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295 articles for “Lead optimization”
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Factors Affecting Shear Stress on Tablet Hardness and Disintegration
Abstract: The quality and effectiveness of pharmaceutical tablets depend heavily on several factors influencing shear stress on tablet hardness and disintegration. These factors include formulation composition, wherein the selection and concentration of excipients and active ingredients affect how the tablet material responds to shear stress. Additionally, the compression force, speed, and duration during tablet compression are critical, impacting tablet hardness and disintegration properties. Tablet geometry and design, along with tablet press …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 1–19 Read article
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Revolutionizing Anti-Allergy Medications: A Comprehensive Review of Target Discovery and Medicinal Chemistry
Abstract: Above the past few decades, the prevalence of allergy illnesses has been steadily rising, impacting 20–30% of the world's population. Multiple targets are involved in allergic reactions to infections of the skin, digestive tract, and respiratory system. Developing medications with a good curative efficacy and minimal side effects while utilizing novel multi-targets and processes in accordance with the clinical features of various allergic populations and allergens is the primary challenge …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 49–54 Read article
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Evolution of Lean Manufacturing in Mechanical Industries: From Traditional Tools to Digital Transformation
Abstract: Lean manufacturing has long been a foundational strategy for enhancing productivity, reducing operational waste, and improving overall efficiency in mechanical industries. Initially developed as part of the Toyota Production System, lean principles focused on eliminating non-value-adding activities and streamlining processes using a set of well-established tools such as 5S, Kaizen, Kanban, and value-stream mapping. Over the decades, these principles have been adopted and refined globally, particularly within the mechanical sector, …
Published in Journal of Production Research & Management · Vol. 15, Issue 2, 2025 · pp. 13–18 Read article
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Malicious Network Traffic Detection Using Hybrid Feature Selection with Ensemble Neural Network
Abstract: The detection of malicious network traffic is a critical aspect of cybersecurity, aiming to protect sensitive data and maintain the integrity of network systems. This study introduces a novel approach that combines hybrid feature selection with ensemble neural networks to enhance the accuracy and efficiency of malicious network traffic detection. The dataset used in this study was obtained from Kaggle and offers a wide-ranging and varied collection of network traffic …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 3, 2025 Read article
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Numerical Investigation of AA5053 Through Equal Channel Angular Pressing Technique: An Overview
Abstract: Equal channel angular pressing is recognized as the predominant method for bulk severe plastic deformation processing and has been employed for refining the grain structure in numerous metals and alloys. This study utilized finite element analysis to examine the processing of metallic billets through simple shear deformation. For the study, the die channel angle was chosen based on achieving the minimum energy consumption to induce maximum uniform strain. Among the …
Published in Trends in Machine design · Vol. 12, Issue 3, 2025 · pp. 40–47 Read article
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AI-Assisted Optimization of Supersonic Airfoil Shapes Using CFD Coupling
Abstract: This paper presents a novel framework for optimizing supersonic airfoil geometries through integrated artificial intelligence and computational fluid dynamics coupling. Traditional gradient-based optimization methods for high-speed aerodynamic shapes suffer from computational expense and convergence difficulties in non-convex design spaces. The proposed methodology employs a deep neural network surrogate model trained on high-fidelity Reynolds-Averaged Navier-Stokes solutions to approximate aerodynamic performance metrics across the design space. A hybrid particle swarm-genetic algorithm searches …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 1, 2026 Read article
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Advancements in Humanoid Robot Locomotion: A Review of Control Strategies and Kinematic Models
Abstract: Humanoid robot locomotion has significantly improved over the past few decades, driven by improvements in control strategies and kinematic models. Researchers aim to develop robots that can walk, run, and navigate complex terrains with efficiency and stability. This review explores recent developments in humanoid locomotion, highlighting control strategies such as model predictive control, reinforcement learning, and central pattern generators. Additionally, it examines kinematic models, including inverted pendulum models and zero …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 3, Issue 1, 2025 · pp. 24–30 Read article
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AI-Assisted Gain Scheduling for Real-Time Temperature Control in Chemical Reactors
Abstract: Temperature control in continuous stirred-tank reactors (CSTR) represents a critical challenge in chemical process industries due to inherent nonlinearities, time-varying dynamics, and parametric uncertainties. Conventional proportional-integral-derivative (PID) controllers with fixed gains often fail to maintain optimal performance across varying operating conditions, leading to temperature excursions that compromise product quality and safety. This paper presents a novel AI-assisted gain scheduling framework that integrates artificial neural networks (ANN) with adaptive PID control …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 1, 2026 · pp. 24–33 Read article
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Ultrasonic Dispersion of Halloysite Nanotubes for Enhanced Mechanical, Thermal, and Morphological Performance of Epoxy Composites
Abstract: Halloysite nanotube (HNT)-reinforced epoxy nanocomposites were prepared by mixing HNT with bisphenol-A epoxy (LY 556) using ultrasonication, followed by compression molding. HNT contents of 0–5 wt.% were used. The composites were evaluated for tensile strength, flexural strength, Shore D hardness, Izod impact strength, and thermal stability using thermogravimetric analysis (TGA). The fractured tensile surfaces were also examined to understand the failure mechanism and interaction between HNT and the epoxy matrix. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Evaluation on Bioremediation Kinetics of Petroleum- Contaminated Soils Using Plant-Based Amendments
Abstract: The effectiveness of bioremediation processes is strongly influenced by environmental conditions, reactor design parameters, microbial characteristics, and pollutant properties. This study investigates the combined effects of environmental-related factors, reactor design considerations, organism- related characteristics, and pollutant properties on the degradation of total petroleum hydrocarbons (TPH) in swampy and clay soils amended. Laboratory-scale remediation experiments were conducted over an 84-day period using amendment dosages ranging from 20 to 100 g. The …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 1, 2026 · pp. 24–30 Read article
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Advancements in Heat Exchanger Design for Improved HVAC System Efficiency
Abstract: Due to their direct impact on usage of energy, operational effectiveness, and environmental sustainability, heat exchangers have become vital components of the air conditioning, ventilation, and heating (HVAC) systems. The growing demand for energy-efficient HVAC solutions has driven extensive research and development efforts aimed at improving heat exchanger performance. Traditional designs, such as shell-and-tube and fin-and-tube heat exchangers, have long been utilized in HVAC applications. Nevertheless, these traditional types frequently …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 12, Issue 1, 2025 · pp. 44–52 Read article
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AI Application in the Creation of Medications for COPD
Abstract: The crippling lung condition known as chronic obstructive pulmonary disease (COPD) is typified by a continuous restriction of airflow, which results in increased respiratory dysfunction and a reduced quality of life. The rising incidence of COPD worldwide emphasizes the pressing need for innovative pharmaceutical approaches to address the illness. Even though COPD care has advanced significantly, most current medications concentrate on symptom relief rather than disease change. This gap in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 01–05 Read article
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Smart Trolley System for Retail Stores: A Node MCU-Based Approach for IoT Integration
Abstract: This project report presents the design, development, and implementation of an RFID and IoT-based Smart Trolley System. The project is a collaborative effort undertaken by a group of dedicated individuals. The primary objective is to enhance the traditional shopping experience by leveraging advanced technologies to improve efficiency, convenience, and data analytics in retail environments. The Smart Trolley System integrates Radio-Frequency Identification (RFID) technology and the Internet of Things (IoT) to …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 2, 2024 Read article
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Pharmacovigilance And Drug-Induced Toxicities: A Clinical Perspective
Abstract: Pharmacovigilance, which aims to detect, assess, and prevent medication-induced toxicities and adverse drug reactions (ADRs), is a crucial part of healthcare. This study examines the several kinds of drug-induced toxicities, such as idiosyncratic, dose-dependent, and allergic reactions, and emphasizes the function of clinical pharmacists in the tracking and treatment of these illnesses. Pharmacovigilance systems are crucial because they can identify and handle drug-related safety issues that might not surface during …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 17–30 Read article
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Scheduled Charging and Discharging of Electric Vehicles for Charging Cost Optimization
Abstract: The growing number of Electric Vehicles (EVs) will have remarkable impacts on the power grid as it leads to the increase in total energy consumption. This increases the overall burden on the grid which would require new power plants. However, it is possible to minimize the impact by proper scheduling for charging and discharging of electric vehicles. In this paper, three optimal schemes have been compared i.e. global optimal scheduling …
Published in Journal of Microelectronics and Solid State Devices Read article
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Firefly Algorithm–Based Optimization of Processing Parameters for Enhanced Performance of Polymer Composite Materials
Abstract: Polymer composite materials are extensively used in aerospace, automotive, and oil & gas applications due to their high strength-to-weight ratio and design flexibility. However, achieving optimal mechanical and thermal performance strongly depends on precise control of processing parameters such as curing temperature, energy consumption, and material utilization. Conventional trial-and-error approaches often lead to excessive energy usage, non-uniform curing, and sub-optimal composite properties. To address these challenges, this paper proposes an …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 90–107 Read article
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Ai-Driven Healthcare System for Enhanced Diagnosis and Patient Interaction
Abstract: Deep learning techniques are used in an AI-driven healthcare system to improve disease identification and medical picture analysis. Data collection, preprocessing, model training, and evaluation are all part of the system's systematic workflow. Various deep learning architectures, such as ResNet50, VGG-16, and U-Net, are employed for precise classification and segmentation of medical images. The approach incorporates advanced techniques such as optimization, transfer learning, and data augmentation to significantly enhance the …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 Read article
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Impact of Lubricant Additives on Friction Reduction and Wear Prevention in Machinery
Abstract: Lubrication is essential for ensuring the lifespan and operating efficiency of machinery because it minimizes wear and reduces friction. Modern lubricants are made up of several chemical compounds called lubricant additives, which are essential to boost the lubricant's ability to reduce wear and friction. This study thoroughly examines how lubricant additives affect wear prevention and friction reduction in equipment. This work attempts to break down the principles behind the efficacy …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 2, 2023 · pp. 1–6 Read article
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Phase-Specific Nutrient Requirements in Broilers: Implications for Behavior, Gut Health, Performance, Meat Quality, Welfare, and Economics
Abstract: The broiler industry plays an inevitable role in global food security, requiring optimal formulation strategies tailored to each growth phase, starter, grower, and finisher for sustainable production. This review explores phase-specific nutrient requirements and their implications for broiler performance, meat quality, welfare, and economics. During the starter phase (1–10 days), nutrition focuses on immune development, gut health, and skeletal growth, with high protein and low energy needs. In the grower …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 5–15 Read article
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Performance Evaluation of Eco-friendly Cutting Fluid in Machining Process—An Approach towards Environmentally Friendly Production
Abstract: The machining industry's evolving environmental consciousness has prompted a growing demand for cutting fluids devoid of chlorine and sulphur, thus fostering sustainable machining practices. This surge in demand is driven by mounting apprehensions over environmental contamination and worker safety. As the industry transitions to modern cutting fluids, it becomes imperative to comprehend their effectiveness and the optimal machine parameters required for their deployment in the turning process. In our current …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 149–160 Read article