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45 articles for “Physico-chemical properties”
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Panoramic review on Sida rhombifolia L.
Abstract: Sida Rhombifolia is also called Bala and is a well-known Ayurvedic herbal preparation used to treat inflammation, pain and neurological disorders. Literature calls Bala as Sida cordifolia, Sida, root powder acute, Sida cordata or Sida Rhombifolia subsp. retusa to achieve clinical efficacy of standardization of ksheerBala thailam Balamulacherna is essential.The objective of the study is to authenticate the pharmacognostic standards of Sida Rhombifolia root powder. Sida Rhombifolia was standardized with …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 20–32 Read article
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Synthesis of Magnetically Recoverable Nickel (II) Complex-Functionalized Fe3O4@ISNA (ISNA= Isonicotinic acid) Nanomaterials: Catalytic Studies on Nitrophenol Reduction and TD- DFT Studies
Abstract: In this study, we aimed to develop a novel, environmentally sustainable, and magnetically separable heterogeneous nanocatalyst, denoted as Fe3O4@ISNA@NiL (where L represents the ligand). The synthesis involved a two-step process, first, isonicotinic acid was chemically grafted onto the surface of iron oxide nanoparticles (Fe3O4) to introduce functional groups capable of further chemical modification. Subsequently, a nickel(II) Schiff base monomeric complex was anchored onto the modified surface, resulting in a nanocatalyst …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 88–96 Read article
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Synthesis of Magnetically Recoverable Nickel (II) Complex-Functionalized Fe 3 O 4 @ISNA (ISNA= Isonicotinic acid) Nanomaterials: Catalytic Studies on Nitrophenol Reduction and TD- DFT Studies
Abstract: In this study, we aimed to develop a novel, environmentally sustainable, and magnetically separable heterogeneous nanocatalyst, denoted as Fe 3 O 4 @ISNA@NiL (where L represents the ligand). The synthesis involved a two-step process, first, isonicotinic acid was chemically grafted onto the surface of iron oxide nanoparticles (Fe 3 O 4 ) to introduce functional groups capable of further chemical modification. Subsequently, a nickel(II) Schiff base monomeric complex was anchored …
Published in Journal of Polymer & Composites Read article
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Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
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The Effects of Physiochemical Parameters and Microbial Counts on Metal Coupons Corrosions in Freshwater Environment at Different Water Depths
Abstract: The effect of water quality on metal coupon corrosion was investigated at the New Calabar River in Choba. The study examined metal corrosion rates at five different depths: 30 cm, 60 cm, 90 cm, 120 cm, and 150 cm in a freshwater environment. Water samples were collected at each depth and analyzed for physicochemical and microbial parameters to understand their impact on metal degradation. Key parameters measured included pH, Electrical …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 2, 2025 · pp. 31–51 Read article
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High-Performance Polymer Composite Membranes for Selective Ion Transport in Advanced Energy Conversion Systems
Abstract: The development of high-performance Polymer Composite Membranes (PCM) with enhanced ion transport is essential for Polymer Electrolyte Membrane Fuel Cells (PEMFC). However, low-humidity conditions and filter agglomeration still limit long-term membrane stability. This research designs a functionalized PCM integrating cross-linked Poly (Vinyl Alcohol)/Poly (Ethylene Glycol) (PVA/PEG) matrix with sulfonic acid functional groups and Titanium Dioxide (TiO₂) nanofillers to improve selective ion transport under low-humidity conditions. Two types of PCM were …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 724–736 Read article
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Eco-Friendly Elixirs: A Critical Review of Biosurfactants for Sustainable Wastewater Solutions
Abstract: Biosurfactants are the amphiphilic substances which are acquired from the remains of the living microorganisms and have attracted a lot of scientific interests because of their applicability in various fields. This review aims at reviewing current research and development on biosurfactants with special emphasis on their application in wastewater and oil. Biosurfactants being less hazardous to the environment are produced by microorganisms and works as a substitute for chemically produced …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 2, 2024 · pp. 14–33 Read article
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Polymeric Ion-Exchange Complexes of Carbomer for Taste Masking and Enhanced Drug Bioavailability: A Physicochemical and In Vivo Study
Abstract: Famotidine (FAM) was recognized as a crystalline powder that varies in color from white to pale yellow and possesses an extremely bitter flavor. This study aimed to conceal the unpleasant flavor of FAM through employing unconventional ion-exchange resins sourced from Carbomer polymer Evaluation (Carbopol 974P). We used FTIR, DSC, and XRD to look at the drug-resin combination in its hard form to learn more about its physical and chemical properties. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 727–740 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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Assessment of Water Quality along River Ethiope, Delta State
Abstract: The environment, economic growth, and human health all depend on the quantity and quality of water supplies. Given this, the significance of water quality monitoring cannot be overstated.This study was aimed at assessing the water quality of River Ethiope. To achieve this, surface water samples were collected from Ethiope River along its banks at the following towns; Umuaja (SWI), Ebedie (SW2), Abraka (SW3), Sapele (SW4) and Ughara (SW5) axis during …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 8–16 Read article
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Exploring Antimalarial Activity of Chalcone Derivatives through QSAR
Abstract: Background: The core structure of chalcones contains a reactive α,β-unsaturated system within the aromatic rings, which plays a key role in mediating various biological effects. These effects include enzyme inhibition, anticancer activity, anti-inflammatory properties, as well as antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial actions.Modifying the structure by introducing substituent groups to the aromatic ring can enhance potency, reduce toxicity, and expand their range of pharmacological actions. Methods: A total of …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 1–6 Read article
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Exploration of Diverse Epoxy-Based Surface Coating Methods for Enhancing Anticorrosion Characteristics
Abstract: Epoxy-based polymers, commonly referred to as polyepoxides, constitute one of the most versatile and widely adopted categories of polymeric materials due to their exceptional structural, mechanical, and chemical characteristics. Their unique macromolecular framework enables strong interfacial bonding, high mechanical stability, and superior resistance to environmental and chemical degradation, positioning them as advanced alternatives to many traditional organic corrosion inhibitors that often fail under prolonged exposure to aggressive conditions When polyepoxides …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 167–177 Read article
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Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Zinc Oxide Nanoparticles from Murayya koenigii: Antibacterial Potential Review
Abstract: Nanoparticles (NPs) display unique characteristics in contrast to conventional physico-chemical synthesis methods, and they are utilized in various life science fields including surface coating, catalysis, food packaging, corrosion prevention, environmental cleanup, electronics, biomedical applications, and antimicrobial purposes. Metal NPs synthesized through green methods, particularly from plant origins, have garnered significant interest because of their inherent traits such as environmental friendliness, quick production, and cost efficiency. Over the past few years, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 54–67 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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Biomedical Applications of Green-Synthesized Cobalt Oxide Nanoparticles
Abstract: The biomedical potential of cobalt oxide nanoparticles (Co3O4 NPs) synthesized via green methods is gaining recognition due to their biocompatibility and multifunctionality. This article reviews the antibacterial and anticancer properties of Co3O4 NPs synthesized using Delonix regia leaf extract. Characterization techniques confirmed their nanoscale size and uniform morphology. The antibacterial assay against Escherichia coli revealed significant activity, attributed to enhanced permeability and interaction with bacterial membranes. These findings highlight the …
Published in Emerging Trends in Chemical Engineering · Vol. 12, Issue 1, 2025 · pp. 20–29 Read article
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Direct Synthetic Routes of MXenes and Their Application in Carbon Fiber Reinforced Plastics (CFRPs) As Supplementary Sizing Layer†
Abstract: Sized carbon fibers with a supplementary sizing layer of MXenes (synthesized via traditional MAX phases), bonded to carbon fibers (CFs) as well as the resin matrix via different kinds of physicochemical (van der Waals force, hydrogen bonding, covalent bonding) interactions enhanced the performance of the resulting carbon fiber reinforced plastic (CFRP) materials. This is because of the strong interface generated due to the appearance of MXene at the interface of …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 07–13 Read article
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Computational Study of Sombor Index on Generalized Abid–Waheed Graphs for Polymer Modeling
Abstract: This study investigates the topological properties of generalized Abid Waheed graphs. Development of theoretical models in chemistry, reducing computational complexity while analysing large molecules or networks Abid Waheed graphs play a significant role. Motivated by these findings, the research was extended to encompass generalized Abid Waheed graphs, characterized by r cycles of order s. A notable similarity between Abid Waheed graphs and Jahangir graphs was observed. The potential applications of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 267–274 Read article