred interest in alternative remedies, including herbal and homeopathic treatments.Herbal medicine offers a …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article