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202 articles for “PD”
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Numerical Solution of Ordinary Differential Equation and Solution of Partial Differential Equation
Abstract: This research paper explores the fundamental role of various mathematical concepts in engineering and scientific fields like aerospace engineering, materials science, software development, and the energy sector. We delve into the applications of solving algebraic and transcendental equations, finite difference interpolation, numerical methods, solutions to ordinary differential equations (ODEs), and numerical solutions to partial differential equations (PDEs). By examining their applications in these diverse fields, we illustrate the critical importance …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 12–20 Read article
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Rotenone effects on the human body with reference to neurological disorder
Abstract: It has been claimed that the well–known neurotoxic pesticide rotenone, which is known to block the mitochondrial complex I, is strongly linked to the pathophysiology and etiology of Parkinson's disease (PD) in humans. There have been numerous analyses in the past and are still being conducted to establish a relationship between the two in order to completely comprehend the level of harm brought on by rotenone. Numerous laboratory studies shown …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 21–27 Read article
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Parkinson’s Disease Detection on Spiral Images Using CNN with Meta-Classifiers
Abstract: In this work, we provide a detailed method for identifying Parkinson’s Disease (PD) by integrating Convolutional Neural Network (CNN) and meta-classifiers. Through the utilization of a varied dataset consisting of handwritten spiral images, our methodology demonstrates commendable accuracy across a range of models. Specifically, our CNN model with meta-classifiers surpasses alternative approaches, achieving an impressive accuracy rate of 95.07%. By utilizing pre-established VGG16 and ResNet50 architectures as bases, the region-based …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 1, 2025 · pp. 55–66 Read article
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Comprehensive Review on Pulsatile Drug Delivery System: Hybrid Approaches
Abstract: Pulsatile drug delivery systems (PDDS) represent a groundbreaking approach in pharmaceutical technology, allowing for controlled, targeted, and programmable drug release that aligns with circadian rhythms or caters to time-sensitive therapeutic requirements. Although traditional pulsatile systems have shown considerable clinical promise, their effectiveness is frequently compromised by physiological variations such as gastrointestinal transit times, changes in pH, and enzymatic activity. To tackle these obstacles, hybrid PDDS have been developed by combining …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 18–31 Read article
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Large Eddy Simulation: An Approach to Simulate Non-Premixed and Partially Premixed Natural Gas Combustor
Abstract: This paper highlights on the large eddy simulation approach for non-premixed and partially premixed combustor. In the case of large eddy simulation, mainly two scalars are taken into consideration that is mixture fraction and the other one is the progress variable mixture fraction, which tracks the mixing of fuel and the oxidizer, and a progress variable which tracks the global extent of reaction of the local mixture. In the case …
Published in Emerging Trends in Chemical Engineering · Vol. 2, Issue 1, 2015 · pp. 35–42 Read article
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Impact of Work Function Variations on Data Stability of FinFET based 6T SRAM Cell
Abstract: The performance of FinFET SRAM cell is severely affected due to metal gate work function variations (WFV) in FinFET device. In order to provide guidelines for SRAM cell optimization, it is essential to examine the data stability due to the contribution of each cell transistor from WFV point of view. In this work, we investigate the effect of VTH variations of each transistor of tri-gated FinFET 6T SRAM cell on …
Published in Journal of VLSI Design Tools and Technology · Vol. 11, Issue 2, 2021 · pp. 1–13 Read article
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Comparative Analysis of CMOS CNFET and Memristor Based Full Adder Circuits and CMOS Memristor Based Multiplexer Circuits
Abstract: Continued developments in microelectronics technology have led to a myriad of new compute-intensive applications at the micro-edge, such as artificial intelligence and signal and image processing. Multiplication is a crucial arithmetic process in such applications. However, large logic complexities typically seen in traditional multipliers generate combinatorial blocks with long chains of cascaded carry addition. As such, energy efficiency has remained a primary design challenge for these applications, when powered by …
Published in Journal of VLSI Design Tools and Technology · Vol. 12, Issue 2, 2022 · pp. 22–33 Read article
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Enhancement of Proton Density Weighted Magnetic Resonance Images using Singular Value Decomposition in Wavelet Domain
Abstract: Image enhancement techniques for low contrast medical images using Singular Value Decomposition (SVD) in Discrete Wavelet Transform domain (SVD-DWT) are proposed in the literature. However, shift sensitivity, poor directionality and a lack of phase information are the primary drawbacks of the discrete wavelet transform. This work introduces a novel method of image enhancement (SVD-SWT) using SVD in Stationary Wavelet Transform (SWT) to improve the contrast of Proton Density weighted Magnetic …
Published in Research & Reviews: A Journal of Embedded System & Applications · Vol. 10, Issue 2, 2022 · pp. 10–21 Read article
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Improvements in Analog Performance of Dual Metal Gate based Silicon-on-Insulator Junctionless Transistor with Pocket Doped Window
Abstract: This paper elucidates the impact of the pocket doped window on the analog performance of dual metal gate based silicon-on-insulator junctionless transistor (DMG SOIJLT). The analog parameters of the proposed SOIJLT are compared with DMG based conventional SOIJLT. The findings of analog performance comparison reveal that transconductance (gm), transconductance generation factor (TGF), output conductance (gd), output resistance (r0), intrinsic gain (AV), and cut-off frequency (fT) have improved for DMG PD-SOIJLT …
Published in Journal of Microelectronics and Solid State Devices Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Exploring the Complexities of Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurological disorder, primarily affecting older adults, marked by both motor and non-motor symptoms. This review explores PD as a multisystem disorder that influences the central, enteric, and autonomic nervous systems, along with the immune system and gastrointestinal tract. Key pathogenic features include the degeneration of dopamine-producing neurons in the substantia nigra and the formation of Lewy bodies containing misfolded α-synuclein proteins. The bradykinesia, tremors, stiffness, …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Synthesis and Structural Characterization of Nanocrystalline CeO2 and Ce0.95Cu0.05O2 Solid Solution Catalysts Properties and its Applications
Abstract: The Main study and the development of CeO2 and Cu doped CeO2 nanocrystals containing transition-metal species are of crucial importance for understanding the preparation and fabrication of CeO2 and Cu doped CeO2 nanoparticles by solution combustion technique to taken glycine as fuel. Here, we have investigated the effect of Cerium dioxide and Cu dopant ions on the structural properties of Ce1-xCuxO2 nanocrystals (NCs) synthesized via co-precipitation technique. XRD results confirmed …
Published in Journal of Catalyst & Catalysis Read article
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Improvements in Analog Performance of Dual Metal Gate based Silicon-on-Insulator Junctionless Transistor with Pocket Doped Window
Abstract: This paper elucidates the impact of pocket doped window on the analog performance of dual metal gate based silicon-on-insulator junctionless transistor (DMG SOIJLT). The analog parameters of proposed SOIJLT is compared with DMG based conventional SOIJLT. The findings of analog performance comparison reveal that transconductance (gm), transconductance generation factor (TGF), output conductance (gd), output resistance (r0), intrinsic gain (AV), and cut-off frequency (fT) have improved for DMG PD-SOIJLT as compared …
Published in Journal of Microelectronics and Solid State Devices · Vol. 8, Issue 1, 2021 · pp. 1–8 Read article
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Comparative Analysis of OOK and M-ary PPM Modulation Technique over Exponentiated Weibull Distribution under Different Turbulence Regime
Abstract: In this paper, the Exponentiated Weibull distribution has been investigated for different turbulence regime considering the aperture averaging at the receiver. The comparative analysis of modulation technique (on-off keying and pulse position modulation) has been presented for different aperture size under weak, moderate, and strong turbulence regime. The closed form of expression of bit error rate (BER) has been numerically derived from the cumulative distribution function (CDF) using the Gauss- …
Published in Trends in Opto-electro & Optical Communication · Vol. 11, Issue 1, 2021 · pp. 7–12 Read article
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A Study on Quality Tools
Abstract: Quality tools are the instruments used to plan and analyze the data. It facilitates finding the source of the issue and enables the delivery of high-quality care. There are seven quality tools that are frequently utilized in the healthcare sector. Quality tools can be used in various stages of the quality management process, including planning, implementation, and evaluation. They can help organizations to identify areas where improvements can be made, …
Published in Journal of Nursing Science & Practice · Vol. 13, Issue 1, 2023 · pp. 65–70 Read article
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Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
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Stem Cell Therapy for Parkinson's Disease: Past, Present and Future
Abstract: Parkinson’s disease (PD) is one of the most common chronic progressive nervous system disorders of aging. Cell degeneration and death of dopamine neurons (DA neurons) in the substantial nigra, is the underlying feature of PD. Genetic studies showed much about the physiological processes associated with this disease. Replacing the cells lost by injury or disease has become a central idea aiming at the development of novel therapy for neurodegenerative diseases. …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 1, 2019 · pp. 1–12 Read article
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An overview on the diagnosis and approaches in pharmacological management of Parkinson’s disease
Abstract: Parkinson’s disease (PD) might be a mutual neurodegenerative disease considered by a movement disorder containing rest tremor, bradykinesia, rigidity, and postural instability, and second-leading reason of dementia and is categorized by an advanced loss of dopaminergic neurons within the neural structure alongside the occurrence of intraneuronal α-synuclein-positive enclosures. PD is identified where bradykinesia happens along with rigidity or tremor within the existence of supporting features. The diagnosis is clinical, and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 1, 2021 · pp. 1–8 Read article
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An Evaluation of Photodynamic Therapy in Dentistry with a Focus on Surgical Applications
Abstract: Throughout the centuries, various forms of light therapy have found applications in medical settings. These include phototherapy for neonatal jaundice, psoralen molecules combined with ultraviolet A light (PUVA) in dermatology, and techniques like photodynamic therapy (PDT) and photodetection. In recent years, the emergence of antibiotic-resistant strains, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, has necessitated the exploration of alternative treatment options. Photodynamic antimicrobial chemotherapy (PACT) has arisen as …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 1–9 Read article